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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi157ZincUniRule annotation1
Metal bindingi177ZincUniRule annotation1
Metal bindingi179ZincUniRule annotation1
Metal bindingi184ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi4 – 11ATPUniRule annotation8
Nucleotide bindingi133 – 140ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCarbohydrate metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00544

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
Alternative name(s):
GlcNAc kinaseUniRule annotation
Gene namesi
Name:nagKUniRule annotation
Ordered Locus Names:Z1760, ECs1497
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002701011 – 303N-acetyl-D-glucosamine kinaseAdd BLAST303

Proteomic databases

PRIDEiQ8X8E1

Interactioni

Protein-protein interaction databases

STRINGi155864.Z1760

Structurei

3D structure databases

ProteinModelPortaliQ8X8E1
SMRiQ8X8E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EZX Bacteria
COG1940 LUCA
HOGENOMiHOG000150087
KOiK00884
OMAiLQLNYHA

Family and domain databases

HAMAPiMF_01271 GlcNAc_kinase, 1 hit
InterProiView protein in InterPro
IPR023505 N-acetyl-D-glucosamine_kinase
IPR000600 ROK
PANTHERiPTHR18964 PTHR18964, 1 hit
PfamiView protein in Pfam
PF00480 ROK, 1 hit
PROSITEiView protein in PROSITE
PS01125 ROK, 1 hit

Sequencei

Sequence statusi: Complete.

Q8X8E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYGFDIGGT KIALGVFDSG RQLQWEKRVP TPRDSYDAFL DAVCELVAEA
60 70 80 90 100
DQRFGCKGSV GIGIPGMPET EDGTLYAANV PAASGKPLRA DLSARLDRDV
110 120 130 140 150
RLDNDANCFA LSEAWDDEFT QYPLVMGLIL GTGVGGGLIF NGKPITGKSY
160 170 180 190 200
ITGEFGHMRL PVDALTMMGL DFPLRRCGCG QHGCIENYLS GRGFAWLYQH
210 220 230 240 250
YYHQPLPAPE IIALYDQGDE QARAHVERYL DLLAVCLGNI LTIVDPDLVV
260 270 280 290 300
IGGGLSNFPA ITTQLADRLP RHLLPVARVP RIERARHGDA GGMRGAAFLH

LTD
Length:303
Mass (Da):33,012
Last modified:March 1, 2002 - v1
Checksum:iA9FD57923F38E10D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55865.1
BA000007 Genomic DNA Translation: BAB34920.1
PIRiA99816
E85675
RefSeqiNP_309524.1, NC_002695.1
WP_000291263.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG55865; AAG55865; Z1760
BAB34920; BAB34920; BAB34920
GeneIDi912695
KEGGiece:Z1760
ecs:ECs1497
PATRICifig|386585.9.peg.1599

Similar proteinsi

Entry informationi

Entry nameiNAGK_ECO57
AccessioniPrimary (citable) accession number: Q8X8E1
Secondary accession number(s): Q7AF71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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