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Q8XIW8

- GLSA2_CLOPE

UniProt

Q8XIW8 - GLSA2_CLOPE

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Protein

Glutaminase 2

Gene
glsA2, CPE1995
Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611Substrate By similarity
Binding sitei113 – 1131Substrate By similarity
Binding sitei158 – 1581Substrate By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei189 – 1891Substrate By similarity
Binding sitei241 – 2411Substrate By similarity
Binding sitei259 – 2591Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCPER195102:GJFM-2049-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase 2 (EC:3.5.1.2)
Gene namesi
Name:glsA2
Ordered Locus Names:CPE1995
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Glutaminase 2UniRule annotationPRO_0000110603Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi195102.CPE1995.

Structurei

3D structure databases

ProteinModelPortaliQ8XIW8.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiMMDVSQI.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XIW8-1 [UniParc]FASTAAdd to Basket

« Hide

MKNFLESLIE NNRQYVEHGK LASYIPELEK ANKEDLGIYI VTLDGKEVGA    50
GEYDKKFTIQ SISKVITLML AILDNGKDRV FSRVGVEPTG DSFNSIVSLE 100
RKPSKKPFNP MVNSGAILTT SLIEGDSEEE KFERILEFTR KVTGNDDIQL 150
NEDVYLSEKE TGDRNRALAY FMKSNGVIEG NIDDILDLYF KQCSLEVNAK 200
DLARFGAMLA NDGVLPWNGE RVISREICRI IKTIMVTCGM YDDSGKFAVH 250
IGIPAKSGVG GGIMAAVPRR MGIGIFGPSL DDKGNSIAGT HVMKDLSEEL 300
DLSIF 305
Length:305
Mass (Da):33,691
Last modified:March 1, 2002 - v1
Checksum:i2951FD6F7A9C8289
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB81701.1.
RefSeqiNP_562911.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB81701; BAB81701; BAB81701.
GeneIDi990310.
KEGGicpe:CPE1995.
PATRICi19497957. VBICloPer59675_2068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB81701.1 .
RefSeqi NP_562911.1. NC_003366.1.

3D structure databases

ProteinModelPortali Q8XIW8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195102.CPE1995.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB81701 ; BAB81701 ; BAB81701 .
GeneIDi 990310.
KEGGi cpe:CPE1995.
PATRICi 19497957. VBICloPer59675_2068.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi MMDVSQI.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci CPER195102:GJFM-2049-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.

Entry informationi

Entry nameiGLSA2_CLOPE
AccessioniPrimary (citable) accession number: Q8XIW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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