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Protein

HTH-type transcriptional regulator CueR

Gene

cueR

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi112Copper(1+)By similarity1
Metal bindingi120Copper(1+)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator CueR
Alternative name(s):
Copper efflux regulator
Copper export regulator
Gene namesi
Name:cueR
Ordered Locus Names:Z0636, ECs0545
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981131 – 135HTH-type transcriptional regulator CueRAdd BLAST135

Proteomic databases

PRIDEiQ8XD09

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi155864.Z0636

Structurei

3D structure databases

ProteinModelPortaliQ8XD09
SMRiQ8XD09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 69HTH merR-typePROSITE-ProRule annotationAdd BLAST69

Domaini

It contains a N-terminal DNA binding region and a C-terminal metal binding region.By similarity

Phylogenomic databases

eggNOGiCOG0789 LUCA
HOGENOMiHOG000266076
KOiK19591
OMAiYDERAVH

Family and domain databases

CDDicd01108 HTH_CueR, 1 hit
InterProiView protein in InterPro
IPR011789 CueR
IPR009061 DNA-bd_dom_put_sf
IPR000551 MerR-type_HTH_dom
PfamiView protein in Pfam
PF13411 MerR_1, 1 hit
PRINTSiPR00040 HTHMERR
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR02044 CueR, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XD09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISDVAKIT GLTSKAIRFY EEKGLVTPPM RSENGYRTYT QQHLNELTLL
60 70 80 90 100
RQARQVGFNL EESGELVNLF NDPQRHSADV KRRTLEKVAE IERHIEELQS
110 120 130
MRNQLLALAN ACPGDDSADC PIIENLSGCC HHRAG
Length:135
Mass (Da):15,234
Last modified:March 1, 2002 - v1
Checksum:iADA0D919E3140862
GO

Sequence cautioni

The sequence AAG54841 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG54841.1 Different initiation.
BA000007 Genomic DNA Translation: BAB33968.1
AF288452 Genomic DNA Translation: AAN02438.1
PIRiA90697
E85547
RefSeqiNP_308572.1, NC_002695.1
WP_001026752.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG54841; AAG54841; Z0636
BAB33968; BAB33968; BAB33968
GeneIDi915192
KEGGiece:Z0636
ecs:ECs0545
PATRICifig|386585.9.peg.652

Similar proteinsi

Entry informationi

Entry nameiCUER_ECO57
AccessioniPrimary (citable) accession number: Q8XD09
Secondary accession number(s): Q8KY47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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