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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi: ppGpp biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes ppGpp from GTP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. GTP pyrophosphokinase (relA)
  2. Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA)
This subpathway is part of the pathway ppGpp biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ppGpp from GTP, the pathway ppGpp biosynthesis and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00908; UER00885

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:Z5289, ECs4712
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001942811 – 494Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseAdd BLAST494

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5289

Structurei

3D structure databases

ProteinModelPortaliQ8XAT5
SMRiQ8XAT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9X Bacteria
COG0248 LUCA
HOGENOMiHOG000258672
KOiK01524
OMAiWQICVGA

Family and domain databases

HAMAPiMF_01550 GppA, 1 hit
InterProiView protein in InterPro
IPR023709 Guo-5TP_3DP_PyrP
IPR003695 Ppx_GppA
IPR030673 PyroPPase_GppA_Ppx
PfamiView protein in Pfam
PF02541 Ppx-GppA, 1 hit
PIRSFiPIRSF001267 Pyrophosphatase_GppA_Ppx, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XAT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSTSSLYAA IDLGSNSFHM LVVREVAGSI QTLTRIKRKV RLAAGLNSEN
60 70 80 90 100
ALSNEAMERG WQCLRLFAER LQDIPPSQIR VVATATLRLA VNAGDFIAKA
110 120 130 140 150
QEILGCPVQV ISGEEEARLI YQGVAHTTGG ADQRLVVDIG GASTELVTGT
160 170 180 190 200
GAQTTSLFSL SMGCVTWLER YFADRNLGQE NFDAAEKAAR EVLRPVADEL
210 220 230 240 250
RYHGWKVCVG ASGTVQALQE IMMAQGMDER ITLEKLQQLK QRAIHCGRLE
260 270 280 290 300
ELEIDGLTLE RALVFPSGLA ILIAIFTELN IQCMTLAGGA LREGLVYGML
310 320 330 340 350
HLAVEQDIRS RTLRNIQRRF MIDIDQAQRV AKVAANFFDQ VENEWHLEAI
360 370 380 390 400
SRDLLISACQ LHEIGLSVDF KQAPQHAAYL VRNLDLPGFT PAQKKLLATL
410 420 430 440 450
LLNQTNPVDL SSLHQQNAVP PRVAEQLCRL LRLAIIFASR RRDDLVPEMT
460 470 480 490
LQANHELLTL TLPQGWLTQH PLGKEIIAQE SQWQSYVHWP LEVH
Length:494
Mass (Da):54,871
Last modified:March 1, 2002 - v1
Checksum:iC4DD8DC59432A5F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58973.1
BA000007 Genomic DNA Translation: BAB38135.1
PIRiA86064
H91217
RefSeqiNP_312739.1, NC_002695.1
WP_001295254.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG58973; AAG58973; Z5289
BAB38135; BAB38135; BAB38135
GeneIDi915259
KEGGiece:Z5289
ecs:ECs4712
PATRICifig|386585.9.peg.4916

Similar proteinsi

Entry informationi

Entry nameiGPPA_ECO57
AccessioniPrimary (citable) accession number: Q8XAT5
Secondary accession number(s): Q7A9F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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