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Q8XBC7

- DCYD_ECO57

UniProt

Q8XBC7 - DCYD_ECO57

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Protein
D-cysteine desulfhydrase
Gene
dcyD, Z3008, ECs2657/ECs2658
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine By similarity.UniRule annotation

Catalytic activityi

D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. D-cysteine desulfhydrase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-amino acid metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
D-cysteine desulfhydrase (EC:4.4.1.15)
Gene namesi
Name:dcyD
Ordered Locus Names:Z3008, ECs2657/ECs2658
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 328327D-cysteine desulfhydraseUniRule annotation
PRO_0000184515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ8XBC7.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z3008.

Structurei

3D structure databases

ProteinModelPortaliQ8XBC7.
SMRiQ8XBC7. Positions 4-327.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000022459.
KOiK05396.
OMAiPYLVPIG.
OrthoDBiEOG6FBX0P.

Family and domain databases

HAMAPiMF_01045. D_Cys_desulfhydr.
InterProiIPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8XBC7-1 [UniParc]FASTAAdd to Basket

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MPLHNLTRFP RLEFIGAPTP LEYLPRFSDY LGREIFIKRD DVTPMAMGGN    50
KLRKLEFLAA DALREGADTL ITAGAIQSNH VRQTAAVAAK LGLHCVALLE 100
NPIGTTAENY LTNGNRLLLD LFNTQIEMCD ALTDPNAQLE ELATRVEAQG 150
FRPYVIPVGG SNALGALGYV ESALEIAQQC EGAVNISSVV VASGSAGTHA 200
GLAVGLEHLM PESELIGVTV SRSVADQLPK VVNLQQAIAK ELELTASVEI 250
LLWDDYFAPG YGVPNDEGME AVKLLARLEG ILLDPVYTGK AMAGLIDGIS 300
QKRFKDEGPI LFIHTGGAPA LFAYHPHV 328
Length:328
Mass (Da):35,181
Last modified:January 23, 2007 - v3
Checksum:i59D6392CF3EC62D8
GO

Sequence cautioni

The sequence BAB36080.1 differs from that shown. Reason: Frameshift at position 139. Produces two separate ORFs.
The sequence BAB36081.1 differs from that shown. Reason: Frameshift at position 139. Produces two separate ORFs.
The sequence AAG56934.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG56934.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB36080.1. Frameshift.
BA000007 Genomic DNA. Translation: BAB36081.1. Frameshift.
PIRiA90961.
B85809.
B90961.
RefSeqiNP_288380.2. NC_002655.2.

Genome annotation databases

EnsemblBacteriaiAAG56934; AAG56934; Z3008.
BAB36080; BAB36080; BAB36080.
BAB36081; BAB36081; BAB36081.
GeneIDi961917.
KEGGiece:Z3008.
PATRICi18354700. VBIEscCol44059_2558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG56934.1 . Different initiation.
BA000007 Genomic DNA. Translation: BAB36080.1 . Frameshift.
BA000007 Genomic DNA. Translation: BAB36081.1 . Frameshift.
PIRi A90961.
B85809.
B90961.
RefSeqi NP_288380.2. NC_002655.2.

3D structure databases

ProteinModelPortali Q8XBC7.
SMRi Q8XBC7. Positions 4-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z3008.

Proteomic databases

PRIDEi Q8XBC7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG56934 ; AAG56934 ; Z3008 .
BAB36080 ; BAB36080 ; BAB36080 .
BAB36081 ; BAB36081 ; BAB36081 .
GeneIDi 961917.
KEGGi ece:Z3008.
PATRICi 18354700. VBIEscCol44059_2558.

Phylogenomic databases

HOGENOMi HOG000022459.
KOi K05396.
OMAi PYLVPIG.
OrthoDBi EOG6FBX0P.

Family and domain databases

HAMAPi MF_01045. D_Cys_desulfhydr.
InterProi IPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR01275. ACC_deam_rel. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiDCYD_ECO57
AccessioniPrimary (citable) accession number: Q8XBC7
Secondary accession number(s): Q8X2H0, Q8X2H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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