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Q8XB43

- RNPA_ECO57

UniProt

Q8XB43 - RNPA_ECO57

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Protein

Ribonuclease P protein component

Gene
rnpA, Z5195, ECs4639
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-EC
  2. tRNA binding Source: InterPro

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4607-MONOMER.
ECOO157:RNPA-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein component (EC:3.1.26.5)
Short name:
RNase P protein
Short name:
RNaseP protein
Alternative name(s):
Protein C5
Gene namesi
Name:rnpA
Ordered Locus Names:Z5195, ECs4639
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Ribonuclease P protein componentUniRule annotationPRO_0000198459Add
BLAST

Interactioni

Subunit structurei

Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit By similarity.

Protein-protein interaction databases

STRINGi155864.Z5195.

Structurei

3D structure databases

ProteinModelPortaliQ8XB43.
SMRiQ8XB43. Positions 5-112.

Family & Domainsi

Sequence similaritiesi

Belongs to the RnpA family.

Phylogenomic databases

eggNOGiCOG0594.
HOGENOMiHOG000266301.
KOiK03536.
OMAiPPMDFVV.
OrthoDBiEOG6C01C6.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
HAMAPiMF_00227. RNase_P.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
IPR020539. RNase_P_CS.
[Graphical view]
PfamiPF00825. Ribonuclease_P. 1 hit.
[Graphical view]
ProDomiPD003629. Ribonuclease_P. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00188. rnpA. 1 hit.
PROSITEiPS00648. RIBONUCLEASE_P. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8XB43-1 [UniParc]FASTAAdd to Basket

« Hide

MVKLAFPREL RLLTPSQFTF VFQQPQRAGT PQITILGRLN SLGHPRIGLT    50
VAKKNVRRAH ERNRIKRLTR ESFRLRQHEL PAMDFVVVAK KGVANLDNRA 100
LSEALEKLWR RHCRLARGS 119
Length:119
Mass (Da):13,788
Last modified:March 1, 2002 - v1
Checksum:i4E3D34DACA1C6240
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58901.1.
BA000007 Genomic DNA. Translation: BAB38062.1.
PIRiA86055.
G91208.
RefSeqiNP_290337.1. NC_002655.2.
NP_312666.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG58901; AAG58901; Z5195.
BAB38062; BAB38062; BAB38062.
GeneIDi915401.
960752.
KEGGiece:Z5195.
ecs:ECs4639.
PATRICi18358885. VBIEscCol44059_4607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58901.1 .
BA000007 Genomic DNA. Translation: BAB38062.1 .
PIRi A86055.
G91208.
RefSeqi NP_290337.1. NC_002655.2.
NP_312666.1. NC_002695.1.

3D structure databases

ProteinModelPortali Q8XB43.
SMRi Q8XB43. Positions 5-112.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z5195.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG58901 ; AAG58901 ; Z5195 .
BAB38062 ; BAB38062 ; BAB38062 .
GeneIDi 915401.
960752.
KEGGi ece:Z5195.
ecs:ECs4639.
PATRICi 18358885. VBIEscCol44059_4607.

Phylogenomic databases

eggNOGi COG0594.
HOGENOMi HOG000266301.
KOi K03536.
OMAi PPMDFVV.
OrthoDBi EOG6C01C6.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-4607-MONOMER.
ECOO157:RNPA-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
HAMAPi MF_00227. RNase_P.
InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
IPR020539. RNase_P_CS.
[Graphical view ]
Pfami PF00825. Ribonuclease_P. 1 hit.
[Graphical view ]
ProDomi PD003629. Ribonuclease_P. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF54211. SSF54211. 1 hit.
TIGRFAMsi TIGR00188. rnpA. 1 hit.
PROSITEi PS00648. RIBONUCLEASE_P. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiRNPA_ECO57
AccessioniPrimary (citable) accession number: Q8XB43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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