Reviewed, UniProtKB/Swiss-Prot Q8XI68 (NTPA_CLOPE)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

CPE2253

Organism

Clostridium perfringens [Complete proteome] [HAMAP]

Taxonomic identifier

1502 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Nucleoside-triphosphatase		PRO_0000178155

Sequences

	Sequence		Length	Mass (Da)
	Q8XI68-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 2032381DE7349397	FASTA	204	22,847
	10 20 30 40 50 60 MKKFILASNN AHKVKEIKEI LKDFNLNILS LNEAGIDIDV EEDGKTFEEN SFKKANEIRK 70 80 90 100 110 120 YLLSKGESDF IVMADDSGLE VDYLNGAPGI YSARYAGEHG NDSKNNEKLL EELKNVKDDE 130 140 150 160 170 180 RKANFICVIV AVTDKGEKIV AEGKSYGLIL EALSGNEGFG YDPLFFVPEY KKTFAEMTSD 190 200 EKNAISHRGR ALEKLKDNLK GILK

References

[1]

"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater." Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H. Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed: 11792842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 13 / Type A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000016 Genomic DNA. Translation: BAB81959.1.
RefSeq	NP_563169.1.
3D structure databases
HSSP	HSSP built from PDB template 1B78 based on UniProtKB Q57679.
ModBase	Search...
Genome annotation databases
GeneID	990606.
GenomeReviews	Gene locus CPE2253 in contig BA000016_GR.
KEGG	cpe:CPE2253.
NMPDR	fig|195102.1.peg.2316.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8XI68.
Enzyme and pathway databases
BioCyc	CPER195102:CPE2253-MON.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_CLOPE

Accession

Primary (citable) accession number: Q8XI68

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	March 1, 2002
Last modified:	July 22, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)