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Q8XBK5

- TTDB_ECO57

UniProt

Q8XBK5 - TTDB_ECO57

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Protein
L(+)-tartrate dehydratase subunit beta
Gene
ttdB, Z4415, ECs3945
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(R,R)-tartrate = oxaloacetate + H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371 Reviewed prediction

GO - Molecular functioni

  1. L(+)-tartrate dehydratase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3904-MONOMER.
ECOO157:TTDB-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L(+)-tartrate dehydratase subunit beta (EC:4.2.1.32)
Short name:
L-TTD beta
Gene namesi
Name:ttdB
Ordered Locus Names:Z4415, ECs3945
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201L(+)-tartrate dehydratase subunit beta
PRO_0000195665Add
BLAST

Expressioni

Inductioni

Induced by tartrate, via TtdR By similarity.

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi155864.Z4415.

Structurei

3D structure databases

ProteinModelPortaliQ8XBK5.
SMRiQ8XBK5. Positions 1-177.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I fumarase family.

Phylogenomic databases

eggNOGiCOG1838.
HOGENOMiHOG000225718.
KOiK03780.
OMAiEWQDLGM.
OrthoDBiEOG6TXR10.

Family and domain databases

Gene3Di3.20.130.10. 1 hit.
InterProiIPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
[Graphical view]
PfamiPF05683. Fumerase_C. 1 hit.
[Graphical view]
SUPFAMiSSF117457. SSF117457. 1 hit.
TIGRFAMsiTIGR00723. ttdB_fumA_fumB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XBK5-1 [UniParc]FASTAAdd to Basket

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MKKILTTPIK AEDLQDIHVG DVIYLTGTLV TCRDVCHRRL IELKRPLPYD    50
LNGKAIFHAG PIVRKNGDKW EMVSVGPTTS MRMESFEREF IEQTGVKLVV 100
GKGGMGPLTE EGCQKFKALH VIFPAGCAVL AATQVEEIEE VHWTELGMPE 150
SLWVCRVKEF GPLIVSIDTH GNNLIAENKK LFAERRDPIV EEICEHVHYI 200
K 201
Length:201
Mass (Da):22,660
Last modified:March 1, 2002 - v1
Checksum:i451BA605C388F157
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58196.1.
BA000007 Genomic DNA. Translation: BAB37368.1.
PIRiA91122.
H85966.
RefSeqiNP_289637.1. NC_002655.2.
NP_311972.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG58196; AAG58196; Z4415.
BAB37368; BAB37368; BAB37368.
GeneIDi916229.
958372.
KEGGiece:Z4415.
ecs:ECs3945.
PATRICi18357385. VBIEscCol44059_3870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58196.1 .
BA000007 Genomic DNA. Translation: BAB37368.1 .
PIRi A91122.
H85966.
RefSeqi NP_289637.1. NC_002655.2.
NP_311972.1. NC_002695.1.

3D structure databases

ProteinModelPortali Q8XBK5.
SMRi Q8XBK5. Positions 1-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z4415.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG58196 ; AAG58196 ; Z4415 .
BAB37368 ; BAB37368 ; BAB37368 .
GeneIDi 916229.
958372.
KEGGi ece:Z4415.
ecs:ECs3945.
PATRICi 18357385. VBIEscCol44059_3870.

Phylogenomic databases

eggNOGi COG1838.
HOGENOMi HOG000225718.
KOi K03780.
OMAi EWQDLGM.
OrthoDBi EOG6TXR10.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-3904-MONOMER.
ECOO157:TTDB-MONOMER.

Family and domain databases

Gene3Di 3.20.130.10. 1 hit.
InterProi IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
[Graphical view ]
Pfami PF05683. Fumerase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF117457. SSF117457. 1 hit.
TIGRFAMsi TIGR00723. ttdB_fumA_fumB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiTTDB_ECO57
AccessioniPrimary (citable) accession number: Q8XBK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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