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Protein

3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase

Gene

hcaB

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively.UniRule annotation

Catalytic activityi

3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ = 3-(2,3-dihydroxyphenyl)propanoate + NADH.UniRule annotation
(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD+ = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH.UniRule annotation

Pathwayi: 3-phenylpropanoate degradation

This protein is involved in the pathway 3-phenylpropanoate degradation, which is part of Aromatic compound metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 3-phenylpropanoate degradation and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143SubstrateUniRule annotation1
Active sitei156Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 34NADUniRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00714

Names & Taxonomyi

Protein namesi
Recommended name:
3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenaseUniRule annotation (EC:1.3.1.87UniRule annotation)
Alternative name(s):
2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenaseUniRule annotation
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenaseUniRule annotation
CI-dihydrodiol dehydrogenaseUniRule annotation
Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenaseUniRule annotation
Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenaseUniRule annotation
PP-dihydrodiol dehydrogenaseUniRule annotation
Gene namesi
Name:hcaBUniRule annotation
Ordered Locus Names:Z3813, ECs3407
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003337611 – 2703-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenaseAdd BLAST270

Interactioni

Protein-protein interaction databases

STRINGi155864.Z3813

Structurei

3D structure databases

ProteinModelPortaliQ8XA72
SMRiQ8XA72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108QJ2 Bacteria
ENOG410XQCB LUCA
KOiK05711
OMAiPNAGIWD

Family and domain databases

HAMAPiMF_01647 HcaB, 1 hit
InterProiView protein in InterPro
IPR023643 Dihydrodiol_DH_HcaB
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XA72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLHNESIF ITGGGSGLGL ALVERFIEEG AQVATLELSA AKVASLRQRF
60 70 80 90 100
GEHILAVEGN VTCYADYQRA VDQILTRSGK LDCFIGNAGI WDHNASLVNT
110 120 130 140 150
PAETLETGFH ELFNVNVLGY LLGAKACAPA LIAGEGSMIF TLSNAAWYPG
160 170 180 190 200
GGGPLYTASK HAATGLIRQL AYELAPKVRV NGVGPCGMAS DLRGPQALGQ
210 220 230 240 250
SETSIMQSLT PEKIAAILPL QFFPQPADFT GPYVMLASRR NNRALSGVMI
260 270
NADAGLAIRG IRHVAAGLDL
Length:270
Mass (Da):28,440
Last modified:March 1, 2002 - v1
Checksum:i6BFE56F10442C2A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG57654.1
BA000007 Genomic DNA Translation: BAB36830.1
PIRiB85899
G91054
RefSeqiNP_311434.1, NC_002695.1
WP_001281372.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG57654; AAG57654; Z3813
BAB36830; BAB36830; BAB36830
GeneIDi914919
KEGGiece:Z3813
ecs:ECs3407
PATRICifig|386585.9.peg.3559

Similar proteinsi

Entry informationi

Entry nameiHCAB_ECO57
AccessioniPrimary (citable) accession number: Q8XA72
Secondary accession number(s): Q7ABL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health