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Q8XHA6

- PROB_CLOPE

UniProt

Q8XHA6 - PROB_CLOPE

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Protein
Glutamate 5-kinase
Gene
proB, CPE2579
Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141ATP By similarity
Binding sitei54 – 541Substrate By similarity
Binding sitei141 – 1411Substrate By similarity
Binding sitei157 – 1571Substrate; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi177 – 1782ATP By similarity
Nucleotide bindingi219 – 2257ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPER195102:GJFM-2700-MONOMER.
UniPathwayiUPA00098; UER00359.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinase (EC:2.7.2.11)
Alternative name(s):
Gamma-glutamyl kinase
Short name:
GK
Gene namesi
Name:proB
Ordered Locus Names:CPE2579
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Glutamate 5-kinaseUniRule annotation
PRO_0000109661Add
BLAST

Proteomic databases

PRIDEiQ8XHA6.

Interactioni

Protein-protein interaction databases

STRINGi195102.CPE2579.

Structurei

3D structure databases

ProteinModelPortaliQ8XHA6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0263.
HOGENOMiHOG000246368.
KOiK00931.
OMAiADDFDSR.
OrthoDBiEOG6PGK7G.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8XHA6-1 [UniParc]FASTAAdd to Basket

« Hide

MRKALKDSKR IVVKVGTSTL TYENGSVNLM RIEKLSRVIS DICNMGKEVV    50
LVSSGAIGVG VGKLRLEKKP ETIREKQAVA AVGQCALMHI YNKFFGEYSH 100
VVAQVLLTRD VLENERMKNN VCNTFDTLLE KGIIPIVNEN DAISIDEIQN 150
ILNFGDNDNL SAIVSTLVNA DTLIILSDID GFYDSDPRTN EDSKMLKEVY 200
EITPEIEECA GGAGSNRGTG GMVTKLSAAK VATSNGIDMI LANGENPEIL 250
IDILNGEDIG TMFVAKKGE 269
Length:269
Mass (Da):29,214
Last modified:March 1, 2002 - v1
Checksum:i985BB96992EFB8B4
GO

Sequence cautioni

The sequence CAD12651.1 differs from that shown. Reason: Frameshift at position 19.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ420783 Genomic DNA. Translation: CAD12651.1. Frameshift.
BA000016 Genomic DNA. Translation: BAB82285.1.
RefSeqiNP_563495.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB82285; BAB82285; BAB82285.
GeneIDi990956.
KEGGicpe:CPE2579.
PATRICi19499253. VBICloPer59675_2651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ420783 Genomic DNA. Translation: CAD12651.1 . Frameshift.
BA000016 Genomic DNA. Translation: BAB82285.1 .
RefSeqi NP_563495.1. NC_003366.1.

3D structure databases

ProteinModelPortali Q8XHA6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195102.CPE2579.

Proteomic databases

PRIDEi Q8XHA6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB82285 ; BAB82285 ; BAB82285 .
GeneIDi 990956.
KEGGi cpe:CPE2579.
PATRICi 19499253. VBICloPer59675_2651.

Phylogenomic databases

eggNOGi COG0263.
HOGENOMi HOG000246368.
KOi K00931.
OMAi ADDFDSR.
OrthoDBi EOG6PGK7G.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00359 .
BioCyci CPER195102:GJFM-2700-MONOMER.

Family and domain databases

Gene3Di 3.40.1160.10. 1 hit.
HAMAPi MF_00456. ProB.
InterProi IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000729. GK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SUPFAMi SSF53633. SSF53633. 1 hit.
TIGRFAMsi TIGR01027. proB. 1 hit.
PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the Clostridium perfringens genes involved in the adaptive response to oxidative stress."
    Briolat V., Reysset G.
    J. Bacteriol. 184:2333-2343(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 13 / Type A.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.

Entry informationi

Entry nameiPROB_CLOPE
AccessioniPrimary (citable) accession number: Q8XHA6
Secondary accession number(s): Q8VNV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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