SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8XHZ7

- GLMS_CLOPE

UniProt

Q8XHZ7 - GLMS_CLOPE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, CPE2327
Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei605 – 6051For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciCPER195102:GJFM-2428-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:CPE2327
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 610609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135323Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi195102.CPE2327.

Structurei

3D structure databases

ProteinModelPortaliQ8XHZ7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2
Add
BLAST
Domaini284 – 424141SIS 1
Add
BLAST
Domaini453 – 600148SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiSVFETQT.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8XHZ7-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGYVGQ KKATDILVEG LSKLEYRGYD SAGVAVLEDN KIKAEKHKGR    50
LANLEGMLNE NPIEGGIGIG HTRWATHGEP SDVNSHPHLN NKETIAVVHN 100
GIIENYNELR NWLMEKGYEF KSETDTEVIP NLVDFYYKGD LLDAVMEATK 150
HMEGSYAIGV ICNDEPEKLV AVRKDSPLIV GLGEKEYFIA SDIPAVLNHT 200
REVYLLEDKE FVVLTNDGVT LFDEEKNPVE KEVYHITWNV DAAEKGGYED 250
FMLKEINEQP KAIKDTMTSR IMEEKEVTLD DISITKEYLD NVDRVYIVAC 300
GTAYHAGVIG KYAIEKLVRI PVEVDIASEF RYRDAVITDK TLIIVLSQSG 350
ETADTLAVLR DGQAKGARVL AVTNVVGSSV SREANDVLYT WAGPEIAVAS 400
TKAYVTQLIA MYTLALHFAE LKGSKSVEEI EEIKKAMLEL PEKVEEILKN 450
TDLIKEFAVK ASTEKDLYFL GRGMDYGVAM EGSLKLKEIS YIHSEAYAGG 500
ELKHGPIALI EKDIPVISLL TQRELMDKMI SNVQEVVTRG ANVLGVCFKG 550
DMEESKRKMF EGLIEIPETL SLLSPVLSVV PLQLFSYYVA KAKGFDVDKP 600
RNLAKSVTVE 610
Length:610
Mass (Da):67,804
Last modified:January 23, 2007 - v3
Checksum:i8B57C3D7E79119B2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB82033.1.
RefSeqiNP_563243.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB82033; BAB82033; BAB82033.
GeneIDi990689.
KEGGicpe:CPE2327.
PATRICi19498711. VBICloPer59675_2398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB82033.1 .
RefSeqi NP_563243.1. NC_003366.1.

3D structure databases

ProteinModelPortali Q8XHZ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195102.CPE2327.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB82033 ; BAB82033 ; BAB82033 .
GeneIDi 990689.
KEGGi cpe:CPE2327.
PATRICi 19498711. VBICloPer59675_2398.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi SVFETQT.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci CPER195102:GJFM-2428-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.

Entry informationi

Entry nameiGLMS_CLOPE
AccessioniPrimary (citable) accession number: Q8XHZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi