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Protein

Germination protease

Gene

gpr

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Initiates the rapid degradation of small, acid-soluble proteins during spore germination.UniRule annotation

Catalytic activityi

Endopeptidase action with P4 Glu or Asp, P1 preferably Glu > Asp, P1' hydrophobic and P2' Ala.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiA25.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Germination proteaseUniRule annotation (EC:3.4.24.78UniRule annotation)
Alternative name(s):
GPR endopeptidaseUniRule annotation
Germination proteinaseUniRule annotation
Spore proteaseUniRule annotation
Gene namesi
Name:gprUniRule annotation
Ordered Locus Names:CPE2041
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000818 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000268741 – 7UniRule annotation7
ChainiPRO_00000268758 – 325Germination proteaseAdd BLAST318

Post-translational modificationi

Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.UniRule annotation

Keywords - PTMi

Zymogen

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8XIS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A25 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000058956.
KOiK06012.
OMAiPMGNYIT.
OrthoDBiPOG091H0WE2.

Family and domain databases

Gene3Di3.40.50.1450. 1 hit.
HAMAPiMF_00626. Germination_prot. 1 hit.
InterProiIPR023430. Pept_HybD-like_dom.
IPR005080. Peptidase_A25.
[Graphical view]
PfamiPF03418. Peptidase_A25. 2 hits.
[Graphical view]
PIRSFiPIRSF019549. Peptidase_A25. 1 hit.
ProDomiPD041835. Peptidase_A25. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53163. SSF53163. 1 hit.
TIGRFAMsiTIGR01441. GPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8XIS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNVRTDLAV ESREIYKHRY NREIDGVVFE EKTVEEDIKV TNVDILNEEG
60 70 80 90 100
AKAMEKPIGR YVTIDIPEYT HYDGGIMDEV SHVVAASLEE LINLPEERTA
110 120 130 140 150
LVVGLGNWNV TPDAIGPKVV GKLMVTRHLK KVMPDIIDDS VRPVCAIAPG
160 170 180 190 200
VLGITGIETG EIIKSLVEKI KPDLVVCIDA LASRKLERVA RTIQISNTGI
210 220 230 240 250
SPGAGVGNHR MQINEESLGI PVIALGVPTV VDAATIANDA MDLVLDEMIN
260 270 280 290 300
QADAGKEFYN ILNNIDKNEK GMMIKSLLDP YVGDLMVTPK EIDDIIESVS
310 320
KIIANGINIA LQPNMVLEDI NKFLN
Length:325
Mass (Da):35,634
Last modified:March 1, 2002 - v1
Checksum:iAFE7E17827871ABF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB81747.1.
RefSeqiWP_011010731.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB81747; BAB81747; BAB81747.
KEGGicpe:CPE2041.
PATRICi19498051. VBICloPer59675_2115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB81747.1.
RefSeqiWP_011010731.1. NC_003366.1.

3D structure databases

ProteinModelPortaliQ8XIS3.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA25.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB81747; BAB81747; BAB81747.
KEGGicpe:CPE2041.
PATRICi19498051. VBICloPer59675_2115.

Phylogenomic databases

HOGENOMiHOG000058956.
KOiK06012.
OMAiPMGNYIT.
OrthoDBiPOG091H0WE2.

Family and domain databases

Gene3Di3.40.50.1450. 1 hit.
HAMAPiMF_00626. Germination_prot. 1 hit.
InterProiIPR023430. Pept_HybD-like_dom.
IPR005080. Peptidase_A25.
[Graphical view]
PfamiPF03418. Peptidase_A25. 2 hits.
[Graphical view]
PIRSFiPIRSF019549. Peptidase_A25. 1 hit.
ProDomiPD041835. Peptidase_A25. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53163. SSF53163. 1 hit.
TIGRFAMsiTIGR01441. GPR. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPR_CLOPE
AccessioniPrimary (citable) accession number: Q8XIS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.