Sensor kinase cusS - Escherichia coli O157:H7

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Reviewed, UniProtKB/Swiss-Prot Q8XBY4 (CUSS_ECO57)

Last modified November 3, 2009. Version 56. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Sensor kinase cusS
EC=2.7.13.3

Gene names

Name:	cusS
Ordered Locus Names:	Z0708, ECs0608

Organism

Escherichia coli O157:H7 [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Member of the two-component regulatory system cusS/cusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates cusR by phosphorylation By similarity.
Catalytic activity	ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Contains 1 HAMP domain. Contains 1 histidine kinase domain.

Ontologies

Keywords
Biological process	Two-component regulatory system
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Copper Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	peptidyl-histidine phosphorylation Inferred from electronic annotation. Source: InterPro sensory perception Inferred from electronic annotation. Source: InterPro two-component signal transduction system (phosphorelay) Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW two-component sensor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

482

Sensor kinase cusS

PRO_0000074726

Regions

Topological domain

15

Cytoplasmic Potential

Transmembrane

21

Potential

Topological domain

150

Periplasmic Potential

Transmembrane

21

Potential

Topological domain

275

Cytoplasmic Potential

Domain

54

HAMP

Domain

215

Histidine kinase

Amino acid modifications

Modified residue

1

Phosphohistidine; by autocatalysis By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q8XBY4-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: E2AB98ACE676DA71
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482

53,909

        10         20         30         40         50         60 
MVSKPFQRPF SLATRLTFFI SLATIAAFFA FAWIMIHSVK VHFAEQDIND LKEISATLER 

        70         80         90        100        110        120 
VLNHPDETQA RRLMTLEDIV SGYSNVLISL ADSHGKTVYH SPGAPDIREF ARDAIPDKDA 

       130        140        150        160        170        180 
RGGEVFLLSG PTMMMPGHGH GHMEHSNWRM ISLPVGPLVD GKPIYTLYIA LSIDFHLHYI 

       190        200        210        220        230        240 
NDLMNKLIMT ASVISILIVF IVLLAVHKGH APIRSVSRQI QNITSKDLDV RLDPQTVPIE 

       250        260        270        280        290        300 
LEQLVLSFNH MIERIEDVFT RQSNFSADIA HEIRTPITNL ITQTEIALSQ SRSQKELEDV 

       310        320        330        340        350        360 
LYSNLEELTR MAKMVSDMLF LAQADNNQLI PEKKMLNLAD EVGKVFDFFE ALAEDRGVEL 

       370        380        390        400        410        420 
QFVGDECQVA GDPLMLRRAL SNLLSNALRY TPPGEAIVVR CQTVDHLVQV IVENPGTPIA 

       430        440        450        460        470        480 
PEHLPRLFDR FYRVDPSRQR KGEGSGIGLA IVKSIVVAHK GTVAVTSNAR GTRFVIVLPE 


RG

References

[1]

"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7."
Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W.

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Blattner F.R.
Nature 409:529-533(2001) [PubMed: 11206551] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.

[2]

"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.

expand/collapse author list

Shinagawa H.
DNA Res. 8:11-22(2001) [PubMed: 11258796] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Cross-references

Sequence databases
	AE005174 Genomic DNA. Translation: AAG54903.1. BA000007 Genomic DNA. Translation: BAB34031.1.
PIR	C85555. H90704.
RefSeq	NP_286295.1. NP_308635.1.
3D structure databases
HSSP	HSSP built from PDB template 1BXD based on UniProtKB P02933.
ModBase	Search...
Genome annotation databases
GeneID	916966. 957566.
GenomeReviews	Gene locus Z0708 in contig AE005174_GR. Gene locus ECs0608 in contig BA000007_GR.
KEGG	ece:Z0708. ecs:ECs0608.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8XBY4.
OMA	TRETIVV.
Enzyme and pathway databases
BioCyc	ECOL83334:ECS0608-MON.
Family and domain databases
InterPro	IPR003594. ATP_bd_ATPase. IPR003660. HAMP_linker_domain. IPR004358. Sig_transdc_His_kin-like_C. IPR006290. Sig_transdc_His_kin_metal-sen. IPR003661. Sig_transdc_His_kin_sub1_dim/P. IPR005467. Sig_transdc_His_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
Pfam	PF00672. HAMP. 1 hit. PF02518. HATPase_c. 1 hit. PF00512. HisKA. 1 hit. [Graphical view]
PRINTS	PR00344. BCTRLSENSOR.
SMART	SM00304. HAMP. 1 hit. SM00387. HATPase_c. 1 hit. SM00388. HisKA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01386. cztS_silS_copS. 1 hit.
PROSITE	PS50885. HAMP. 1 hit. PS50109. HIS_KIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CUSS_ECO57

Accession

Primary (citable) accession number: Q8XBY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents