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Q8XEC3 (UBIC_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate--pyruvate lyase
Short name=CL
Short name=CPL
EC=4.1.3.40
Gene names
Name:ubiC
Ordered Locus Names:Z5638, ECs5022
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632

Catalytic activity

Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632

Pathway

Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632

Subunit structure

Monomer By similarity. HAMAP MF_01632

Subcellular location

Cytoplasm By similarity HAMAP MF_01632.

Sequence similarities

Belongs to the ubiC family.

Sequence caution

The sequence AAG59238.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB38445.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processUbiquinone biosynthesis
   Cellular componentCytoplasm
   LigandPyruvate
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processubiquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionchorismate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165Chorismate--pyruvate lyase HAMAP MF_01632
PRO_0000240546

Sites

Binding site351Substrate; via amide nitrogen By similarity
Binding site771Substrate By similarity
Binding site1151Substrate; via amide nitrogen By similarity

Experimental info

Sequence conflict1611A → T in BAB38445. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8XEC3 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: A6CA1655BC325479

FASTA16518,791
        10         20         30         40         50         60 
MSHPALTQLR ALRYCKEIPA LEPQLLDWLL LEDSMTKRFE QQGKTVSVTM IREGFVEQNE 

        70         80         90        100        110        120 
IPEELPLLPK ESRYWLREIL LCADGEPWLA GRTVVPVSTL SGPELALQKL GKTPLGRYLF 

       130        140        150        160 
TSSTLTRDFI EIGRDAGLWG RRSRLRLSGK PLLLTELFLP ASPLY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005174 Genomic DNA. Translation: AAG59238.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB38445.1. Different initiation.
PIRB86097.
F91256.
RefSeqNP_290673.2. NC_002655.2.
NP_313049.2. NC_002695.1.

3D structure databases

ProteinModelPortalQ8XEC3.
SMRQ8XEC3. Positions 2-165.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000027962; EBESCP00000026855; EBESCG00000027014.
EBESCT00000055995; EBESCP00000053823; EBESCG00000055043.
GeneID914312.
960084.
GenomeReviewsGene locus Z5638 in contig AE005174_GR.
Gene locus ECs5022 in contig BA000007_GR.
KEGGece:Z5638.
ecs:ECs5022.
PATRIC18359639. VBIEscCol44059_4956.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000011008.
HOGENOMHBG644467.
OMAGRTVIPQ.
ProtClustDBPRK11655.

Enzyme and pathway databases

BioCycECOL83334:ECS5022-MONOMER.

Family and domain databases

HAMAPMF_01632. UbiC.
[Tree]
InterProIPR007440. Chorismate--pyruvate_lyase.
[Graphical view]
KOK03181.
PfamPF04345. Chor_lyase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBIC_ECO57
AccessionPrimary (citable) accession number: Q8XEC3
Secondary accession number(s): Q7A934
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: January 25, 2012
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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