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Protein

Acetylornithine deacetylase

Gene

argE

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde.By similarity

Catalytic activityi

N2-acetyl-L-ornithine + H2O = acetate + L-ornithine.

Cofactori

Protein has several cofactor binding sites:
  • Zn2+By similarity, Co2+By similarityNote: Binds 2 Zn2+ or Co2+ ions per subunit.By similarity
  • glutathioneBy similarity

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear).
Proteins known to be involved in this subpathway in this organism are:
  1. Acetylornithine deacetylase (argE)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear), the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Cobalt or zinc 1By similarity1
Active sitei82By similarity1
Metal bindingi112Cobalt or zinc 1By similarity1
Metal bindingi112Cobalt or zinc 2By similarity1
Active sitei144Proton acceptorBy similarity1
Metal bindingi145Cobalt or zinc 2By similarity1
Metal bindingi169Cobalt or zinc 1By similarity1
Metal bindingi355Cobalt or zinc 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandCobalt, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00068; UER00110

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylase (EC:3.5.1.16)
Short name:
AO
Short name:
Acetylornithinase
Alternative name(s):
N-acetylornithinase
Short name:
NAO
Gene namesi
Name:argE
Ordered Locus Names:Z5515, ECs4886
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001852411 – 383Acetylornithine deacetylaseAdd BLAST383

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi155864.Z5515

Structurei

3D structure databases

ProteinModelPortaliQ8X742
SMRiQ8X742
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family. ArgE subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CWC Bacteria
COG0624 LUCA
HOGENOMiHOG000243769
KOiK01438
OMAiCAHQPGE

Family and domain databases

CDDicd03894 M20_ArgE, 1 hit
HAMAPiMF_01108 ArgE, 1 hit
InterProiView protein in InterPro
IPR010169 AcOrn-deacetyl
IPR001261 ArgE/DapE_CS
IPR036264 Bact_exopeptidase_dim_dom
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer
PANTHERiPTHR43808:SF1 PTHR43808:SF1, 1 hit
PfamiView protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit
SUPFAMiSSF55031 SSF55031, 1 hit
TIGRFAMsiTIGR01892 AcOrn-deacetyl, 1 hit
PROSITEiView protein in PROSITE
PS00758 ARGE_DAPE_CPG2_1, 1 hit
PS00759 ARGE_DAPE_CPG2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8X742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKLPPFIE IYRALIATPS ISATEEALDQ SNADLITLLA DWFKDLGFNV
60 70 80 90 100
EVQPVPGTRN KFNMLASTGQ GAGGLLLAGH TDTVPFDDGR WTRDPFTLTE
110 120 130 140 150
HDGKLYGLGT ADMKGFFAFI LDALRDVDVT KLKKPLYILA TADEETSMAG
160 170 180 190 200
ARYFAETTAL RPDCAIIGEP TSLQPVRAHK GHISNAIRIQ GQSGHSSDPA
210 220 230 240 250
RGVNAIELMH DAIGHILQLR DNLKERYHYE AFTVPYPTLN LGHIHGGDAS
260 270 280 290 300
NRICAWCELH MDIRPLPGMT LNELNGLLND ALAPVSERWP GRLTVDELHP
310 320 330 340 350
PIPGYECPPN HQLVEVVEKL LGAKTEVVNY CTEAPFIQTL CPTLVLGPGS
360 370 380
INQAHQPDEY LETRFIKPTR ELITQVIHHF CWH
Length:383
Mass (Da):42,418
Last modified:March 1, 2002 - v1
Checksum:iB314804C45A29320
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG59159.1
BA000007 Genomic DNA Translation: BAB38309.1
PIRiC86087
F91239
RefSeqiNP_312913.1, NC_002695.1
WP_001301638.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG59159; AAG59159; Z5515
BAB38309; BAB38309; BAB38309
GeneIDi914989
KEGGiece:Z5515
ecs:ECs4886
PATRICifig|386585.9.peg.5110

Similar proteinsi

Entry informationi

Entry nameiARGE_ECO57
AccessioniPrimary (citable) accession number: Q8X742
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health