Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8X902 (LUXS_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
S-ribosylhomocysteine lyase
EC=4.4.1.21
Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
Gene names
Name:luxS
Ordered Locus Names:Z3988, ECs3549
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length171 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. HAMAP MF_00091

Catalytic activity

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. HAMAP MF_00091

Cofactor

Binds 1 iron ion per subunit By similarity. HAMAP MF_00091

Subunit structure

Homodimer By similarity. HAMAP MF_00091

Sequence similarities

Belongs to the LuxS family.

Ontologies

Keywords
   Biological processAutoinducer synthesis
Quorum sensing
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processquorum sensing

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionS-ribosylhomocysteine lyase activity

Inferred from electronic annotation. Source: EC

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 171170S-ribosylhomocysteine lyase HAMAP MF_00091
PRO_0000172222

Sites

Metal binding541Iron By similarity
Metal binding581Iron By similarity
Metal binding1281Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8X902 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 1A9457F19962B11A

FASTA17119,444
        10         20         30         40         50         60 
MPLLDSFTVD HTRMEAPAVR VAKTMNTPHG DAITVFDLRF CVPNKEVMPE RGIHTLEHLF 

        70         80         90        100        110        120 
AGFMRNHLNG NGVEIIDISP MGCRTGFYMS LIGTPDEQRV ADVWKAAMED VLKVQDQNQI 

       130        140        150        160        170 
PELNVYQCGT YQMHSLQEAQ DIARSILERD VRINSNEELA LPKEKLQELH I

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005174 Genomic DNA. Translation: AAG57796.1.
BA000007 Genomic DNA. Translation: BAB36972.1.
PIRE91072.
H85916.
RefSeqNP_289238.1. NC_002655.2.
NP_311576.1. NC_002695.1.

3D structure databases

ProteinModelPortalQ8X902.
SMRQ8X902. Positions 3-161.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000028077; EBESCP00000026970; EBESCG00000027129.
EBESCT00000056481; EBESCP00000054309; EBESCG00000055529.
GeneID914734.
960942.
GenomeReviewsGene locus Z3988 in contig AE005174_GR.
Gene locus ECs3549 in contig BA000007_GR.
KEGGece:Z3988.
ecs:ECs3549.
PATRIC18356544. VBIEscCol44059_3460.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000010742.
HOGENOMHBG347473.
OMAPHGDTIT.
ProtClustDBPRK02260.

Enzyme and pathway databases

BioCycECOL83334:ECS3549-MONOMER.
BRENDA4.4.1.21. 2026.

Family and domain databases

HAMAPMF_00091. LuxS.
[Tree]
InterProIPR011249. Metalloenz_metal-bd.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
Gene3DG3DSA:3.30.1360.80. S-ribosylhomocysteinase. 1 hit.
KOK07173.
PfamPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFPIRSF006160. AI2. 1 hit.
PRINTSPR01487. LUXSPROTEIN.
ProDomPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF63411. Metalloenz_metal-bd. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLUXS_ECO57
AccessionPrimary (citable) accession number: Q8X902
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 63 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents