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Protein

Pectinesterase

Gene

ybhC

Organism
Escherichia coli O157:H7
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Pectin + n H2O = n methanol + pectate.UniRule annotation

Pathwayi: pectin degradation

This protein is involved in step 1 of the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pectinesterase (ybhC)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (kduI)
  5. no protein annotated in this organism
This subpathway is part of the pathway pectin degradation, which is itself part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin, the pathway pectin degradation and in Glycan metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl esteraseUniRule annotation, Hydrolase

Enzyme and pathway databases

BioCyciECOL386585:GJFA-801-MONOMER.
ECOO157:YBHC-MONOMER.
UniPathwayiUPA00545; UER00823.

Names & Taxonomyi

Protein namesi
Recommended name:
PectinesteraseUniRule annotation (EC:3.1.1.11UniRule annotation)
Gene namesi
Name:ybhCImported
Ordered Locus Names:ECs0800Imported, Z0943Imported
ORF Names:AO055_04165Imported
OrganismiEscherichia coli O157:H7Imported
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323UniRule annotationAdd
BLAST
Chaini24 – 427404PectinesteraseUniRule annotationPRO_5006776840Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z0943.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini194 – 339146PectinesteraseInterPro annotationAdd
BLAST

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG4105NBR. Bacteria.
COG4677. LUCA.
HOGENOMiHOG000118057.
KOiK01051.
OMAiFNRMWEY.
OrthoDBiEOG6WDSG7.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
InterProiIPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
IPR033131. Pectinesterase_Asp_AS.
IPR000070. Pectinesterase_cat.
[Graphical view]
PfamiPF01095. Pectinesterase. 1 hit.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 2 hits.
PROSITEiPS00503. PECTINESTERASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTFSVSRLA LALAFGVTLT ACSSTPPDQR PSDQTAPGTS SRPILSAKEA
60 70 80 90 100
QNFDAQHYFA SLTPGAAAWN PSPITLPAQP DFVVGPAGTQ GVTHTTIQAA
110 120 130 140 150
VDAAIIKRTN KRQYIAVMPG EYQGTVYVPA APGGITLYGT GEKPIDVKIG
160 170 180 190 200
LSLDGGMSPA DWRHDVNPRG KYMPGKPAWY MYDSCQSKRS DSIGVLCSAV
210 220 230 240 250
FWSQNNGLQL QNLTIENTLG DSVDAGNHPA VALRTDGDQV QINNVNILGR
260 270 280 290 300
QNTFFVTNSG VQNRLETNRQ PRTLVTNSYI EGDVDIVSGR GAVVFDNTEF
310 320 330 340 350
RVVNSRTQQE AYVFAPATLS NIYYGFLAVN SRFNASGDGV AQLGRSLDVD
360 370 380 390 400
ANTNGQVVIR DSAINEGFNT AKPWGDAVIS NRPFAGNTGS VDDSDEIQRN
410 420
LNDTNYNRMW EYNNRGVGSK VVAEAKK
Length:427
Mass (Da):45,981
Last modified:March 1, 2002 - v1
Checksum:i0B33AFA4BF594170
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55101.1.
CP012802 Genomic DNA. Translation: ALH89516.1.
BA000007 Genomic DNA. Translation: BAB34223.1.
PIRiA85580.
H90728.
RefSeqiNP_308827.1. NC_002695.1.
WP_001091577.1. NZ_LMXL01000098.1.

Genome annotation databases

EnsemblBacteriaiAAG55101; AAG55101; Z0943.
GeneIDi917540.
KEGGiece:Z0943.
ecs:ECs0800.
PATRICi18350640. VBIEscCol44059_0825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55101.1.
CP012802 Genomic DNA. Translation: ALH89516.1.
BA000007 Genomic DNA. Translation: BAB34223.1.
PIRiA85580.
H90728.
RefSeqiNP_308827.1. NC_002695.1.
WP_001091577.1. NZ_LMXL01000098.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z0943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG55101; AAG55101; Z0943.
GeneIDi917540.
KEGGiece:Z0943.
ecs:ECs0800.
PATRICi18350640. VBIEscCol44059_0825.

Phylogenomic databases

eggNOGiENOG4105NBR. Bacteria.
COG4677. LUCA.
HOGENOMiHOG000118057.
KOiK01051.
OMAiFNRMWEY.
OrthoDBiEOG6WDSG7.

Enzyme and pathway databases

UniPathwayiUPA00545; UER00823.
BioCyciECOL386585:GJFA-801-MONOMER.
ECOO157:YBHC-MONOMER.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
InterProiIPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
IPR033131. Pectinesterase_Asp_AS.
IPR000070. Pectinesterase_cat.
[Graphical view]
PfamiPF01095. Pectinesterase. 1 hit.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 2 hits.
PROSITEiPS00503. PECTINESTERASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHECImported and SakaiImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EDL933Imported and O157:H7 / EDL933 / ATCC 700927 / EHECImported.
  3. "Draft genome sequence of three European lab-derivates from the enterohemorrhagic E. coli O157:H7 strain EDL933, including two plasmids."
    Fellner L., Huptas C., Simon S., Krementowski A., Scherer S., Neuhaus K.
    Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WS4202Imported.

Entry informationi

Entry nameiQ8X891_ECO57
AccessioniPrimary (citable) accession number: Q8X891
Secondary accession number(s): Q7AGH4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: April 13, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.