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Protein

Sialic acid transporter NanT

Gene

nanT

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the proton-dependent transport of sialic acid.UniRule annotation

GO - Molecular functioni

Keywordsi

Biological processSugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid transporter NanTUniRule annotation
Alternative name(s):
Sialic acid permeaseUniRule annotation
Sialic acid/H(+) symporterUniRule annotation
Gene namesi
Name:nanTUniRule annotation
Ordered Locus Names:Z4582, ECs4097
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalUniRule annotationAdd BLAST21
Transmembranei58 – 78HelicalUniRule annotationAdd BLAST21
Transmembranei92 – 112HelicalUniRule annotationAdd BLAST21
Transmembranei116 – 136HelicalUniRule annotationAdd BLAST21
Transmembranei148 – 168HelicalUniRule annotationAdd BLAST21
Transmembranei170 – 190HelicalUniRule annotationAdd BLAST21
Transmembranei224 – 244HelicalUniRule annotationAdd BLAST21
Transmembranei247 – 267HelicalUniRule annotationAdd BLAST21
Transmembranei278 – 298HelicalUniRule annotationAdd BLAST21
Transmembranei313 – 333HelicalUniRule annotationAdd BLAST21
Transmembranei353 – 375HelicalUniRule annotationAdd BLAST23
Transmembranei406 – 426HelicalUniRule annotationAdd BLAST21
Transmembranei431 – 451HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503121 – 496Sialic acid transporter NanTAdd BLAST496

Interactioni

Protein-protein interaction databases

STRINGi155864.Z4582.

Structurei

3D structure databases

ProteinModelPortaliQ8X9G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105JHE. Bacteria.
ENOG410XSSD. LUCA.
HOGENOMiHOG000074791.
KOiK03290.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01238. MFS_NanT. 1 hit.
InterProiView protein in InterPro
IPR011701. MFS.
IPR020846. MFS_dom.
IPR004742. SA_transporter.
PfamiView protein in Pfam
PF07690. MFS_1. 1 hit.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00891. 2A0112. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8X9G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTTQNIPW YRHLNRAQWR AFSAAWLGYL LDGFDFVLIA LVLTEVQGEF
60 70 80 90 100
GLTTVQAASL ISAAFISRWF GGLMLGAMGD RYGRRLAMVT SIVLFSAGTL
110 120 130 140 150
ACGFAPGYIT MFIARLVIGM GMAGEYGSSA TYVIESWPKH LRNKASGFLI
160 170 180 190 200
SGFSVGAVVA AQVYSLVVPV WGWRALFFIG ILPIIFALWL RKNIPEAEDW
210 220 230 240 250
KEKHAGKAPV RTMVDILYRG EHRIANIVMT LAAATALWFC FAGNLQNAAI
260 270 280 290 300
VAVLGLLCTA IFISFMVQST GKRWPTGVML MVVVLFAFLY SWPIQALLPT
310 320 330 340 350
YLKTDLAYNP HTVANVLFFS GFGAAVGCCV GGFLGDWLGT RKAYVCSLLA
360 370 380 390 400
SQLLIIPVFA IGGANVWVLG LLLFFQQMLG QGIAGILPKL IGGYFDTDQR
410 420 430 440 450
AAGLGFTYNV GALGGALAPI IGALIAQRLD LGTALASLSF SLTFVVILLI
460 470 480 490
GLDMPSRVQR WLRPEALRTH DAIDGKPFSG AVPFGSAKND LVKTKS
Length:496
Mass (Da):53,611
Last modified:May 30, 2003 - v2
Checksum:i88121FE40ACF1211
GO

Sequence cautioni

The sequence AAG58352 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB37520 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG58352.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB37520.1. Different initiation.
PIRiA91141.
D85986.
RefSeqiNP_312124.2. NC_002695.1.
WP_000108469.1. NZ_MWVM01000015.1.

Genome annotation databases

EnsemblBacteriaiAAG58352; AAG58352; Z4582.
BAB37520; BAB37520; BAB37520.
GeneIDi916054.
KEGGiece:Z4582.
ecs:ECs4097.
PATRICifig|386585.9.peg.4277.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNANT_ECO57
AccessioniPrimary (citable) accession number: Q8X9G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: July 5, 2017
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families