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Protein

L(+)-tartrate dehydratase subunit beta

Gene

ttdB

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(R,R)-tartrate = oxaloacetate + H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Sequence Analysis

GO - Molecular functioni

  1. L(+)-tartrate dehydratase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3904-MONOMER.
ECOO157:TTDB-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L(+)-tartrate dehydratase subunit beta (EC:4.2.1.32)
Short name:
L-TTD beta
Gene namesi
Name:ttdB
Ordered Locus Names:Z4415, ECs3945
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558 Componenti: Chromosome UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201L(+)-tartrate dehydratase subunit betaPRO_0000195665Add
BLAST

Expressioni

Inductioni

Induced by tartrate, via TtdR.By similarity

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi155864.Z4415.

Structurei

3D structure databases

ProteinModelPortaliQ8XBK5.
SMRiQ8XBK5. Positions 1-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I fumarase family.Curated

Phylogenomic databases

eggNOGiCOG1838.
HOGENOMiHOG000225718.
KOiK03780.
OMAiVENFGPL.
OrthoDBiEOG6TXR10.

Family and domain databases

Gene3Di3.20.130.10. 1 hit.
InterProiIPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
[Graphical view]
PfamiPF05683. Fumerase_C. 1 hit.
[Graphical view]
SUPFAMiSSF117457. SSF117457. 1 hit.
TIGRFAMsiTIGR00723. ttdB_fumA_fumB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XBK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKILTTPIK AEDLQDIHVG DVIYLTGTLV TCRDVCHRRL IELKRPLPYD
60 70 80 90 100
LNGKAIFHAG PIVRKNGDKW EMVSVGPTTS MRMESFEREF IEQTGVKLVV
110 120 130 140 150
GKGGMGPLTE EGCQKFKALH VIFPAGCAVL AATQVEEIEE VHWTELGMPE
160 170 180 190 200
SLWVCRVKEF GPLIVSIDTH GNNLIAENKK LFAERRDPIV EEICEHVHYI

K
Length:201
Mass (Da):22,660
Last modified:March 1, 2002 - v1
Checksum:i451BA605C388F157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG58196.1.
BA000007 Genomic DNA. Translation: BAB37368.1.
PIRiA91122.
H85966.
RefSeqiNP_289637.1. NC_002655.2.
NP_311972.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG58196; AAG58196; Z4415.
BAB37368; BAB37368; BAB37368.
GeneIDi916229.
958372.
KEGGiece:Z4415.
ecs:ECs3945.
PATRICi18357385. VBIEscCol44059_3870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG58196.1.
BA000007 Genomic DNA. Translation: BAB37368.1.
PIRiA91122.
H85966.
RefSeqiNP_289637.1. NC_002655.2.
NP_311972.1. NC_002695.1.

3D structure databases

ProteinModelPortaliQ8XBK5.
SMRiQ8XBK5. Positions 1-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z4415.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG58196; AAG58196; Z4415.
BAB37368; BAB37368; BAB37368.
GeneIDi916229.
958372.
KEGGiece:Z4415.
ecs:ECs3945.
PATRICi18357385. VBIEscCol44059_3870.

Phylogenomic databases

eggNOGiCOG1838.
HOGENOMiHOG000225718.
KOiK03780.
OMAiVENFGPL.
OrthoDBiEOG6TXR10.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3904-MONOMER.
ECOO157:TTDB-MONOMER.

Family and domain databases

Gene3Di3.20.130.10. 1 hit.
InterProiIPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
[Graphical view]
PfamiPF05683. Fumerase_C. 1 hit.
[Graphical view]
SUPFAMiSSF117457. SSF117457. 1 hit.
TIGRFAMsiTIGR00723. ttdB_fumA_fumB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiTTDB_ECO57
AccessioniPrimary (citable) accession number: Q8XBK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2002
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.