Q8XDF7 (LLDD_ECO57) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: L-lactate dehydrogenase [cytochrome] EC=1.1.2.3 | ||||
| Gene names |
| ||||
| Organism | Escherichia coli O157:H7 [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83334 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 396 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP MF_01559 |
| Cofactor | FMN By similarity. HAMAP MF_01559 |
| Sequence similarities | Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Contains 1 FMN hydroxy acid dehydrogenase domain. |
Ontologies
| Keywords | |
|---|---|
| Ligand | FMN Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | lactate metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | FMN binding Inferred from electronic annotation. Source: InterPro L-lactate dehydrogenase (cytochrome) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 396 | 396 | L-lactate dehydrogenase [cytochrome] HAMAP MF_01559 | PRO_0000206336 | |||||
Regions | |||||||||
| Domain | 1 – 380 | 380 | FMN hydroxy acid dehydrogenase | ||||||
| Nucleotide binding | 306 – 330 | 25 | FMN By similarity | ||||||
Sites | |||||||||
| Active site | 275 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 24 | 1 | Substrate Potential | ||||||
| Binding site | 106 | 1 | FMN By similarity | ||||||
| Binding site | 127 | 1 | FMN By similarity | ||||||
| Binding site | 129 | 1 | Substrate By similarity | ||||||
| Binding site | 155 | 1 | FMN By similarity | ||||||
| Binding site | 164 | 1 | Substrate By similarity | ||||||
| Binding site | 251 | 1 | FMN By similarity | ||||||
| Binding site | 278 | 1 | Substrate Potential | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE005174 Genomic DNA. Translation: AAG58752.1. BA000007 Genomic DNA. Translation: BAB37906.1. |
| PIR | C91189. D86036. |
| RefSeq | NP_290188.1. NC_002655.2. NP_312510.1. NC_002695.1. |
3D structure databases | |
| ProteinModelPortal | Q8XDF7. |
| SMR | Q8XDF7. Positions 3-377. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000028385; EBESCP00000027278; EBESCG00000027436. EBESCT00000057284; EBESCP00000055112; EBESCG00000056332. |
| GeneID | 915575. 960943. |
| GenomeReviews | Gene locus Z5032 in contig AE005174_GR. Gene locus ECs4483 in contig BA000007_GR. |
| KEGG | ece:Z5032. ecs:ECs4483. |
| PATRIC | 18358583. VBIEscCol44059_4457. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000009653. |
| HOGENOM | HBG517781. |
| OMA | IGWLTEN. |
| ProtClustDB | PRK11197. |
Enzyme and pathway databases | |
| BioCyc | ECOL83334:ECS4483-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01559. L-lact_dehydr. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR012133. Alpha-hydoxy_acid_DH_FMN. IPR000262. FMN-dep_DH. IPR008259. FMN_hydac_DH_AS. IPR020920. L-lactate_DHase_cyt. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| KO | K00101. |
| Pfam | PF01070. FMN_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF000138. Al-hdrx_acd_dh. 1 hit. |
| PROSITE | PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LLDD_ECO57 | ||||||||
| Accession | Primary (citable) accession number: Q8XDF7 Secondary accession number(s): Q7A9U9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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