Q8XJN2 (ACKA2_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase 2
EC=2.7.2.1

Alternative name(s):
Acetokinase 2

Gene names

Name:	ackA2
Synonyms:	ackB
Ordered Locus Names:	CPE1724

Organism

Clostridium perfringens [Complete proteome] [HAMAP]

Taxonomic identifier

1502 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Acetate kinase 2 HAMAP MF_00020		PRO_0000107547

Sequences

	Sequence		Length	Mass (Da)
	Q8XJN2 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 7A225DE1C9DF4CFD	FASTA	398	43,418
	10 20 30 40 50 60 MNVLVINCGS SSLKYQLIDM DTENALATGL VERIGLEGAN LTQKSEGKDK YEIVEPMKDH 70 80 90 100 110 120 QDAIRLVLGA LIDEKHGVIK SLDEINAIGH RVVHGGEKYA ESALVTEEVM KDLEECAKLA 130 140 150 160 170 180 PLHNPANIIG INACKALMPN VPMVVVFDTA FHQTMPEKAF VYALPYELYE KEHIRKYGFH 190 200 210 220 230 240 GTSHKYVSAK IAEAMGKNIE DLKIITCHLG NGASIAAIKN GKCVDTTMGF TPLEGLVMGT 250 260 270 280 290 300 RCGNIDPAVV TYLIDELGYT SQEVNTLMNK KSGIFGVSGV SSDFRDVEAA ADKGSKEAQI 310 320 330 340 350 360 ALDLFRNSVK KYIGAYIAEM NGCDVIVFTA GVGENSIIER GAICRDLEFL GIELDEERNN 370 380 390 IRAKVAEISK EGSRIKLFVV PTNEELMIAQ DTVSIVSK

References

[1]	"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater." Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H. Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed: 11792842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 13 / Type A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000016 Genomic DNA. Translation: BAB81430.1.
RefSeq	NP_562640.1. NC_003366.1.
3D structure databases
ProteinModelPortal	Q8XJN2.
SMR	Q8XJN2. Positions 1-398.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	990034.
GenomeReviews	Gene locus CPE1724 in contig BA000016_GR.
KEGG	cpe:CPE1724.
NMPDR	fig|195102.1.peg.1787.
PATRIC	19497403. VBICloPer59675_1797.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285863.
OMA	ERNNIRA.
PhylomeDB	Q8XJN2.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	CPER195102:CPE1724-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA2_CLOPE

Accession

Primary (citable) accession number: Q8XJN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program