Q8XBR7 (FCTA_ECO57) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formyl-coenzyme A transferase
Short name=Formyl-CoA transferase
EC=2.8.3.16

Gene names

Name:	frc
Ordered Locus Names:	Z3639, ECs3254

Organism

Escherichia coli O157:H7 [Complete proteome] [HAMAP]

Taxonomic identifier

83334 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate By similarity. HAMAP MF_00742
Catalytic activity	Formyl-CoA + oxalate = formate + oxalyl-CoA. HAMAP MF_00742
Pathway	Metabolic intermediate degradation; oxalate degradation; CO(2) and formate from oxalate: step 1/2. HAMAP MF_00742
Subunit structure	Homodimer By similarity. HAMAP MF_00742
Sequence similarities	Belongs to the CaiB/BaiF CoA-transferase family.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	formyl-CoA transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Formyl-coenzyme A transferase HAMAP MF_00742		PRO_0000194718
Regions
	Region	17 – 18	2	Coenzyme A binding By similarity
	Region	137 – 140	4	Coenzyme A binding By similarity
Sites
	Active site	169	1	Nucleophile By similarity
	Binding site	75	1	Coenzyme A By similarity
	Binding site	96	1	Coenzyme A By similarity
	Binding site	98	1	Coenzyme A By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8XBR7 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 9702FBF0010732B1	FASTA	416	45,814
	10 20 30 40 50 60 MSTPLQGIKV LDFTGVQSGP SCTQMLAWFG ADVIKIERPG VGDVTRHQLR DIPDIDALYF 70 80 90 100 110 120 TMLNSNKRSI ELNTKTAEGK EVMEKLIREA DILVENFHPG AIDHMGFTWE HIQEINPRLI 130 140 150 160 170 180 FGSIKGFDEC SPYVNVKAYE NVAQAAGGAA STTGFWDGPP LVSAAALGDS NTGMHLLIGL 190 200 210 220 230 240 LAALLHREKT GRGQRVTMSM QDAVLNLCRV KLRDQQRLDK LGYLEEYPQY PNGTFGDAVP 250 260 270 280 290 300 RGGNAGGGGQ PGWILKCKGW ETDPNAYIYF TIQEQNWENT CKAIGKPDWI TDPAYSTAHA 310 320 330 340 350 360 RQPHIFDIFA EIEKYTVTID KHEAVAYLTQ FDIPCAPVLS MKEISLDPSL RQSGSVVEVE 370 380 390 400 410 QPLRGKYLTV GCPMKFSAFT PDIKAAPLLG EHTAAVLQEL GYSDDEIAAM KQNHAI

References

[1]

"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. , Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R. Nature 409:529-533(2001) [PubMed: 11206551] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.

[2]

"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. , Kuhara S., Shiba T., Hattori M., Shinagawa H. DNA Res. 8:11-22(2001) [PubMed: 11258796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005174 Genomic DNA. Translation: AAG57500.1. BA000007 Genomic DNA. Translation: BAB36677.1.
PIR	F91035. H85879.
RefSeq	NP_288944.1. NC_002655.2. NP_311281.1. NC_002695.1.
3D structure databases
ProteinModelPortal	Q8XBR7.
SMR	Q8XBR7. Positions 2-416.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000028277; EBESCP00000027170; EBESCG00000027328. EBESCT00000056511; EBESCP00000054339; EBESCG00000055559.
GeneID	915645. 957557.
GenomeReviews	Gene locus Z3639 in contig AE005174_GR. Gene locus ECs3254 in contig BA000007_GR.
KEGG	ece:Z3639. ecs:ECs3254.
PATRIC	18355908. VBIEscCol44059_3154.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000009654.
HOGENOM	HBG659028.
OMA	DEWANDP.
ProtClustDB	PRK05398.
Enzyme and pathway databases
BioCyc	ECOL83334:ECS3254-MONOMER.
Family and domain databases
HAMAP	MF_00742. Formyl-CoA_transfer. [Tree]
InterPro	IPR003673. CoA-Trfase_fam_III. IPR023606. CoA-Trfase_III_dom. IPR017659. Formyl-CoA_transferase. [Graphical view]
Gene3D	G3DSA:3.40.50.10540. CoA-Trfase_fam_III. 1 hit.
KO	K07749.
PANTHER	PTHR11837. CAIB_BAIF. 1 hit.
Pfam	PF02515. CoA_transf_3. 1 hit. [Graphical view]
SUPFAM	SSF89796. CoA-Trfase_fam_III. 1 hit.
TIGRFAMs	TIGR03253. Oxalate_frc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FCTA_ECO57

Accession

Primary (citable) accession number: Q8XBR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program