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Protein
Submitted name:

Phosphomethylpyrimidine kinase

Gene

thiD

Organism
Escherichia coli O157:H7
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphomethylpyrimidine kinase activity Source: InterPro

GO - Biological processi

  1. thiamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-2866-MONOMER.
ECOO157:THID-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphomethylpyrimidine kinaseImported
Gene namesi
Name:thiDImported
Ordered Locus Names:ECs2906Imported, Z3267Imported
OrganismiEscherichia coli O157:H7Imported
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558 Componenti: Chromosome UP000002519 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi155864.Z3267.

Structurei

3D structure databases

ProteinModelPortaliQ8X7G5.
SMRiQ8X7G5. Positions 1-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000225275.
KOiK00941.
OMAiGPLNHWA.
OrthoDBiEOG6XWV53.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8X7G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRINALTIA GTDPSGGAGI QADLKTFSAL GAYGCSVITA LVAQNTRGVQ
60 70 80 90 100
SVYRIEPDFV AAQLDSVFSD VRIDTTKIGM LAETDIVEAV AERLQRYQIQ
110 120 130 140 150
NVVLDTVMLA KSGDPLLSPS AVATLRSRLL PQVSLITPNL PEAAALLDAP
160 170 180 190 200
HARTEQEMLE QGRALLAMGC GAVLMKGGHL DDEQSPDWLF TREGEQRFTA
210 220 230 240 250
PRIMTKNTHG TGCTLSAALA ALRPRHTNWA DTVQEAKSWL SSALAQADTL
260
EVGHGIGPVH HFHAWW
Length:266
Mass (Da):28,618
Last modified:February 28, 2002 - v1
Checksum:iA8E31593E52196F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57160.1.
BA000007 Genomic DNA. Translation: BAB36329.1.
PIRiB90992.
D85837.
RefSeqiNP_288605.1. NC_002655.2.
NP_310933.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG57160; AAG57160; Z3267.
BAB36329; BAB36329; BAB36329.
GeneIDi916609.
956831.
KEGGiece:Z3267.
ecs:ECs2906.
PATRICi18355195. VBIEscCol44059_2798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57160.1.
BA000007 Genomic DNA. Translation: BAB36329.1.
PIRiB90992.
D85837.
RefSeqiNP_288605.1. NC_002655.2.
NP_310933.1. NC_002695.1.

3D structure databases

ProteinModelPortaliQ8X7G5.
SMRiQ8X7G5. Positions 1-266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z3267.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG57160; AAG57160; Z3267.
BAB36329; BAB36329; BAB36329.
GeneIDi916609.
956831.
KEGGiece:Z3267.
ecs:ECs2906.
PATRICi18355195. VBIEscCol44059_2798.

Phylogenomic databases

HOGENOMiHOG000225275.
KOiK00941.
OMAiGPLNHWA.
OrthoDBiEOG6XWV53.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-2866-MONOMER.
ECOO157:THID-MONOMER.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequence of the prophage VT2-Sakai carrying the verotoxin 2 genes of the enterohemorrhagic Escherichia coli O157:H7 derived from the Sakai outbreak."
    Makino K., Yokoyama K., Kubota Y., Yutsudo C.H., Kimura S., Kurokawa K., Ishii K., Hattori M., Tatsuno I., Abe H., Iida T., Yamamoto K., Ohnishi M., Hayashi T., Yasunaga T., Honda T., Sasakawa C., Shinagawa H.
    Genes Genet. Syst. 74:227-239(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SakaiImported.
  2. "Complete nucleotide sequence of the prophage VT1-Sakai carrying the Shiga toxin 1 genes of the enterohemorrhagic Escherichia coli O157:H7 strain derived from the Sakai outbreak."
    Yokoyama K., Makino K., Kubota Y., Watanabe M., Kimura S., Yutsudo C.H., Kurokawa K., Ishii K., Hattori M., Abe H., Iida T., Yamamoto K., Hayashi T., Yasunaga T., Honda T., Sasakawa C., Shinagawa H.
    Gene 258:127-139(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SakaiImported.
  3. "Comparative analysis of the whole set of rRNA operons between an enterohemorrhagic Escherichia coli O157:H7 Sakai strain and an Escherichia coli K-12 strain MG1655."
    Ohnishi M., Murata T., Nakayama K., Kuhara S., Hattori M., Kurokawa K., Yasunaga T., Yokoyama K., Makino K., Shinagawa H., Hayashi T.
    Syst. Appl. Microbiol. 23:315-324(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SakaiImported.
  4. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHECImported and SakaiImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EDL933Imported and O157:H7 / EDL933 / ATCC 700927 / EHECImported.

Entry informationi

Entry nameiQ8X7G5_ECO57
AccessioniPrimary (citable) accession number: Q8X7G5
Secondary accession number(s): Q7ACK6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 28, 2002
Last sequence update: February 28, 2002
Last modified: March 31, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.