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Q8XD88

- KGUA_ECO57

UniProt

Q8XD88 - KGUA_ECO57

Protein

Guanylate kinase

Gene

gmk

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Essential for recycling GMP and indirectly, cGMP.UniRule annotation

    Catalytic activityi

    ATP + GMP = ADP + GDP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. guanylate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. purine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-4491-MONOMER.
    ECOO157:GMK-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
    Alternative name(s):
    GMP kinaseUniRule annotation
    Gene namesi
    Name:gmkUniRule annotation
    Ordered Locus Names:Z5074, ECs4523
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Guanylate kinasePRO_0000170536Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi155864.Z5074.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8XD88.
    SMRiQ8XD88. Positions 3-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 184181Guanylate kinase-likeUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the guanylate kinase family.UniRule annotation
    Contains 1 guanylate kinase-like domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0194.
    HOGENOMiHOG000037638.
    KOiK00942.
    OMAiMSHYNEY.
    OrthoDBiEOG6CP410.

    Family and domain databases

    Gene3Di3.40.50.300. 3 hits.
    HAMAPiMF_00328. Guanylate_kinase.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00625. Guanylate_kin. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8XD88-1 [UniParc]FASTAAdd to Basket

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    MAQGTLYIVS APSGAGKSSL IQALLKTQPL YDTQVSVSHT TRQPRPGEVH    50
    GEHYFFVNHD EFKEMISRDA FLEHAEVFGN YYGTSREAIE QVLATGVDVF 100
    LDIDWQGAQQ IRQKMPHARS IFILPPSKIE LDRRLRGRDQ DSEEVIAKRM 150
    AQAVAEMSHY AEYDYLIVND DFDTALTDLK TIIRAERLRM SRQKQRHDAL 200
    ISKLLAD 207
    Length:207
    Mass (Da):23,651
    Last modified:March 1, 2002 - v1
    Checksum:iCE669DB404E481E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG58792.1.
    BA000007 Genomic DNA. Translation: BAB37946.1.
    PIRiC91194.
    D86041.
    RefSeqiNP_290228.1. NC_002655.2.
    NP_312550.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG58792; AAG58792; Z5074.
    BAB37946; BAB37946; BAB37946.
    GeneIDi915521.
    960897.
    KEGGiece:Z5074.
    ecs:ECs4523.
    PATRICi18358669. VBIEscCol44059_4500.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG58792.1 .
    BA000007 Genomic DNA. Translation: BAB37946.1 .
    PIRi C91194.
    D86041.
    RefSeqi NP_290228.1. NC_002655.2.
    NP_312550.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali Q8XD88.
    SMRi Q8XD88. Positions 3-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z5074.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG58792 ; AAG58792 ; Z5074 .
    BAB37946 ; BAB37946 ; BAB37946 .
    GeneIDi 915521.
    960897.
    KEGGi ece:Z5074.
    ecs:ECs4523.
    PATRICi 18358669. VBIEscCol44059_4500.

    Phylogenomic databases

    eggNOGi COG0194.
    HOGENOMi HOG000037638.
    KOi K00942.
    OMAi MSHYNEY.
    OrthoDBi EOG6CP410.

    Enzyme and pathway databases

    BioCyci ECOL386585:GJFA-4491-MONOMER.
    ECOO157:GMK-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 3 hits.
    HAMAPi MF_00328. Guanylate_kinase.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00625. Guanylate_kin. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiKGUA_ECO57
    AccessioniPrimary (citable) accession number: Q8XD88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3