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Protein

Putative carboxymethylenebutenolidase

Gene

ysgA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

4-carboxymethylenebut-2-en-4-olide + H2O = 4-oxohex-2-enedioate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei147 – 1471By similarity
Active sitei204 – 2041By similarity
Active sitei236 – 2361By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4742-MONOMER.

Protein family/group databases

ESTHERiecoli-dlhh. Dienelactone_hydrolase.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative carboxymethylenebutenolidase (EC:3.1.1.45)
Alternative name(s):
Dienelactone hydrolase
Short name:
DLH
Gene namesi
Name:ysgA
Ordered Locus Names:Z5352, ECs4760
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Putative carboxymethylenebutenolidasePRO_0000161579Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5352.

Structurei

3D structure databases

ProteinModelPortaliQ8X8L4.
SMRiQ8X8L4. Positions 26-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dienelactone hydrolase family.Curated

Phylogenomic databases

eggNOGiENOG4105CDZ. Bacteria.
COG0412. LUCA.
HOGENOMiHOG000157123.
KOiK01061.
OMAiCWGGRIS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002925. Dienelactn_hydro.
[Graphical view]
PfamiPF01738. DLH. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8X8L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTQQSGFA PAASPLASTI VQTPDDAIVA GFTSIPSQGD NMPAYHARPK
60 70 80 90 100
QSDGPLPVVI VVQEIFGVHE HIRDICRRLA LEGYLAIAPE LYFREGDPND
110 120 130 140 150
FADIPTLLSG LVAKVPDSQV LADLDHVASW ASRNGGDVHR LMITGFCWGG
160 170 180 190 200
RITWLYAAHN PQLKAAVAWY GKLTGDKSLN SPKQPVDIAT DLNAPVLGLY
210 220 230 240 250
GGLDNSIPQE SVETMRQALR AANAKAEIIV YPDAGHAFNA DYRPSYHAAS
260 270
AEDGWQRMLE WFKQYGGKKS L
Length:271
Mass (Da):29,396
Last modified:February 21, 2002 - v1
Checksum:iA2FCEACBDC8F91E5
GO

Sequence cautioni

The sequence AAG59026 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB38183 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59026.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB38183.1. Different initiation.
PIRiF86070.
H91223.
RefSeqiNP_312787.1. NC_002695.1.
WP_001301462.1. NZ_LPWC01000188.1.

Genome annotation databases

EnsemblBacteriaiAAG59026; AAG59026; Z5352.
BAB38183; BAB38183; BAB38183.
GeneIDi915144.
KEGGiece:Z5352.
ecs:ECs4760.
PATRICi18359145. VBIEscCol44059_4727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59026.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB38183.1. Different initiation.
PIRiF86070.
H91223.
RefSeqiNP_312787.1. NC_002695.1.
WP_001301462.1. NZ_LPWC01000188.1.

3D structure databases

ProteinModelPortaliQ8X8L4.
SMRiQ8X8L4. Positions 26-265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z5352.

Protein family/group databases

ESTHERiecoli-dlhh. Dienelactone_hydrolase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG59026; AAG59026; Z5352.
BAB38183; BAB38183; BAB38183.
GeneIDi915144.
KEGGiece:Z5352.
ecs:ECs4760.
PATRICi18359145. VBIEscCol44059_4727.

Phylogenomic databases

eggNOGiENOG4105CDZ. Bacteria.
COG0412. LUCA.
HOGENOMiHOG000157123.
KOiK01061.
OMAiCWGGRIS.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4742-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002925. Dienelactn_hydro.
[Graphical view]
PfamiPF01738. DLH. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDLHH_ECO57
AccessioniPrimary (citable) accession number: Q8X8L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.