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Protein

Multidrug resistance protein MdtG

Gene

mdtG

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Confers resistance to fosfomycin and deoxycholate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtGUniRule annotation
Gene namesi
Name:mdtGUniRule annotation
Ordered Locus Names:Z1688, ECs1431
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalUniRule annotationAdd BLAST21
Transmembranei58 – 78HelicalUniRule annotationAdd BLAST21
Transmembranei92 – 112HelicalUniRule annotationAdd BLAST21
Transmembranei115 – 135HelicalUniRule annotationAdd BLAST21
Transmembranei146 – 166HelicalUniRule annotationAdd BLAST21
Transmembranei173 – 193HelicalUniRule annotationAdd BLAST21
Transmembranei224 – 244HelicalUniRule annotationAdd BLAST21
Transmembranei256 – 276HelicalUniRule annotationAdd BLAST21
Transmembranei290 – 310HelicalUniRule annotationAdd BLAST21
Transmembranei319 – 339HelicalUniRule annotationAdd BLAST21
Transmembranei378 – 398HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001733361 – 408Multidrug resistance protein MdtGAdd BLAST408

Interactioni

Protein-protein interaction databases

STRINGi155864.Z1688.

Structurei

3D structure databases

ProteinModelPortaliQ8X9I3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000066093.
KOiK08161.
OMAiSYGFRTV.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01528. MFS_MdtG. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023692. Mutidrug-R_MdtG.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X9I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPCENDTPI NWKRNLIVAW LGCFLTGAAF SLVMPFLPLY VEQLGVTGHS
60 70 80 90 100
ALNMWSGIVF SITFLFSAIA SPFWGGLADR KGRKLMLLRS ALGMGIVMVL
110 120 130 140 150
MGLAQNIWQF LILRALLGLL GGFVPNANAL IATQVPRNKS GWALGTLSTG
160 170 180 190 200
GVSGALLGPM AGGLLADSYG LRPVFFITAS VLILCFFVTL FCIREKFQPV
210 220 230 240 250
SKKEMLHMRE VVTSLKNPKL VLSLFVTTLI IQVATGSIAP ILTLYVRELA
260 270 280 290 300
GNVSNVAFIS GMIASVPGVA ALLSAPRLGK LGDRIGPEKI LITALIFSVL
310 320 330 340 350
LLIPMSYVQT PLQLGILRFL LGAADGALLP AVQTLLVYNS SNQIAGRIFS
360 370 380 390 400
YNQSFRDIGN VTGPLMGAAI SANYGFRAVF LVTAGVVLFN AVYSWNSLRR

RRIPQVSN
Length:408
Mass (Da):43,867
Last modified:March 1, 2005 - v2
Checksum:iC07B719D54A28D27
GO

Sequence cautioni

The sequence AAG55799 differs from that shown. Reason: Erroneous termination at position 37. Translated as Leu.Curated
The sequence BAB34854 differs from that shown. Reason: Erroneous termination at position 37. Translated as Leu.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55799.1. Sequence problems.
BA000007 Genomic DNA. Translation: BAB34854.1. Sequence problems.
PIRiC85667.
G90807.

Genome annotation databases

EnsemblBacteriaiAAG55799; AAG55799; Z1688.
BAB34854; BAB34854; BAB34854.
KEGGiece:Z1688.
PATRICi18352101. VBIEscCol44059_1277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55799.1. Sequence problems.
BA000007 Genomic DNA. Translation: BAB34854.1. Sequence problems.
PIRiC85667.
G90807.

3D structure databases

ProteinModelPortaliQ8X9I3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z1688.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG55799; AAG55799; Z1688.
BAB34854; BAB34854; BAB34854.
KEGGiece:Z1688.
PATRICi18352101. VBIEscCol44059_1277.

Phylogenomic databases

HOGENOMiHOG000066093.
KOiK08161.
OMAiSYGFRTV.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01528. MFS_MdtG. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023692. Mutidrug-R_MdtG.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDTG_ECO57
AccessioniPrimary (citable) accession number: Q8X9I3
Secondary accession number(s): Q7AFA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.