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Q8X8I7 (FABD_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malonyl CoA-acyl carrier protein transacylase
Short name=MCT
EC=2.3.1.39
Gene names
Name:fabD
Ordered Locus Names:Z1731, ECs1470
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Sequence similarities

Belongs to the fabD family.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Lipid synthesis
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function[acyl-carrier-protein] S-malonyltransferase activity

Inferred from electronic annotation. Source: EC

binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 309308Malonyl CoA-acyl carrier protein transacylase
PRO_0000194214

Sites

Active site921 By similarity
Active site2011 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8X8I7 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 3DCB41120D526F71

FASTA30932,412
        10         20         30         40         50         60 
MTQFAFVFPG QGSQTVGMLA DMAASYPIVE ETFAEASAAL GYDLWALTQQ GPAEELNKTW 

        70         80         90        100        110        120 
QTQPALLTAS VALYRVWQQH GGKAPAMMAG HSLGEYSALV CAGVIDFADA VRLVEMRGKF 

       130        140        150        160        170        180 
MQEAVPEGTG AMAAIIGLDD ASIGKACEEA AEGQVVSPVN FNSPGQVVIA GHKEAVERAG 

       190        200        210        220        230        240 
AACKAAGAKR ALPLPVSVPS HCALMKPAAD KLAVELAKIT FNAPTVPVVN NVDVKCETNG 

       250        260        270        280        290        300 
DAIRDALVRQ LYNPVQWTKS VEYMAAQGVE HLYEVGPGKV LTGLTKRIVD TLTASALNEP 


SAMAAALEL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005174 Genomic DNA. Translation: AAG55838.1.
BA000007 Genomic DNA. Translation: BAB34893.1.
PIRB85672.
F90812.
RefSeqNP_287226.1. NC_002655.2.
NP_309497.1. NC_002695.1.

3D structure databases

ProteinModelPortalQ8X8I7.
SMRQ8X8I7. Positions 3-307.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000026685; EBESCP00000025578; EBESCG00000025738.
EBESCT00000056041; EBESCP00000053869; EBESCG00000055089.
GeneID913863.
959436.
GenomeReviewsGene locus Z1731 in contig AE005174_GR.
Gene locus ECs1470 in contig BA000007_GR.
KEGGece:Z1731.
ecs:ECs1470.
PATRIC18352177. VBIEscCol44059_1315.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000008801.
HOGENOMHBG687898.
OMANAMQAAV.
ProtClustDBCLSK879951.

Enzyme and pathway databases

BioCycECOL83334:ECS1470-MONOMER.

Family and domain databases

InterProIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
Gene3DG3DSA:3.40.366.10. Ac_transferase_reg. 2 hits.
KOK00645.
PfamPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFPIRSF000446. Mct. 1 hit.
SUPFAMSSF52151. Acyl_Trfase/lysoPlipase. 1 hit.
SSF55048. Malonyl_transacylase_ACP-bd. 1 hit.
TIGRFAMsTIGR00128. FabD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABD_ECO57
AccessionPrimary (citable) accession number: Q8X8I7
Secondary accession number(s): Q7AF87
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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