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Protein

CDP-diacylglycerol pyrophosphatase

Gene

cdh

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

CDP-diacylglycerol + H2O = CMP + phosphatidate.UniRule annotation

Pathwayi: CDP-diacylglycerol degradation

This protein is involved in step 1 of the subpathway that synthesizes phosphatidate from CDP-diacylglycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. CDP-diacylglycerol pyrophosphatase (cdh)
This subpathway is part of the pathway CDP-diacylglycerol degradation, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidate from CDP-diacylglycerol, the pathway CDP-diacylglycerol degradation and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4833-MONOMER.
ECOO157:CDH-MONOMER.
UniPathwayiUPA00609; UER00664.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol pyrophosphataseUniRule annotation (EC:3.6.1.26UniRule annotation)
Alternative name(s):
CDP-diacylglycerol phosphatidylhydrolaseUniRule annotation
CDP-diglyceride hydrolaseUniRule annotation
Gene namesi
Name:cdhUniRule annotation
Ordered Locus Names:Z5463, ECs4843
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251CDP-diacylglycerol pyrophosphatasePRO_0000198575Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5463.

Structurei

Secondary structure

1
251
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 408Combined sources
Helixi42 – 498Combined sources
Beta strandi55 – 584Combined sources
Turni60 – 623Combined sources
Beta strandi63 – 686Combined sources
Beta strandi70 – 745Combined sources
Beta strandi76 – 827Combined sources
Helixi90 – 934Combined sources
Helixi100 – 1067Combined sources
Helixi109 – 1157Combined sources
Helixi121 – 1233Combined sources
Beta strandi124 – 1296Combined sources
Helixi131 – 1333Combined sources
Beta strandi141 – 1466Combined sources
Helixi148 – 1558Combined sources
Helixi156 – 1605Combined sources
Beta strandi178 – 1825Combined sources
Helixi184 – 1896Combined sources
Helixi192 – 1998Combined sources
Turni201 – 2055Combined sources
Helixi207 – 2093Combined sources
Beta strandi210 – 2167Combined sources
Beta strandi222 – 2287Combined sources
Turni231 – 2344Combined sources
Helixi239 – 2424Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2POFX-ray1.40A/B27-251[»]
ProteinModelPortaliQ8X7A5.
SMRiQ8X7A5. Positions 31-250.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8X7A5.

Family & Domainsi

Sequence similaritiesi

Belongs to the Cdh family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EAF. Bacteria.
COG2134. LUCA.
HOGENOMiHOG000048713.
KOiK01521.
OMAiRWSPLSG.
OrthoDBiEOG6FV82N.

Family and domain databases

HAMAPiMF_00319. Cdh.
InterProiIPR003763. CDP-diacylglyc_Pase.
IPR015993. CDP-diacylglyc_Pase_proteobac.
IPR011146. HIT-like.
[Graphical view]
PfamiPF02611. CDH. 1 hit.
[Graphical view]
PIRSFiPIRSF001273. CDH. 1 hit.
SUPFAMiSSF54197. SSF54197. 1 hit.
TIGRFAMsiTIGR00672. cdh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8X7A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ
60 70 80 90 100
NPSPCAEVKP NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF
110 120 130 140 150
FWLAWQARDF MSKKYGQPVP DRAVSLAINS RTGRTQNHFH IHISCIRPDV
160 170 180 190 200
REQLDNNLAN ISSRWLPLPG GLRGHEYLAR RVTESELVQR SPFMMLAEEV
210 220 230 240 250
PEAREHMGSY GLAMVRQSDN SFVLLATQRN LLTLNRASAE EIQDHQCEIL

R
Length:251
Mass (Da):28,383
Last modified:March 1, 2002 - v1
Checksum:iC987D3A4B12BE5F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59111.1.
BA000007 Genomic DNA. Translation: BAB38266.1.
PIRiC86081.
C91234.
RefSeqiNP_312870.1. NC_002695.1.
WP_000708998.1. NZ_LPWC01000146.1.

Genome annotation databases

EnsemblBacteriaiAAG59111; AAG59111; Z5463.
BAB38266; BAB38266; BAB38266.
GeneIDi915054.
KEGGiece:Z5463.
ecs:ECs4843.
PATRICi18359347. VBIEscCol44059_4823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59111.1.
BA000007 Genomic DNA. Translation: BAB38266.1.
PIRiC86081.
C91234.
RefSeqiNP_312870.1. NC_002695.1.
WP_000708998.1. NZ_LPWC01000146.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2POFX-ray1.40A/B27-251[»]
ProteinModelPortaliQ8X7A5.
SMRiQ8X7A5. Positions 31-250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z5463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG59111; AAG59111; Z5463.
BAB38266; BAB38266; BAB38266.
GeneIDi915054.
KEGGiece:Z5463.
ecs:ECs4843.
PATRICi18359347. VBIEscCol44059_4823.

Phylogenomic databases

eggNOGiENOG4105EAF. Bacteria.
COG2134. LUCA.
HOGENOMiHOG000048713.
KOiK01521.
OMAiRWSPLSG.
OrthoDBiEOG6FV82N.

Enzyme and pathway databases

UniPathwayiUPA00609; UER00664.
BioCyciECOL386585:GJFA-4833-MONOMER.
ECOO157:CDH-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8X7A5.

Family and domain databases

HAMAPiMF_00319. Cdh.
InterProiIPR003763. CDP-diacylglyc_Pase.
IPR015993. CDP-diacylglyc_Pase_proteobac.
IPR011146. HIT-like.
[Graphical view]
PfamiPF02611. CDH. 1 hit.
[Graphical view]
PIRSFiPIRSF001273. CDH. 1 hit.
SUPFAMiSSF54197. SSF54197. 1 hit.
TIGRFAMsiTIGR00672. cdh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiCDH_ECO57
AccessioniPrimary (citable) accession number: Q8X7A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.