Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8XIW8 (GLSA2_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutaminase 2

EC=3.5.1.2
Gene names
Name:glsA2
Ordered Locus Names:CPE1995
OrganismClostridium perfringens (strain 13 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier195102 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00313

Sequence similarities

Belongs to the glutaminase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Glutaminase 2 HAMAP-Rule MF_00313
PRO_0000110603

Sites

Binding site611Substrate By similarity
Binding site1131Substrate By similarity
Binding site1581Substrate By similarity
Binding site1651Substrate By similarity
Binding site1891Substrate By similarity
Binding site2411Substrate By similarity
Binding site2591Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8XIW8 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 2951FD6F7A9C8289

FASTA30533,691
        10         20         30         40         50         60 
MKNFLESLIE NNRQYVEHGK LASYIPELEK ANKEDLGIYI VTLDGKEVGA GEYDKKFTIQ 

        70         80         90        100        110        120 
SISKVITLML AILDNGKDRV FSRVGVEPTG DSFNSIVSLE RKPSKKPFNP MVNSGAILTT 

       130        140        150        160        170        180 
SLIEGDSEEE KFERILEFTR KVTGNDDIQL NEDVYLSEKE TGDRNRALAY FMKSNGVIEG 

       190        200        210        220        230        240 
NIDDILDLYF KQCSLEVNAK DLARFGAMLA NDGVLPWNGE RVISREICRI IKTIMVTCGM 

       250        260        270        280        290        300 
YDDSGKFAVH IGIPAKSGVG GGIMAAVPRR MGIGIFGPSL DDKGNSIAGT HVMKDLSEEL 


DLSIF 

« Hide

References

[1]"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater."
Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.
Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13 / Type A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000016 Genomic DNA. Translation: BAB81701.1.
RefSeqNP_562911.1. NC_003366.1.

3D structure databases

ProteinModelPortalQ8XIW8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING195102.CPE1995.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB81701; BAB81701; BAB81701.
GeneID990310.
KEGGcpe:CPE1995.
PATRIC19497957. VBICloPer59675_2068.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2066.
HOGENOMHOG000216890.
KOK01425.
OMAMMDVSQI.
OrthoDBEOG6N94BK.

Enzyme and pathway databases

BioCycCPER195102:GJFM-2049-MONOMER.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLSA2_CLOPE
AccessionPrimary (citable) accession number: Q8XIW8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families