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Q8XAP1

- CYAA_ECO57

UniProt

Q8XAP1 - CYAA_ECO57

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Protein
Adenylate cyclase
Gene
cyaA, Z5322, ECs4736
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. adenylate cyclase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-4717-MONOMER.
    ECOO157:CYAA-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase
    Adenylyl cyclase
    Gene namesi
    Name:cyaA
    Ordered Locus Names:Z5322, ECs4736
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 848848Adenylate cyclase
    PRO_0000195671Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei609 – 6091Phosphohistidine; by CRR Reviewed prediction

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi155864.Z5322.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 535535Catalytic
    Add
    BLAST
    Regioni541 – 848308Regulatory
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3072.
    HOGENOMiHOG000270910.
    KOiK05851.
    OMAiSEGFLQF.
    OrthoDBiEOG63JR9H.

    Family and domain databases

    InterProiIPR000274. Adenylate_cyclase_1.
    IPR024686. Adenylate_cyclase_1_CS.
    IPR024685. Adenylate_cyclase_1_N.
    [Graphical view]
    PfamiPF12633. Adenyl_cycl_N. 1 hit.
    PF01295. Adenylate_cycl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
    PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
    PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8XAP1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQQVYSLLPT LLHYHHPLMP    50
    GYLDGNVPKG ICLYTPDETQ RHYLNELELY RGMSVQDPPK GELPITGVYT 100
    MGSTSSVGQS CSSDLDIWVC HQSWLDSEER QLLQRKCSLL ESWAASLGVE 150
    VSFFLIDENR FRHNESGSLG GEDCGSTQHI LLLDEFYRTA VRLAGKRILW 200
    NMVPCDEEEH YDDYVMTLYA QGVLTPNEWL DLGGLSSLSA EEYFGASLWQ 250
    LYKSIDSPYK AVLKTLLLEA YSWEYPNPRL LAKDIKQRLH DGEIVSFGLD 300
    PYCMMLERVT EYLTAIEDFT RLDLVRRCFY LKVCEKLSRE RACVGWRRAV 350
    LSQLVSEWGW DEARLAMLDN RANWKIDQVR EAHNELLDAM MQSYRNLIRF 400
    ARRNNLSVSA SPQDIGVLTR KLYAAFEALP GKVTLVNPQI SPDLSEPNLT 450
    FIYVPPGRAN RSGWYLYNRA PNIESIISHQ PLEYNRYLNK LVAWAWFNGL 500
    LTSRTRLYIK GNGIVDLPKL QEMVADVSHH FPLRLPAPTP KALYSPCEIR 550
    HLAIIVNLEY DPTAAFRNQV VHFDFRKLDV FSFGENQNCL VGSVDLLYRN 600
    SWNEVRTLHF NGEQSMIEAL KTILGKMHQD AAPPDSVEVF CYSQHLRGLI 650
    RTRVQQLVSE CIELRLSSTR QETGRFKALR VSGQTWGLFF ERLNVSVQKL 700
    ENAIEFYGAI SHNKLHGLSV QVETNHVKLP AVVDGFASEG IIQFFFEETQ 750
    DENGFNIYIL DESNRVEVYH HCEGSKEELV RDVSRFYSSS HDRFTYGSSF 800
    INFNLPQFYQ IVKVDGREQV IPFRTKSIGN MPPANQDHDT PLLQQYFS 848
    Length:848
    Mass (Da):97,559
    Last modified:March 1, 2002 - v1
    Checksum:iBFEBE3547FBEE1C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG58998.1.
    BA000007 Genomic DNA. Translation: BAB38159.1.
    PIRiB86067.
    H91220.
    RefSeqiNP_290434.1. NC_002655.2.
    NP_312763.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG58998; AAG58998; Z5322.
    BAB38159; BAB38159; BAB38159.
    GeneIDi915191.
    960357.
    KEGGiece:Z5322.
    ecs:ECs4736.
    PATRICi18359091. VBIEscCol44059_4700.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG58998.1 .
    BA000007 Genomic DNA. Translation: BAB38159.1 .
    PIRi B86067.
    H91220.
    RefSeqi NP_290434.1. NC_002655.2.
    NP_312763.1. NC_002695.1.

    3D structure databases

    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 155864.Z5322.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG58998 ; AAG58998 ; Z5322 .
    BAB38159 ; BAB38159 ; BAB38159 .
    GeneIDi 915191.
    960357.
    KEGGi ece:Z5322.
    ecs:ECs4736.
    PATRICi 18359091. VBIEscCol44059_4700.

    Phylogenomic databases

    eggNOGi COG3072.
    HOGENOMi HOG000270910.
    KOi K05851.
    OMAi SEGFLQF.
    OrthoDBi EOG63JR9H.

    Enzyme and pathway databases

    BioCyci ECOL386585:GJFA-4717-MONOMER.
    ECOO157:CYAA-MONOMER.

    Family and domain databases

    InterProi IPR000274. Adenylate_cyclase_1.
    IPR024686. Adenylate_cyclase_1_CS.
    IPR024685. Adenylate_cyclase_1_N.
    [Graphical view ]
    Pfami PF12633. Adenyl_cycl_N. 1 hit.
    PF01295. Adenylate_cycl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001444. Adenylate_cycl. 1 hit.
    PROSITEi PS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
    PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiCYAA_ECO57
    AccessioniPrimary (citable) accession number: Q8XAP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: March 1, 2002
    Last modified: May 14, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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