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Q8XHH8 (ADD_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase
EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:add
Ordered Locus Names:CPE2506
OrganismClostridium perfringens [Complete proteome] [HAMAP]
Taxonomic identifier1502 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenosine + H2O = inosine + NH3. HAMAP MF_00540

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenosine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Adenosine deaminase HAMAP MF_00540
PRO_0000194366

Sites

Active site2001Proton donor By similarity
Metal binding121Zinc; catalytic By similarity
Metal binding141Zinc; catalytic By similarity
Metal binding1971Zinc; catalytic By similarity
Metal binding2781Zinc; catalytic By similarity
Binding site141Substrate By similarity
Binding site161Substrate By similarity
Binding site1701Substrate; via amide nitrogen and carbonyl oxygen By similarity
Site2211Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8XHH8 [UniParc].

Last modified March 5, 2002. Version 1.
Checksum: 26A6D7C3DB847076

FASTA33238,015
        10         20         30         40         50         60 
MNLLNLPKIE LHCHLDGSLR VETAIELAKK EGVKLDSYEY DKVKELLVIP KECNSLEDYL 

        70         80         90        100        110        120 
NRFALPVKLL QRAENLERVA FELMEDASKE NVKYIEIRFA PLLHLEKGMT QKEVIESVIK 

       130        140        150        160        170        180 
GIRKAEELYD IKGNLILSCL RHHSIDSVYE VIEEGKNFIG KGVVAIDLAG GELEGFVKPY 

       190        200        210        220        230        240 
EEVMKLARES GFRVTIHAGE TGYGKNVRDA IELLGAERIG HGLFIFNDEE AYNLVKEKGV 

       250        260        270        280        290        300 
TLEMCPKSNI DTKGVNKYED HPIYKYHKDN IRVNLSTDNR TVSNINLTEE FENVHKTFNI 

       310        320        330 
DFEDYKKIYL NSVEASFCSE ELKEKLKLSI II

« Hide

References

[1]"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater."
Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.
Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed: 11792842] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13 / Type A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000016 Genomic DNA. Translation: BAB82212.1.
RefSeqNP_563422.1. NC_003366.1.

3D structure databases

ProteinModelPortalQ8XHH8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID990884.
GenomeReviewsGene locus CPE2506 in contig BA000016_GR.
KEGGcpe:CPE2506.
NMPDRfig|195102.1.peg.2569.
PATRIC19499101. VBICloPer59675_2575.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG630382.
OMACKKYQQQ.
PhylomeDBQ8XHH8.
ProtClustDBPRK09358.

Enzyme and pathway databases

BioCycCPER195102:CPE2506-MONOMER.

Family and domain databases

HAMAPMF_00540. A_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADD_CLOPE
AccessionPrimary (citable) accession number: Q8XHH8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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