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Q8XAP1

- CYAA_ECO57

UniProt

Q8XAP1 - CYAA_ECO57

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Protein

Adenylate cyclase

Gene
cyaA, Z5322, ECs4736
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

GO - Molecular functioni

  1. adenylate cyclase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4717-MONOMER.
ECOO157:CYAA-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene namesi
Name:cyaA
Ordered Locus Names:Z5322, ECs4736
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 848848Adenylate cyclasePRO_0000195671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei609 – 6091Phosphohistidine; by CRR Reviewed prediction

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5322.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 535535CatalyticAdd
BLAST
Regioni541 – 848308RegulatoryAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3072.
HOGENOMiHOG000270910.
KOiK05851.
OMAiSEGFLQF.
OrthoDBiEOG63JR9H.

Family and domain databases

InterProiIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamiPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8XAP1-1 [UniParc]FASTAAdd to Basket

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MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQQVYSLLPT LLHYHHPLMP    50
GYLDGNVPKG ICLYTPDETQ RHYLNELELY RGMSVQDPPK GELPITGVYT 100
MGSTSSVGQS CSSDLDIWVC HQSWLDSEER QLLQRKCSLL ESWAASLGVE 150
VSFFLIDENR FRHNESGSLG GEDCGSTQHI LLLDEFYRTA VRLAGKRILW 200
NMVPCDEEEH YDDYVMTLYA QGVLTPNEWL DLGGLSSLSA EEYFGASLWQ 250
LYKSIDSPYK AVLKTLLLEA YSWEYPNPRL LAKDIKQRLH DGEIVSFGLD 300
PYCMMLERVT EYLTAIEDFT RLDLVRRCFY LKVCEKLSRE RACVGWRRAV 350
LSQLVSEWGW DEARLAMLDN RANWKIDQVR EAHNELLDAM MQSYRNLIRF 400
ARRNNLSVSA SPQDIGVLTR KLYAAFEALP GKVTLVNPQI SPDLSEPNLT 450
FIYVPPGRAN RSGWYLYNRA PNIESIISHQ PLEYNRYLNK LVAWAWFNGL 500
LTSRTRLYIK GNGIVDLPKL QEMVADVSHH FPLRLPAPTP KALYSPCEIR 550
HLAIIVNLEY DPTAAFRNQV VHFDFRKLDV FSFGENQNCL VGSVDLLYRN 600
SWNEVRTLHF NGEQSMIEAL KTILGKMHQD AAPPDSVEVF CYSQHLRGLI 650
RTRVQQLVSE CIELRLSSTR QETGRFKALR VSGQTWGLFF ERLNVSVQKL 700
ENAIEFYGAI SHNKLHGLSV QVETNHVKLP AVVDGFASEG IIQFFFEETQ 750
DENGFNIYIL DESNRVEVYH HCEGSKEELV RDVSRFYSSS HDRFTYGSSF 800
INFNLPQFYQ IVKVDGREQV IPFRTKSIGN MPPANQDHDT PLLQQYFS 848
Length:848
Mass (Da):97,559
Last modified:March 1, 2002 - v1
Checksum:iBFEBE3547FBEE1C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58998.1.
BA000007 Genomic DNA. Translation: BAB38159.1.
PIRiB86067.
H91220.
RefSeqiNP_290434.1. NC_002655.2.
NP_312763.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG58998; AAG58998; Z5322.
BAB38159; BAB38159; BAB38159.
GeneIDi915191.
960357.
KEGGiece:Z5322.
ecs:ECs4736.
PATRICi18359091. VBIEscCol44059_4700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58998.1 .
BA000007 Genomic DNA. Translation: BAB38159.1 .
PIRi B86067.
H91220.
RefSeqi NP_290434.1. NC_002655.2.
NP_312763.1. NC_002695.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z5322.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG58998 ; AAG58998 ; Z5322 .
BAB38159 ; BAB38159 ; BAB38159 .
GeneIDi 915191.
960357.
KEGGi ece:Z5322.
ecs:ECs4736.
PATRICi 18359091. VBIEscCol44059_4700.

Phylogenomic databases

eggNOGi COG3072.
HOGENOMi HOG000270910.
KOi K05851.
OMAi SEGFLQF.
OrthoDBi EOG63JR9H.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-4717-MONOMER.
ECOO157:CYAA-MONOMER.

Family and domain databases

InterProi IPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view ]
Pfami PF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view ]
PIRSFi PIRSF001444. Adenylate_cycl. 1 hit.
PROSITEi PS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiCYAA_ECO57
AccessioniPrimary (citable) accession number: Q8XAP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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