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Q8XDF7

- LLDD_ECO57

UniProt

Q8XDF7 - LLDD_ECO57

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Protein
L-lactate dehydrogenase
Gene
lldD, Z5032, ECs4483
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain By similarity.

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.

Cofactori

FMN By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 241Substrate Reviewed prediction
Binding sitei106 – 1061FMN By similarity
Binding sitei127 – 1271FMN By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei155 – 1551FMN By similarity
Binding sitei164 – 1641Substrate By similarity
Binding sitei251 – 2511FMN By similarity
Active sitei275 – 2751Proton acceptor By similarity
Binding sitei278 – 2781Substrate Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi306 – 33025FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. L-lactate dehydrogenase (cytochrome) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4450-MONOMER.
ECOO157:LLDD-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase (EC:1.1.-.-)
Gene namesi
Name:lldD
Ordered Locus Names:Z5032, ECs4483
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

Subcellular locationi

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396L-lactate dehydrogenase
PRO_0000206336Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5032.

Structurei

3D structure databases

ProteinModelPortaliQ8XDF7.
SMRiQ8XDF7. Positions 3-377.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 380380FMN hydroxy acid dehydrogenase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1304.
HOGENOMiHOG000217464.
KOiK00101.
OMAiDCTLLGR.
OrthoDBiEOG6HMXBG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01559. L_lact_dehydr.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8XDF7-1 [UniParc]FASTAAdd to Basket

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MIISAASDYR AAAQRILPPF LFHYMDGGAY SEYTLRRNVE DLSEVALRQR    50
ILKNMSDLSL ETTLFNEKLS MPVALAPVGL CGMYARRGEV QAAKAADAHG 100
IPFTLSTVSV CPIEEVAPAI KRPMWFQLYV LRDRGFMRNA LERAKAAGCS 150
TLVFTVDMPT PGARYRDAHS GMSGPNAAMR RYLQAVTHPQ WAWDVGLNGR 200
PHDLGNISAY LGKPTGLEDY IGWLGNNFDP SISWKDLEWI RDFWDGPMVI 250
KGILDPEDAR DAVRFGADGI VVSNHGGRQL DGVLSSARAL PAIADAVKGD 300
IAILADSGIR NGLDVVRMIA LGADTVLLGR AFLYALATAG QAGVANLLNL 350
IEKEMKVAMT LTGAKSISEI TQDSLVQGLG KELPTALAPM AKGNAA 396
Length:396
Mass (Da):42,758
Last modified:March 1, 2002 - v1
Checksum:iCA0D8E208613BF83
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58752.1.
BA000007 Genomic DNA. Translation: BAB37906.1.
PIRiC91189.
D86036.
RefSeqiNP_290188.1. NC_002655.2.
NP_312510.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG58752; AAG58752; Z5032.
BAB37906; BAB37906; BAB37906.
GeneIDi915575.
960943.
KEGGiece:Z5032.
ecs:ECs4483.
PATRICi18358583. VBIEscCol44059_4457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58752.1 .
BA000007 Genomic DNA. Translation: BAB37906.1 .
PIRi C91189.
D86036.
RefSeqi NP_290188.1. NC_002655.2.
NP_312510.1. NC_002695.1.

3D structure databases

ProteinModelPortali Q8XDF7.
SMRi Q8XDF7. Positions 3-377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z5032.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG58752 ; AAG58752 ; Z5032 .
BAB37906 ; BAB37906 ; BAB37906 .
GeneIDi 915575.
960943.
KEGGi ece:Z5032.
ecs:ECs4483.
PATRICi 18358583. VBIEscCol44059_4457.

Phylogenomic databases

eggNOGi COG1304.
HOGENOMi HOG000217464.
KOi K00101.
OMAi DCTLLGR.
OrthoDBi EOG6HMXBG.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-4450-MONOMER.
ECOO157:LLDD-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01559. L_lact_dehydr.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiLLDD_ECO57
AccessioniPrimary (citable) accession number: Q8XDF7
Secondary accession number(s): Q7A9U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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