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Protein

Thymidine kinase

Gene

tdk

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotation1
Metal bindingi147ZincUniRule annotation1
Metal bindingi182ZincUniRule annotation1
Metal bindingi185ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi87 – 90ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.1.21 5557

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:STY1301, t1661
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001750131 – 205Thymidine kinaseAdd BLAST205

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi220341.STY1301

Structurei

3D structure databases

ProteinModelPortaliQ8XFQ8
SMRiQ8XFQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
HOGENOMiHOG000076391
KOiK00857
OMAiKEQFGWI

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XFQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLYFYYSA MNAGKSTALL QSSYNYQERG MRTVVYTAEI DDRFGAGKVS
60 70 80 90 100
SRIGLSSPAK LFNQNTSLFE EIRAESARQT IHCVLVDESQ FLTRQQVYQL
110 120 130 140 150
SEVVDKLDIP VLCYGLRTDF RGELFVGSQY LLAWSDKLVE LKTICFCGRK
160 170 180 190 200
ASMVLRLDQD GRPYNEGEQV VIGGNERYVS VCRKHYKDAL EEGSLTAIQE

RHRHI
Length:205
Mass (Da):23,405
Last modified:March 1, 2002 - v1
Checksum:i89F01D1D1D568DE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD08383.1
AE014613 Genomic DNA Translation: AAO69287.1
RefSeqiNP_455750.1, NC_003198.1
WP_000068097.1, NZ_PHKG01000020.1

Genome annotation databases

EnsemblBacteriaiAAO69287; AAO69287; t1661
CAD08383; CAD08383; CAD08383
GeneIDi1247702
KEGGistt:t1661
sty:STY1301
PATRICifig|220341.7.peg.1307

Similar proteinsi

Entry informationi

Entry nameiKITH_SALTI
AccessioniPrimary (citable) accession number: Q8XFQ8
Secondary accession number(s): Q7AN37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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