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Q8X8I7

- FABD_ECO57

UniProt

Q8X8I7 - FABD_ECO57

Protein

Malonyl CoA-acyl carrier protein transacylase

Gene

fabD

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei92 – 921By similarity
    Active sitei201 – 2011By similarity

    GO - Molecular functioni

    1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-1456-MONOMER.
    ECOO157:FABD-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
    Short name:
    MCT
    Gene namesi
    Name:fabD
    Ordered Locus Names:Z1731, ECs1470
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 309308Malonyl CoA-acyl carrier protein transacylasePRO_0000194214Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi155864.Z1731.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8X8I7.
    SMRiQ8X8I7. Positions 3-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FabD family.Curated

    Phylogenomic databases

    eggNOGiCOG0331.
    HOGENOMiHOG000036503.
    KOiK00645.
    OMAiIWRVWQE.
    OrthoDBiEOG6W19KW.

    Family and domain databases

    Gene3Di3.40.366.10. 2 hits.
    InterProiIPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR024925. Malonyl_CoA-ACP_transAc.
    IPR004410. Malonyl_CoA-ACP_transAc_FabD.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000446. Mct. 1 hit.
    SUPFAMiSSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    TIGRFAMsiTIGR00128. fabD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8X8I7-1 [UniParc]FASTAAdd to Basket

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    MTQFAFVFPG QGSQTVGMLA DMAASYPIVE ETFAEASAAL GYDLWALTQQ    50
    GPAEELNKTW QTQPALLTAS VALYRVWQQH GGKAPAMMAG HSLGEYSALV 100
    CAGVIDFADA VRLVEMRGKF MQEAVPEGTG AMAAIIGLDD ASIGKACEEA 150
    AEGQVVSPVN FNSPGQVVIA GHKEAVERAG AACKAAGAKR ALPLPVSVPS 200
    HCALMKPAAD KLAVELAKIT FNAPTVPVVN NVDVKCETNG DAIRDALVRQ 250
    LYNPVQWTKS VEYMAAQGVE HLYEVGPGKV LTGLTKRIVD TLTASALNEP 300
    SAMAAALEL 309
    Length:309
    Mass (Da):32,412
    Last modified:January 23, 2007 - v3
    Checksum:i3DCB41120D526F71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG55838.1.
    BA000007 Genomic DNA. Translation: BAB34893.1.
    PIRiB85672.
    F90812.
    RefSeqiNP_287226.1. NC_002655.2.
    NP_309497.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG55838; AAG55838; Z1731.
    BAB34893; BAB34893; BAB34893.
    GeneIDi913863.
    959436.
    KEGGiece:Z1731.
    ecs:ECs1470.
    PATRICi18352177. VBIEscCol44059_1315.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG55838.1 .
    BA000007 Genomic DNA. Translation: BAB34893.1 .
    PIRi B85672.
    F90812.
    RefSeqi NP_287226.1. NC_002655.2.
    NP_309497.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali Q8X8I7.
    SMRi Q8X8I7. Positions 3-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z1731.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG55838 ; AAG55838 ; Z1731 .
    BAB34893 ; BAB34893 ; BAB34893 .
    GeneIDi 913863.
    959436.
    KEGGi ece:Z1731.
    ecs:ECs1470.
    PATRICi 18352177. VBIEscCol44059_1315.

    Phylogenomic databases

    eggNOGi COG0331.
    HOGENOMi HOG000036503.
    KOi K00645.
    OMAi IWRVWQE.
    OrthoDBi EOG6W19KW.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci ECOL386585:GJFA-1456-MONOMER.
    ECOO157:FABD-MONOMER.

    Family and domain databases

    Gene3Di 3.40.366.10. 2 hits.
    InterProi IPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR024925. Malonyl_CoA-ACP_transAc.
    IPR004410. Malonyl_CoA-ACP_transAc_FabD.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000446. Mct. 1 hit.
    SUPFAMi SSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    TIGRFAMsi TIGR00128. fabD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiFABD_ECO57
    AccessioniPrimary (citable) accession number: Q8X8I7
    Secondary accession number(s): Q7AF87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3