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Q8XAT5

- GPPA_ECO57

UniProt

Q8XAT5 - GPPA_ECO57

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4686-MONOMER.
ECOO157:GPPA-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:Z5289, ECs4712
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194281Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5289.

Structurei

3D structure databases

ProteinModelPortaliQ8XAT5.
SMRiQ8XAT5. Positions 8-493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8XAT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSTSSLYAA IDLGSNSFHM LVVREVAGSI QTLTRIKRKV RLAAGLNSEN
60 70 80 90 100
ALSNEAMERG WQCLRLFAER LQDIPPSQIR VVATATLRLA VNAGDFIAKA
110 120 130 140 150
QEILGCPVQV ISGEEEARLI YQGVAHTTGG ADQRLVVDIG GASTELVTGT
160 170 180 190 200
GAQTTSLFSL SMGCVTWLER YFADRNLGQE NFDAAEKAAR EVLRPVADEL
210 220 230 240 250
RYHGWKVCVG ASGTVQALQE IMMAQGMDER ITLEKLQQLK QRAIHCGRLE
260 270 280 290 300
ELEIDGLTLE RALVFPSGLA ILIAIFTELN IQCMTLAGGA LREGLVYGML
310 320 330 340 350
HLAVEQDIRS RTLRNIQRRF MIDIDQAQRV AKVAANFFDQ VENEWHLEAI
360 370 380 390 400
SRDLLISACQ LHEIGLSVDF KQAPQHAAYL VRNLDLPGFT PAQKKLLATL
410 420 430 440 450
LLNQTNPVDL SSLHQQNAVP PRVAEQLCRL LRLAIIFASR RRDDLVPEMT
460 470 480 490
LQANHELLTL TLPQGWLTQH PLGKEIIAQE SQWQSYVHWP LEVH
Length:494
Mass (Da):54,871
Last modified:March 1, 2002 - v1
Checksum:iC4DD8DC59432A5F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58973.1.
BA000007 Genomic DNA. Translation: BAB38135.1.
PIRiA86064.
H91217.
RefSeqiNP_290409.1. NC_002655.2.
NP_312739.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG58973; AAG58973; Z5289.
BAB38135; BAB38135; BAB38135.
GeneIDi915259.
960391.
KEGGiece:Z5289.
ecs:ECs4712.
PATRICi18359031. VBIEscCol44059_4674.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58973.1 .
BA000007 Genomic DNA. Translation: BAB38135.1 .
PIRi A86064.
H91217.
RefSeqi NP_290409.1. NC_002655.2.
NP_312739.1. NC_002695.1.

3D structure databases

ProteinModelPortali Q8XAT5.
SMRi Q8XAT5. Positions 8-493.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z5289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG58973 ; AAG58973 ; Z5289 .
BAB38135 ; BAB38135 ; BAB38135 .
GeneIDi 915259.
960391.
KEGGi ece:Z5289.
ecs:ECs4712.
PATRICi 18359031. VBIEscCol44059_4674.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci ECOL386585:GJFA-4686-MONOMER.
ECOO157:GPPA-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiGPPA_ECO57
AccessioniPrimary (citable) accession number: Q8XAT5
Secondary accession number(s): Q7A9F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3