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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:CPE1860
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000818 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei52 – 72HelicalUniRule annotationAdd BLAST21
Transmembranei78 – 98HelicalUniRule annotationAdd BLAST21
Transmembranei114 – 134HelicalUniRule annotationAdd BLAST21
Transmembranei145 – 165HelicalUniRule annotationAdd BLAST21
Transmembranei171 – 191HelicalUniRule annotationAdd BLAST21
Transmembranei194 – 214HelicalUniRule annotationAdd BLAST21
Transmembranei223 – 244HelicalUniRule annotationAdd BLAST22
Transmembranei249 – 271HelicalUniRule annotationAdd BLAST23
Transmembranei297 – 317HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088111 – 317Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST317

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XJA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDPKIVMAI VISFIVASIL GPIIIPLLHK LKFGQNIRQE GPKSHLKKAG
60 70 80 90 100
TPTIGGLIFI FATIITMFIM VGNPTDEAMI ALYSFVGFGF VGFLDDLLKI
110 120 130 140 150
IKKKNEGLTS GQKMILLLIV SGFLTWYAYK YIGTSINIPF LNGQINFGLF
160 170 180 190 200
YIPFVMFYFA GVTNAVNLTD GLDGLATSVT VLVTTFLGII SYNLGHISLA
210 220 230 240 250
IFCVALAGAL LAFLRFNAFP ARVFMGDTGS LALGGAVAMV ALILKMPLIL
260 270 280 290 300
VLIGIIYVIE TLSVILQVAS FKLTGKRIFK MAPIHHHFEQ LGWSETKIVS
310
VFSIITVVFC FIAFASL
Length:317
Mass (Da):34,502
Last modified:March 1, 2002 - v1
Checksum:i797A1A82978FD936
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB81566.1.

Genome annotation databases

EnsemblBacteriaiBAB81566; BAB81566; BAB81566.
KEGGicpe:CPE1860.

Similar proteinsi

Entry informationi

Entry nameiMRAY_CLOPE
AccessioniPrimary (citable) accession number: Q8XJA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: June 7, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families