Reviewed, UniProtKB/Swiss-Prot Q8XJK8 (KGUA_CLOPE)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	CPE1748

Organism

Clostridium perfringens [Complete proteome] [HAMAP]

Taxonomic identifier

1502 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	Guanylate kinase HAMAP MF_00328		PRO_0000170525
Regions
	Domain	11 – 189	179	Guanylate kinase-like
	Nucleotide binding	18 – 25	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8XJK8-1 [UniParc]. Last modified December 12, 2006. Version 3. Checksum: DD7E7AF5E6F7875A	FASTA	216	24,605
	10 20 30 40 50 60 MMNKIHKDNR GVLIVISGPS GAGKGTICKA LLEKHDDIFI SISATTRNPR VGEVDGVNYH 70 80 90 100 110 120 FLTKEEFKQR IAEDDFLEHA EVYGNYYGTP KSSVEKMLDE GKNVILEIDI QGALKVKEKA 130 140 150 160 170 180 TDGVFIFILP PSMEELKQRI IKRGSETPES LMTRFKSAYK EINYVSKYNY AVVNDNVEDA 190 200 210 VKKIEAILLA EKCRVDRLKE NLLESKEDEM HEQLYD

References

[1]

"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater." Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H. Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed: 11792842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 13 / Type A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000016 Genomic DNA. Translation: BAB81454.1. Different initiation.
RefSeq	NP_562664.1.
3D structure databases
HSSP	HSSP built from PDB template 1GKY based on UniProtKB P15454.
ModBase	Search...
Genome annotation databases
GeneID	990058.
GenomeReviews	Gene locus CPE1748 in contig BA000016_GR.
KEGG	cpe:CPE1748.
NMPDR	fig|195102.1.peg.1811.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8XJK8.
Enzyme and pathway databases
BioCyc	CPER195102:CPE1748-MON.
BRENDA	2.7.4.8. 2406.
Family and domain databases
HAMAP	MF_00328. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_CLOPE

Accession

Primary (citable) accession number: Q8XJK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	December 12, 2006
Last modified:	September 22, 2009
This is version 43 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)