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Q8X7B7

- TRPC_ECO57

UniProt

Q8X7B7 - TRPC_ECO57

Protein

Tryptophan biosynthesis protein TrpCF

Gene

trpC

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (19 Mar 2014)
      Previous versions | rss
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    Functioni

    Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain By similarity.By similarity

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
    1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

    Pathwayi

    GO - Molecular functioni

    1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
    2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Isomerase, Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-1810-MONOMER.
    UniPathwayiUPA00035; UER00042.
    UPA00035; UER00043.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan biosynthesis protein TrpCF
    Including the following 2 domains:
    Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
    Short name:
    IGPS
    N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:trpC
    Ordered Locus Names:Z2549, ECs1834
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 453453Tryptophan biosynthesis protein TrpCFPRO_0000154278Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi155864.Z2549.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8X7B7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 257257Indole-3-glycerol phosphate synthaseAdd
    BLAST
    Regioni258 – 453196N-(5'-phosphoribosyl)anthranilate isomeraseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the TrpC family.Curated
    In the C-terminal section; belongs to the TrpF family.Curated

    Phylogenomic databases

    eggNOGiCOG0134.
    HOGENOMiHOG000280458.
    KOiK13498.
    OMAiEKYFQGD.
    OrthoDBiEOG6WT8JX.

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    HAMAPiMF_00134_B. IGPS_B.
    MF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 2 hits.
    PROSITEiPS00614. IGPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8X7B7-1 [UniParc]FASTAAdd to Basket

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    MMQTVLAKIV ADKAIWVEAR KQQQPLASFQ NEVQPSTRHF YDALQGARTA    50
    FILECKKASP SKGVICDDFD PARIAAIYKH YASAISVLTD EKYFQGSFDF 100
    LPIVSQIAPQ PILCKDFIID PYQIYLARYY QADACLLMLS VLDDEQYRQL 150
    AAVAHSLKMG VLTEVSNEEE LERAIALGAK VVGINNRDLR DLSIDLNRTR 200
    ELAPKLGHNV TVISESGINT YAQVRELSHF ADGFLIGSAL MAHDDLHAAV 250
    RRVLLGENKV CGLTRGQDAK AAYDAGAIYG GLIFVATSPR CVNVEQAQEV 300
    MAAAPLQYVG VFRNHDIADV LDKAKVLSLV AVQLHGNEDQ LYIDTLREAL 350
    PAHVAIWKAL SVGETLPARE LQHVDKYVLD NGQGGSGQRF DWSLLNGQSL 400
    GNVLLAGGLG ADNCVEAAQT GCAGLDFNSA VESQPGIKDA RLLASVFQTL 450
    RAY 453
    Length:453
    Mass (Da):49,433
    Last modified:March 19, 2014 - v3
    Checksum:i7C30E71A58270033
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG56554.1.
    BA000007 Genomic DNA. Translation: BAB35257.1.
    PIRiB90858.
    F85761.
    RefSeqiNP_287937.1. NC_002655.2.
    NP_309861.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG56554; AAG56554; Z2549.
    BAB35257; BAB35257; BAB35257.
    GeneIDi912854.
    961398.
    KEGGiece:Z2549.
    ecs:ECs1834.
    PATRICi18353731. VBIEscCol44059_2082.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG56554.1 .
    BA000007 Genomic DNA. Translation: BAB35257.1 .
    PIRi B90858.
    F85761.
    RefSeqi NP_287937.1. NC_002655.2.
    NP_309861.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali Q8X7B7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z2549.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG56554 ; AAG56554 ; Z2549 .
    BAB35257 ; BAB35257 ; BAB35257 .
    GeneIDi 912854.
    961398.
    KEGGi ece:Z2549.
    ecs:ECs1834.
    PATRICi 18353731. VBIEscCol44059_2082.

    Phylogenomic databases

    eggNOGi COG0134.
    HOGENOMi HOG000280458.
    KOi K13498.
    OMAi EKYFQGD.
    OrthoDBi EOG6WT8JX.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .
    UPA00035 ; UER00043 .
    BioCyci ECOL386585:GJFA-1810-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    HAMAPi MF_00134_B. IGPS_B.
    MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 2 hits.
    PROSITEi PS00614. IGPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiTRPC_ECO57
    AccessioniPrimary (citable) accession number: Q8X7B7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 19, 2014
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3