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Q8XDZ2 (ARND_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

EC=3.5.1.n3
Gene names
Name:arnD
Ordered Locus Names:Z3514, ECs3144
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides By similarity. HAMAP-Rule MF_01870

Catalytic activity

4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate. HAMAP-Rule MF_01870

Pathway

Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2. HAMAP-Rule MF_01870

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP-Rule MF_01870

Sequence similarities

Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.

Contains 1 NodB homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD HAMAP-Rule MF_01870
PRO_0000383503

Regions

Domain2 – 260259NodB homology

Sequences

Sequence LengthMass (Da)Tools
Q8XDZ2 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: C8DC019C6742938C

FASTA29633,138
        10         20         30         40         50         60 
MTKVGLRIDV DTFRGTREGV PRLLEILSKH NIQASIFFSV GPDNMGRHLW RLVKPQFLWK 

        70         80         90        100        110        120 
MLRSNAASLY GWDILLAGTA WPGKEIGHAN ADIIREAAKY HEVGLHAWDH HAWQARSGNW 

       130        140        150        160        170        180 
DRQTMIDDIA RGLRTLEEII GQPVTCSAAA GWRADQQVIE AKEAFHLRYN SDCRGAMPFR 

       190        200        210        220        230        240 
PLLESGNPGT AQIPVTLPTW DEVIGRDVKA EDFNGWLLNR ILRDKGTPVY TIHAEVEGCA 

       250        260        270        280        290 
YQHNFVDLLK RAAQEGVTFC PLSELLSETL PLGQVVRGNI AGREGWLGCQ QIAGSR 

« Hide

References

[1]"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7."
Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. expand/collapse author list , Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R.
Nature 409:529-533(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
[2]"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. expand/collapse author list , Kuhara S., Shiba T., Hattori M., Shinagawa H.
DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005174 Genomic DNA. Translation: AAG57387.1.
BA000007 Genomic DNA. Translation: BAB36567.1.
PIRG85865.
H91021.
RefSeqNP_288832.1. NC_002655.2.
NP_311171.1. NC_002695.1.

3D structure databases

ProteinModelPortalQ8XDZ2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING155864.Z3514.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG57387; AAG57387; Z3514.
BAB36567; BAB36567; BAB36567.
GeneID916852.
959273.
KEGGece:Z3514.
ecs:ECs3144.
PATRIC18355670. VBIEscCol44059_3036.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0726.
HOGENOMHOG000261199.
KOK13014.
OMALHAWDHF.
OrthoDBEOG6423D0.

Enzyme and pathway databases

BioCycECOL386585:GJFA-3096-MONOMER.
ECOO157:Z3514-MONOMER.
UniPathwayUPA00030.
UPA00036; UER00496.

Family and domain databases

Gene3D3.20.20.370. 2 hits.
HAMAPMF_01870. ArnD.
InterProIPR023557. ArnD.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view]
PfamPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMSSF88713. SSF88713. 2 hits.
PROSITEPS51677. NODB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARND_ECO57
AccessionPrimary (citable) accession number: Q8XDZ2
Secondary accession number(s): Q7AC22
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways