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Protein

Multidrug resistance protein MdtG

Gene

mdtG

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Confers resistance to fosfomycin and deoxycholate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntibiotic resistance, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtGUniRule annotation
Gene namesi
Name:mdtGUniRule annotation
Ordered Locus Names:Z1688, ECs1431
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalUniRule annotationAdd BLAST21
Transmembranei58 – 78HelicalUniRule annotationAdd BLAST21
Transmembranei92 – 112HelicalUniRule annotationAdd BLAST21
Transmembranei115 – 135HelicalUniRule annotationAdd BLAST21
Transmembranei146 – 166HelicalUniRule annotationAdd BLAST21
Transmembranei173 – 193HelicalUniRule annotationAdd BLAST21
Transmembranei224 – 244HelicalUniRule annotationAdd BLAST21
Transmembranei256 – 276HelicalUniRule annotationAdd BLAST21
Transmembranei290 – 310HelicalUniRule annotationAdd BLAST21
Transmembranei319 – 339HelicalUniRule annotationAdd BLAST21
Transmembranei378 – 398HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001733361 – 408Multidrug resistance protein MdtGAdd BLAST408

Interactioni

Protein-protein interaction databases

STRINGi155864.Z1688

Structurei

3D structure databases

ProteinModelPortaliQ8X9I3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000066093
KOiK08161
OMAiVIRHNVP

Family and domain databases

CDDicd06174 MFS, 1 hit
HAMAPiMF_01528 MFS_MdtG, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR023692 Mutidrug-R_MdtG
IPR001958 Tet-R_TetA/multi-R_MdtG
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PRINTSiPR01035 TCRTETA
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8X9I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPCENDTPI NWKRNLIVAW LGCFLTGAAF SLVMPFLPLY VEQLGVTGHS
60 70 80 90 100
ALNMWSGIVF SITFLFSAIA SPFWGGLADR KGRKLMLLRS ALGMGIVMVL
110 120 130 140 150
MGLAQNIWQF LILRALLGLL GGFVPNANAL IATQVPRNKS GWALGTLSTG
160 170 180 190 200
GVSGALLGPM AGGLLADSYG LRPVFFITAS VLILCFFVTL FCIREKFQPV
210 220 230 240 250
SKKEMLHMRE VVTSLKNPKL VLSLFVTTLI IQVATGSIAP ILTLYVRELA
260 270 280 290 300
GNVSNVAFIS GMIASVPGVA ALLSAPRLGK LGDRIGPEKI LITALIFSVL
310 320 330 340 350
LLIPMSYVQT PLQLGILRFL LGAADGALLP AVQTLLVYNS SNQIAGRIFS
360 370 380 390 400
YNQSFRDIGN VTGPLMGAAI SANYGFRAVF LVTAGVVLFN AVYSWNSLRR

RRIPQVSN
Length:408
Mass (Da):43,867
Last modified:March 1, 2005 - v2
Checksum:iC07B719D54A28D27
GO

Sequence cautioni

The sequence AAG55799 differs from that shown. Reason: Erroneous termination at position 37. Translated as Leu.Curated
The sequence BAB34854 differs from that shown. Reason: Erroneous termination at position 37. Translated as Leu.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55799.1 Sequence problems.
BA000007 Genomic DNA Translation: BAB34854.1 Sequence problems.
PIRiC85667
G90807

Genome annotation databases

EnsemblBacteriaiAAG55799; AAG55799; Z1688
BAB34854; BAB34854; BAB34854
KEGGiece:Z1688

Similar proteinsi

Entry informationi

Entry nameiMDTG_ECO57
AccessioniPrimary (citable) accession number: Q8X9I3
Secondary accession number(s): Q7AFA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: April 25, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health