Q8XE96 (ACPH_ECO57) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl carrier protein phosphodiesterase
Short name=ACP phosphodiesterase
EC=3.1.4.14

Gene names

Name:	acpH
Ordered Locus Names:	Z0503, ECs0455

Organism

Escherichia coli O157:H7 [Complete proteome] [HAMAP]

Taxonomic identifier

83334 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP By similarity. HAMAP-Rule MF_01950
Catalytic activity	Holo-[acyl-carrier-protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier-protein]. HAMAP-Rule MF_01950
Sequence similarities	Belongs to the AcpH family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	[acyl-carrier-protein] phosphodiesterase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Acyl carrier protein phosphodiesterase HAMAP-Rule MF_01950		PRO_0000226266

Sequences

	Sequence		Length	Mass (Da)
	Q8XE96 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: F8E6F0CE01D6C395	FASTA	193	22,917
	10 20 30 40 50 60 MNFLAHLHLA HLAESSLSGN LLADFVRGNP EESFPPDVVA GIHMHRRIDV LTDNLPEVRE 70 80 90 100 110 120 AREWFRSETR RVAPITLDVM WDHFLSRHWS QLSPDFPLQE FVCYAREQVM TILPDSPPRF 130 140 150 160 170 180 INLNNYLWSE QWLVRYRDMD FIQNVLNGMA SRRPRLDALR DSWYDLDAHY AALETRFWQF 190 YPRMMAQASR KAL

References

[1]

"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. , Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R. Nature 409:529-533(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.

[2]

"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. , Kuhara S., Shiba T., Hattori M., Shinagawa H. DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005174 Genomic DNA. Translation: AAG54751.1. BA000007 Genomic DNA. Translation: BAB33878.1.
PIR	C85536. G90685.
RefSeq	NP_286143.1. NC_002655.2. NP_308482.1. NC_002695.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	155864.Z0503.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAG54751; AAG54751; Z0503. BAB33878; BAB33878; BAB33878.
GeneID	914557. 957357.
KEGG	ece:Z0503. ecs:ECs0455.
PATRIC	18349867. VBIEscCol44059_0454.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3124.
HOGENOM	HOG000275880.
KO	K08682.
OMA	WLHRQID.
ProtClustDB	PRK10045.
Enzyme and pathway databases
BioCyc	ECOL386585:GJFA-449-MONOMER.
Family and domain databases
HAMAP	MF_01950. AcpH.
InterPro	IPR007431. ACP_phosphodiesterase. IPR023491. ACP_phosphodiesterase_gpbac. [Graphical view]
Pfam	PF04336. DUF479. 1 hit. [Graphical view]
PIRSF	PIRSF011489. DUF479. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACPH_ECO57

Accession

Primary (citable) accession number: Q8XE96
Secondary accession number(s): Q7AH16

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program