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Q8XL57 (K6PF2_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphofructokinase 2

EC=2.7.1.11
Alternative name(s):
Phosphofructokinase 2
Phosphohexokinase 2
Gene names
Name:pfkA2
Synonyms:pfk
Ordered Locus Names:CPE1185
OrganismClostridium perfringens (strain 13 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier195102 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termAllosteric enzyme
Complete proteome
Gene Ontology (GO)
   Biological_processfructose 6-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_component6-phosphofructokinase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_function6-phosphofructokinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3663666-phosphofructokinase 2 HAMAP-Rule MF_00339
PRO_0000111945

Regions

Nucleotide binding25 – 295ATP By similarity
Nucleotide binding171 – 1755ATP By similarity
Nucleotide binding188 – 20417ATP By similarity

Sites

Active site1441Proton acceptor By similarity
Binding site1791Substrate By similarity
Binding site2841Substrate By similarity
Binding site2901Substrate By similarity
Binding site2931Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8XL57 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: C5614C41AE638C31

FASTA36639,514
        10         20         30         40         50         60 
MMQPIKKIAI LTGGGDCPGL NAVIRAVTRT AILKYGYEVI GYKFGYRGLY NNDFVKLDLD 

        70         80         90        100        110        120 
SVSGILHRGG TILHSSNKDN LFDYQVEDEN GKIVKKDVSD VGVENLKKEG VDALVVIGGD 

       130        140        150        160        170        180 
GTLTSARDFS RKGVNVIGVP KTIDNDLLAT DVTFGFNTAT EIATEALDRL HTTAESHHRI 

       190        200        210        220        230        240 
MLLEVMGRNA GWIALESGIA GSADVILLPE IPYDINKIVE KVKEREEAGK QFTIIVVAEG 

       250        260        270        280        290        300 
AKPKDGEVVV SKIVDDSPDP IRLGGIANKL AIDLEGLIKN HEIRSTVLGH IQRGGNTSTY 

       310        320        330        340        350        360 
DRILSTKYGV KAVELINSNL FGNMVALKGN KVSYESLENV IGHTKNVDPE GELVNTAKSI 


GISFAD 

« Hide

References

[1]"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater."
Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.
Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13 / Type A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000016 Genomic DNA. Translation: BAB80891.1.
RefSeqNP_562101.1. NC_003366.1.

3D structure databases

ProteinModelPortalQ8XL57.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING195102.CPE1185.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB80891; BAB80891; BAB80891.
GeneID989494.
KEGGcpe:CPE1185.
PATRIC19496320. VBICloPer59675_1257.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0205.
HOGENOMHOG000248869.
KOK00850.
OMAHRIMLLE.
OrthoDBEOG644ZRM.
ProtClustDBCLSK810998.

Enzyme and pathway databases

BioCycCPER195102:GJFM-1230-MONOMER.
UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR012829. PFK.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
TIGRFAMsTIGR02483. PFK_mixed. 1 hit.
PROSITEPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK6PF2_CLOPE
AccessionPrimary (citable) accession number: Q8XL57
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways