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Protein

G/U mismatch-specific DNA glycosylase

Gene

mug

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.UniRule annotation

Catalytic activityi

Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase
Biological processDNA damage, DNA excision, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
G/U mismatch-specific DNA glycosylaseUniRule annotation (EC:3.2.2.28UniRule annotation)
Alternative name(s):
Double-strand-specific uracil glycosylaseUniRule annotation
Mismatch-specific uracil DNA-glycosylaseUniRule annotation
Short name:
MUGUniRule annotation
Gene namesi
Name:mugUniRule annotation
Ordered Locus Names:Z4421, ECs3951
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002386801 – 168G/U mismatch-specific DNA glycosylaseAdd BLAST168

Interactioni

Subunit structurei

Binds DNA as a monomer.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z4421

Structurei

3D structure databases

ProteinModelPortaliQ8XAN4
SMRiQ8XAN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108VCA Bacteria
COG3663 LUCA
HOGENOMiHOG000264684
KOiK03649
OMAiTGHHFAR

Family and domain databases

CDDicd10028 UDG_F2_MUG, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_01956 MUG, 1 hit
InterProiView protein in InterPro
IPR015637 MUG/TDG
IPR023502 MUG_bact
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR12159 PTHR12159, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XAN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEDILAPGL RVVFCGINPG LSSAGTGFPF AHPANRFWKV IYQAGFTDHQ
60 70 80 90 100
LKPQEAQHLL DYRCGVTKLV DRPTVQANEI SKQELHAGGR KLIEKIEDYQ
110 120 130 140 150
PQALAILGKQ AYEQGFSQRG AQWGKQTLSI GSTQIWVLPN PSGLSRVSLE
160
KLVEAYRELD QALVVRGR
Length:168
Mass (Da):18,654
Last modified:March 1, 2002 - v1
Checksum:i29E3EEDFCF3439A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000007 Genomic DNA Translation: BAB37374.1
AE005174 Genomic DNA Translation: AAG58202.1
PIRiF85967
G91122
RefSeqiNP_311978.1, NC_002695.1
WP_000228926.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG58202; AAG58202; Z4421
BAB37374; BAB37374; BAB37374
GeneIDi916221
KEGGiece:Z4421
ecs:ECs3951
PATRICifig|386585.9.peg.4122

Entry informationi

Entry nameiMUG_ECO57
AccessioniPrimary (citable) accession number: Q8XAN4
Secondary accession number(s): Q7AAP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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