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Protein

Putative sialic acid transporter

Gene

nanT

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be a sugar-cation symporter involved in sialic acid uptake.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4060-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sialic acid transporter
Alternative name(s):
Sialic acid permease
Gene namesi
Name:nanT
Ordered Locus Names:Z4582, ECs4097
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121CytoplasmicSequence analysisAdd
BLAST
Transmembranei22 – 4221HelicalSequence analysisAdd
BLAST
Topological domaini43 – 5715PeriplasmicSequence analysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence analysisAdd
BLAST
Topological domaini79 – 9113CytoplasmicSequence analysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST
Topological domaini113 – 14735PeriplasmicSequence analysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Topological domaini169 – 1691CytoplasmicSequence analysis
Transmembranei170 – 19021HelicalSequence analysisAdd
BLAST
Topological domaini191 – 22333PeriplasmicSequence analysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence analysisAdd
BLAST
Topological domaini245 – 2462CytoplasmicSequence analysis
Transmembranei247 – 26721HelicalSequence analysisAdd
BLAST
Topological domaini268 – 27710PeriplasmicSequence analysis
Transmembranei278 – 29821HelicalSequence analysisAdd
BLAST
Topological domaini299 – 31214CytoplasmicSequence analysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence analysisAdd
BLAST
Topological domaini334 – 35421PeriplasmicSequence analysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence analysisAdd
BLAST
Topological domaini376 – 40530CytoplasmicSequence analysisAdd
BLAST
Transmembranei406 – 42621HelicalSequence analysisAdd
BLAST
Topological domaini427 – 4304PeriplasmicSequence analysis
Transmembranei431 – 45121HelicalSequence analysisAdd
BLAST
Topological domaini452 – 49645CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Putative sialic acid transporterPRO_0000050312Add
BLAST

Expressioni

Inductioni

By N-acetylneuraminate.By similarity

Interactioni

Protein-protein interaction databases

STRINGi155864.Z4582.

Structurei

3D structure databases

ProteinModelPortaliQ8X9G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105JHE. Bacteria.
ENOG410XSSD. LUCA.
HOGENOMiHOG000074791.
KOiK03290.
OMAiIGYLLDG.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01238. MFS_NanT. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004742. SA_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00891. 2A0112. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X9G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTTQNIPW YRHLNRAQWR AFSAAWLGYL LDGFDFVLIA LVLTEVQGEF
60 70 80 90 100
GLTTVQAASL ISAAFISRWF GGLMLGAMGD RYGRRLAMVT SIVLFSAGTL
110 120 130 140 150
ACGFAPGYIT MFIARLVIGM GMAGEYGSSA TYVIESWPKH LRNKASGFLI
160 170 180 190 200
SGFSVGAVVA AQVYSLVVPV WGWRALFFIG ILPIIFALWL RKNIPEAEDW
210 220 230 240 250
KEKHAGKAPV RTMVDILYRG EHRIANIVMT LAAATALWFC FAGNLQNAAI
260 270 280 290 300
VAVLGLLCTA IFISFMVQST GKRWPTGVML MVVVLFAFLY SWPIQALLPT
310 320 330 340 350
YLKTDLAYNP HTVANVLFFS GFGAAVGCCV GGFLGDWLGT RKAYVCSLLA
360 370 380 390 400
SQLLIIPVFA IGGANVWVLG LLLFFQQMLG QGIAGILPKL IGGYFDTDQR
410 420 430 440 450
AAGLGFTYNV GALGGALAPI IGALIAQRLD LGTALASLSF SLTFVVILLI
460 470 480 490
GLDMPSRVQR WLRPEALRTH DAIDGKPFSG AVPFGSAKND LVKTKS
Length:496
Mass (Da):53,611
Last modified:May 30, 2003 - v2
Checksum:i88121FE40ACF1211
GO

Sequence cautioni

The sequence AAG58352 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB37520 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG58352.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB37520.1. Different initiation.
PIRiA91141.
D85986.
RefSeqiNP_312124.2. NC_002695.1.
WP_000108469.1. NZ_LPWC01000011.1.

Genome annotation databases

EnsemblBacteriaiAAG58352; AAG58352; Z4582.
BAB37520; BAB37520; BAB37520.
GeneIDi916054.
KEGGiece:Z4582.
ecs:ECs4097.
PATRICi18357716. VBIEscCol44059_4032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG58352.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB37520.1. Different initiation.
PIRiA91141.
D85986.
RefSeqiNP_312124.2. NC_002695.1.
WP_000108469.1. NZ_LPWC01000011.1.

3D structure databases

ProteinModelPortaliQ8X9G8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z4582.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG58352; AAG58352; Z4582.
BAB37520; BAB37520; BAB37520.
GeneIDi916054.
KEGGiece:Z4582.
ecs:ECs4097.
PATRICi18357716. VBIEscCol44059_4032.

Phylogenomic databases

eggNOGiENOG4105JHE. Bacteria.
ENOG410XSSD. LUCA.
HOGENOMiHOG000074791.
KOiK03290.
OMAiIGYLLDG.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4060-MONOMER.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01238. MFS_NanT. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004742. SA_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00891. 2A0112. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNANT_ECO57
AccessioniPrimary (citable) accession number: Q8X9G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: September 7, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.