Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

D-cysteine desulfhydrase

Gene

dcyD

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.UniRule annotation

Catalytic activityi

D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionLyase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
D-cysteine desulfhydraseUniRule annotation (EC:4.4.1.15UniRule annotation)
Gene namesi
Name:dcyDUniRule annotation
Ordered Locus Names:Z3008, ECs2657/ECs2658
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001845152 – 328D-cysteine desulfhydraseAdd BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z3008

Structurei

3D structure databases

ProteinModelPortaliQ8XBC7
SMRiQ8XBC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K6H Bacteria
COG2515 LUCA
HOGENOMiHOG000022459
KOiK05396
OMAiAKIGMKC

Family and domain databases

HAMAPiMF_01045 D_Cys_desulfhydr, 1 hit
InterProiView protein in InterPro
IPR027278 ACCD_DCysDesulf
IPR005966 D-Cys_desShydrase
IPR023702 D_Cys_desulphydr_bac
IPR001926 PLP-dep
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF006278 ACCD_DCysDesulf, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR01275 ACC_deam_rel, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8XBC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLHNLTRFP RLEFIGAPTP LEYLPRFSDY LGREIFIKRD DVTPMAMGGN
60 70 80 90 100
KLRKLEFLAA DALREGADTL ITAGAIQSNH VRQTAAVAAK LGLHCVALLE
110 120 130 140 150
NPIGTTAENY LTNGNRLLLD LFNTQIEMCD ALTDPNAQLE ELATRVEAQG
160 170 180 190 200
FRPYVIPVGG SNALGALGYV ESALEIAQQC EGAVNISSVV VASGSAGTHA
210 220 230 240 250
GLAVGLEHLM PESELIGVTV SRSVADQLPK VVNLQQAIAK ELELTASVEI
260 270 280 290 300
LLWDDYFAPG YGVPNDEGME AVKLLARLEG ILLDPVYTGK AMAGLIDGIS
310 320
QKRFKDEGPI LFIHTGGAPA LFAYHPHV
Length:328
Mass (Da):35,181
Last modified:January 23, 2007 - v3
Checksum:i59D6392CF3EC62D8
GO

Sequence cautioni

The sequence AAG56934 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB36080 differs from that shown. Reason: Frameshift at position 139. Produces two separate ORFs.Curated
The sequence BAB36081 differs from that shown. Reason: Frameshift at position 139. Produces two separate ORFs.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG56934.1 Different initiation.
BA000007 Genomic DNA Translation: BAB36080.1 Frameshift.
BA000007 Genomic DNA Translation: BAB36081.1 Frameshift.
PIRiA90961
B85809
B90961
RefSeqiWP_001128225.1, NZ_MWVM01000031.1

Genome annotation databases

EnsemblBacteriaiAAG56934; AAG56934; Z3008
BAB36080; BAB36080; BAB36080
BAB36081; BAB36081; BAB36081
KEGGiece:Z3008
PATRICifig|83334.175.peg.615

Similar proteinsi

Entry informationi

Entry nameiDCYD_ECO57
AccessioniPrimary (citable) accession number: Q8XBC7
Secondary accession number(s): Q8X2H0, Q8X2H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 90 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health