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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:CPE1822
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000818 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978401 – 400Exodeoxyribonuclease 7 large subunitAdd BLAST400

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiSKINCIM.
OrthoDBiPOG091H02EK.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XJD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKTLSVGE VNNYVKKLVE NDFILKNLNV KGEISNLKFH SSGHIYFSLK
60 70 80 90 100
DENSKVNCIM FKNNAVNLDF RLEEGMKVEI KARLGVYHKE GTYQLYCENI
110 120 130 140 150
KKAGIGELFE EFHKLKKELS EEGIFDEKYK RALPKFPKRI GIITARTGAA
160 170 180 190 200
VRDIINVIQR RNKSLDIILY PAKVQGENAA DSIIEGIRYF NNEKSVDVII
210 220 230 240 250
LGRGGGSIEE LWAFNNRDLA YEIFNSRIPT VSAVGHEVDF TISDFVSDMR
260 270 280 290 300
APTPSAAGEL VSPSLQEMIN DLLNKKEFLH RAVDRRFLNA KRDVDLLHKG
310 320 330 340 350
LKGNNPTHII EKRIKEVNTL EEKLNFLGKR KIDKAKDELI ALNSILQTLN
360 370 380 390 400
PLNTLGRGYS VIMDKEDKVI NKVSELKKND MVKVIMKDGS VNIDIKIINE
Length:400
Mass (Da):45,492
Last modified:March 1, 2002 - v1
Checksum:i69C93E4BEE1325F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB81528.1.
RefSeqiWP_003481866.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB81528; BAB81528; BAB81528.
KEGGicpe:CPE1822.
PATRICi19497599. VBICloPer59675_1895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB81528.1.
RefSeqiWP_003481866.1. NC_003366.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB81528; BAB81528; BAB81528.
KEGGicpe:CPE1822.
PATRICi19497599. VBICloPer59675_1895.

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiSKINCIM.
OrthoDBiPOG091H02EK.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEX7L_CLOPE
AccessioniPrimary (citable) accession number: Q8XJD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.