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Protein

G/U mismatch-specific DNA glycosylase

Gene

mug

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.UniRule annotation

Catalytic activityi

Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase
Biological processDNA damage, DNA excision, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
G/U mismatch-specific DNA glycosylaseUniRule annotation (EC:3.2.2.28UniRule annotation)
Alternative name(s):
Double-strand-specific uracil glycosylaseUniRule annotation
Mismatch-specific uracil DNA-glycosylaseUniRule annotation
Short name:
MUGUniRule annotation
Gene namesi
Name:mugUniRule annotation
Ordered Locus Names:STY3391, t3132
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002386831 – 168G/U mismatch-specific DNA glycosylaseAdd BLAST168

Interactioni

Subunit structurei

Binds DNA as a monomer.UniRule annotation

Protein-protein interaction databases

STRINGi220341.STY3391

Structurei

3D structure databases

ProteinModelPortaliQ8XFG2
SMRiQ8XFG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108VCA Bacteria
COG3663 LUCA
HOGENOMiHOG000264684
KOiK03649
OMAiTGHHFAR

Family and domain databases

CDDicd10028 UDG_F2_MUG, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_01956 MUG, 1 hit
InterProiView protein in InterPro
IPR015637 MUG/TDG
IPR023502 MUG_bact
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR12159 PTHR12159, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XFG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKDILAPGL RVVFCGINPG LSSANTGFPF AHPANRFWKV IHLAGFTDRQ
60 70 80 90 100
LKPEEAEKLL DFRCGVTKLV DRPTVQATEV KLHELRSGGR NLIEKIEDYQ
110 120 130 140 150
PAALAVLGKQ AFEQGFSQRG IAWGKQKIAI GATMVWVLPN PSGLNRIKTE
160
KLVEAYRELD QALIMRGL
Length:168
Mass (Da):18,650
Last modified:March 1, 2002 - v1
Checksum:iA946974A29B16FF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD07737.1
AE014613 Genomic DNA Translation: AAO70675.1
RefSeqiNP_457603.1, NC_003198.1
WP_000237776.1, NZ_PHKG01000004.1

Genome annotation databases

EnsemblBacteriaiAAO70675; AAO70675; t3132
CAD07737; CAD07737; CAD07737
GeneIDi1249654
KEGGistt:t3132
sty:STY3391
PATRICifig|220341.7.peg.3452

Entry informationi

Entry nameiMUG_SALTI
AccessioniPrimary (citable) accession number: Q8XFG2
Secondary accession number(s): Q7AM89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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