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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd), 6-phosphogluconate dehydrogenase, decarboxylating (ECs2830)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50NADPUniRule annotation1
Binding sitei147NADPUniRule annotation1
Binding sitei177SubstrateUniRule annotation1
Binding sitei181SubstrateUniRule annotation1
Binding sitei215SubstrateUniRule annotation1
Binding sitei234SubstrateUniRule annotation1
Active sitei239Proton acceptorUniRule annotation1
Binding sitei339SubstrateUniRule annotation1
Binding sitei344SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi92 – 93NADPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:Z2904, ECs2562
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681191 – 491Glucose-6-phosphate 1-dehydrogenaseAdd BLAST491

Proteomic databases

PRIDEiQ8XCJ6

Interactioni

Protein-protein interaction databases

STRINGi155864.Z2904

Structurei

3D structure databases

ProteinModelPortaliQ8XCJ6
SMRiQ8XCJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D8W Bacteria
COG0364 LUCA
HOGENOMiHOG000046191
KOiK00036
OMAiVEICVYE

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR019796 G6P_DH_AS
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069 G6P_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XCJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTQTAQVC DLVIFGAKGD LARRKLLPSL YQLEKAGQLN PDTRIIGVGR
60 70 80 90 100
ADWDKAAYTK VVREALETFM KETIDEGLWD TLSARLDFCN LDVNDTAAFS
110 120 130 140 150
RLGAMLDQKN RITINYFAMP PSTFGAICKG LGEAKLNAKP ARVVMEKPLG
160 170 180 190 200
TSLATSQEIN DQVGEYFEEC QVYRIDHYLG KETVLNLLAL RFANSLFVNN
210 220 230 240 250
WDNRTIDHVE ITVAEEVGIE GRWGYFDKAG QMRDMIQNHL LQILCMIAMS
260 270 280 290 300
PPSDLSADSI RDEKVKVLKS LRRIDRSNVR EKTVRGQYTA GFAQGKKVPG
310 320 330 340 350
YLEEEGANKS SNTETFVAIR VDIDNWRWAG VPFYLRTGKR LPTKCSEVVV
360 370 380 390 400
YFKTPELNLF KESWQDLPQN KLTIRLQPDE GVDIQVLNKV PGLDHKHNLQ
410 420 430 440 450
ITKLDLSYSE TFNQTHLADA YERLLLETMR GIQALFVRRD EVEEAWKWVD
460 470 480 490
SITEAWAMDN DAPKPYQAGT WGPVASVAMI TRDGRSWNEF E
Length:491
Mass (Da):55,732
Last modified:March 1, 2002 - v1
Checksum:iFEE38F456F6A7B24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG56842.1
BA000007 Genomic DNA Translation: BAB35985.1
PIRiB90949
F85797
RefSeqiNP_310589.1, NC_002695.1
WP_000301737.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG56842; AAG56842; Z2904
BAB35985; BAB35985; BAB35985
GeneIDi912956
KEGGiece:Z2904
ecs:ECs2562
PATRICifig|386585.9.peg.2685

Entry informationi

Entry nameiG6PD_ECO57
AccessioniPrimary (citable) accession number: Q8XCJ6
Secondary accession number(s): Q7AD71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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