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Q8XHL4

- FTHS_CLOPE

UniProt

Q8XHL4 - FTHS_CLOPE

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, CPE2469
Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPER195102:GJFM-2582-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:CPE2469
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199340Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195102.CPE2469.

Structurei

3D structure databases

ProteinModelPortaliQ8XHL4.
SMRiQ8XHL4. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8XHL4-1 [UniParc]FASTAAdd to Basket

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MKNDIEIAQS AKMEPIINIA KKIGLGEDDI ELYGKYKCKI SLDAIKKLEN    50
NKDGKLVLVT AINPTPAGEG KSTVTVGLGQ ALNKIGKNTV IALREPSLGP 100
VFGIKGGAAG GGYAQVVPME DINLHFTGDM HAITSANNLL CAAIDNHIHQ 150
GNLLRIDSRR IVFKRVMDMN DRALRNIVVG MGGKINGFLR EDGFMITVAS 200
EIMAILCMAS DLEDLKERMG NILIAYNLDG EPVYAKELEV QGAMALLMKD 250
AIKPNLVQTL ENTPAIIHGG PFANIAHGCN SIIATKTALK MSDITITEAG 300
FGADLGAEKF LDIKCRYGNL NPDCVVLVAT IRALKHHGGV KKDELNISNV 350
DALNKGMKNL EKQIENIKAY GVPVVVAINK FITDSDEEVK AIEDFCKNIG 400
VEVSLTEVWE KGGEGGIDLA NKVIKTMETE PSNFKMIYDS EESIKDKILK 450
IVQTIYGGKG VNYTPQALKQ IAEIEKFNLD KLPICMAKTQ YSLSDNPSLL 500
GRPENFDITV KEVRVSNGAG FIVVLTGDVM TMPGLPKVPA ANRMDIKDNG 550
EIVGLF 556
Length:556
Mass (Da):60,253
Last modified:March 1, 2002 - v1
Checksum:i19AB7A9D7151A7C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB82175.1.
RefSeqiNP_563385.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB82175; BAB82175; BAB82175.
GeneIDi990840.
KEGGicpe:CPE2469.
PATRICi19499013. VBICloPer59675_2538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB82175.1 .
RefSeqi NP_563385.1. NC_003366.1.

3D structure databases

ProteinModelPortali Q8XHL4.
SMRi Q8XHL4. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195102.CPE2469.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB82175 ; BAB82175 ; BAB82175 .
GeneIDi 990840.
KEGGi cpe:CPE2469.
PATRICi 19499013. VBICloPer59675_2538.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CPER195102:GJFM-2582-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.

Entry informationi

Entry nameiFTHS_CLOPE
AccessioniPrimary (citable) accession number: Q8XHL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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