Reviewed,
UniProtKB/Swiss-Prot Q8XD24 (COPA_ECO57)
Last modified
June 16, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Copper-exporting P-type ATPase A EC=3.6.3.n1 | ||||
| Gene names |
| ||||
| Organism | Escherichia coli O157:H7 [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83334 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 834 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Involved in copper export By similarity. |
| Catalytic activity | ATP + H2O + Cu1+(In) = ADP + phosphate + Cu1+(Out). |
| Subcellular location | Cell membrane; Multi-pass membrane protein Probable. |
| Sequence similarities | Belongs to the cation transport ATPase (P-type) family. Type IB subfamily. Contains 2 HMA domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Copper transport Ion transport Transport |
| Cellular component | Cell membrane Membrane |
| Domain | Repeat Transmembrane |
| Ligand | ATP-binding Copper Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | ATP biosynthetic process Inferred from electronic annotation. Source: InterPro copper ion transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper ion bindingInferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activityInferred from electronic annotation. Source: InterPro magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 834 | 833 | Copper-exporting P-type ATPase A | PRO_0000046321 | |||||
Regions | |||||||||
| Transmembrane | 187 – 207 | 21 | Potential | ||||||
| Transmembrane | 218 – 238 | 21 | Potential | ||||||
| Transmembrane | 254 – 274 | 21 | Potential | ||||||
| Transmembrane | 284 – 304 | 21 | Potential | ||||||
| Transmembrane | 438 – 458 | 21 | Potential | ||||||
| Transmembrane | 464 – 484 | 21 | Potential | ||||||
| Transmembrane | 779 – 799 | 21 | Potential | ||||||
| Transmembrane | 801 – 821 | 21 | Potential | ||||||
| Domain | 4 – 65 | 62 | HMA 1 | ||||||
| Domain | 100 – 163 | 64 | HMA 2 | ||||||
Sites | |||||||||
| Active site | 523 | 1 | 4-aspartylphosphate intermediate Probable | ||||||
| Metal binding | 14 | 1 | Copper Potential | ||||||
| Metal binding | 17 | 1 | Copper Potential | ||||||
| Metal binding | 110 | 1 | Copper Potential | ||||||
| Metal binding | 113 | 1 | Copper Potential | ||||||
| Metal binding | 720 | 1 | Magnesium By similarity | ||||||
| Metal binding | 724 | 1 | Magnesium By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. Blattner F.R.Nature 409:529-533(2001) [PubMed: 11206551] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC. |
| [2] | "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. Shinagawa H.DNA Res. 8:11-22(2001) [PubMed: 11258796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC. |
Cross-references
Sequence databases | |
|---|---|
| AE005174 Genomic DNA. Translation: AAG54833.1. BA000007 Genomic DNA. Translation: BAB33960.1. | |
| PIR | A90696. E85546. |
| RefSeq | NP_286225.1. NP_308564.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AFJ based on UniProtKB P04129. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 914641. 957460. |
| GenomeReviews | Gene locus Z0604 in contig AE005174_GR. Gene locus ECs0537 in contig BA000007_GR. |
| KEGG | ece:Z0604. ecs:ECs0537. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q8XD24. |
| OMA | Q8XD24. SCVSRVQ. |
Enzyme and pathway databases | |
| BioCyc | ECOL83334:ECS0537-MON. |
Family and domain databases | |
| InterPro | IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR006403. ATPase_P-typ_cat/Cu-transptr. IPR000695. ATPase_P-typ_H-transp. IPR006416. ATPase_P-typ_heavy-metal. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_phosphor_site. IPR005834. Dehalogen-like_hydro. IPR017969. Heavy-metal-associated_CS. IPR006121. HeavyMe_transpt. [Graphical view] |
| PANTHER | PTHR11939. ATPase_P. 1 hit. |
| Pfam | PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 2 hits. PF00702. Hydrolase. 1 hit. [Graphical view] |
| PRINTS | PR00119. CATATPASE. PR00120. HATPASE. |
| TIGRFAMs | TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 2 hits. |
| PROSITE | PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 1 hit. PS50846. HMA_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | COPA_ECO57 | ||||||||
| Accession | Primary (citable) accession number: Q8XD24 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

Clusters with


