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Protein

Crotonobetaine/carnitine--CoA ligase

Gene

caiC

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.UniRule annotation

Catalytic activityi

ATP + 4-(trimethylamino)butanoate + CoA = AMP + diphosphate + gamma-butyrobetainyl-CoA.UniRule annotation
ATP + crotonobetaine + CoA = AMP + diphosphate + crotonobetainyl-CoA.UniRule annotation
ATP + L-carnitine + CoA = AMP + diphosphate + L-carnitinyl-CoA.UniRule annotation

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase

Enzyme and pathway databases

UniPathwayiUPA00117.

Names & Taxonomyi

Protein namesi
Recommended name:
Crotonobetaine/carnitine--CoA ligaseUniRule annotation (EC:6.2.1.48UniRule annotation)
Gene namesi
Name:caiCUniRule annotation
Ordered Locus Names:Z0043, ECs0040
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001930671 – 517Crotonobetaine/carnitine--CoA ligaseAdd BLAST517

Proteomic databases

PRIDEiQ8XA34.

Interactioni

Protein-protein interaction databases

STRINGi155864.Z0043.

Structurei

3D structure databases

ProteinModelPortaliQ8XA34.
SMRiQ8XA34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEY. Bacteria.
COG0318. LUCA.
HOGENOMiHOG000230001.
KOiK02182.
OMAiWLMQRAF.

Family and domain databases

HAMAPiMF_01524. CaiC. 1 hit.
InterProiView protein in InterPro
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023456. CaiC.
PfamiView protein in Pfam
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PROSITEiView protein in PROSITE
PS00455. AMP_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XA34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIIGGQHLR QMWDDLADVY GHKTALICES SGGVVNRYSY LELNQEINRT
60 70 80 90 100
ANLFYTLGIR KGDKVALHLD NCPEFIFCWF GLAKIGAIMV PINARLLREE
110 120 130 140 150
SAWILQNSQA CLLVTSAQFY PMYQQIQQED ATQLRHICLT DVALPADDGV
160 170 180 190 200
SSFTQLKNQQ PATLCYAPPL STDDTAEILF TSGTTSRPKG VVITHYNLRF
210 220 230 240 250
AGYYSAWQCA LRDDDVYLTV MPAFHIDCQC TAAMAAFSAG ATFVLVEKYS
260 270 280 290 300
ARAFWGQVQK YRATITECIP MMIRTLMVQP PSANDRQHRL REVMFYLNLS
310 320 330 340 350
EQEKDTFCER FGVRLLTSYG MTETIVGIIG DRPGDKRRWP SIGRAGFCYD
360 370 380 390 400
AEIRDDHNRP LPAGEIGEIC IKGVPGKTIF KEYFLNPKAT AKVLEADGWL
410 420 430 440 450
HTGDTGYRDE EGFFYFIDRR CNMIKRGGEN VSCVELENII ATHPKIQDIV
460 470 480 490 500
VVGIKDSIRD EAIKAFVVLN EGETLSEEEF FRFCEQNMAK FKVPSYLEIR
510
KDLPRNCSGK IIRKNLK
Length:517
Mass (Da):58,614
Last modified:August 21, 2007 - v2
Checksum:i0B0778C5D1A40651
GO

Sequence cautioni

The sequence AAG54340 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB33463 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG54340.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB33463.1. Different initiation.
PIRiH85484.
H90633.
RefSeqiNP_308067.2. NC_002695.1.
WP_001301863.1. NZ_NOKN01000002.1.

Genome annotation databases

EnsemblBacteriaiAAG54340; AAG54340; Z0043.
BAB33463; BAB33463; BAB33463.
GeneIDi913437.
KEGGiece:Z0043.
ecs:ECs0040.
PATRICifig|386585.9.peg.137.

Similar proteinsi

Entry informationi

Entry nameiCAIC_ECO57
AccessioniPrimary (citable) accession number: Q8XA34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome