Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isocitrate dehydrogenase [NADP]

Gene

icdA

Organism
Escherichia coli O157:H7
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciECOL386585:GJFA-1590-MONOMER.
ECOO157:ICDA-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdAImported
Ordered Locus Names:ECs1608Imported, Z1865Imported
ORF Names:A8V30_08380Imported, A8V31_08370Imported, A8V32_08400Imported, JEONG1266_12630Imported
OrganismiEscherichia coli O157:H7Imported
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000069196 Componenti: Chromosome
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome
  • UP000077912 Componenti: Chromosome
  • UP000077982 Componenti: Chromosome
  • UP000077922 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi155864.Z1865.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 412385Iso_dhInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108HMX. Bacteria.
COG0538. LUCA.
HOGENOMiHOG000021113.
KOiK00031.
OMAiTERESWI.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 3 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKVVVPAQ GKKITLQNGK LNVPENPIIP YIEGDGIGVD VTPAMLKVVD
60 70 80 90 100
AAVEKAYKGE RKISWMEIYT GEKSTQVYGQ DVWLPAETLD LIREYRVAIK
110 120 130 140 150
GPLTTPVGGG IRSLNVALRQ ELDLYICLRP VRYYQGTPSP VKHPELTDMV
160 170 180 190 200
IFRENSEDIY AGIEWKADSA DAEKVIKFLR EEMGVKKIRF PEHCGIGIKP
210 220 230 240 250
CSEEGTKRLV RAAIEYAIAN DRDSVTLVHK GNIMKFTEGA FKDWGYELAR
260 270 280 290 300
EEFGGELIDG GPWLKVKNPN TGKEIVIKDV IADAFLQQIL LRPAEYDVIA
310 320 330 340 350
CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK
360 370 380 390 400
VNPGSIILSA EMMLRHMGWT EAADLIVKGM EGAINAKTVT YDFERLMEGA
410
KLLKCSEFGD AIIKNM
Length:416
Mass (Da):45,771
Last modified:March 1, 2002 - v1
Checksum:iECD2BFB29031F9C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55962.1.
CP014314 Genomic DNA. Translation: AMG78871.1.
CP015842 Genomic DNA. Translation: ANG68136.1.
CP015843 Genomic DNA. Translation: ANG73697.1.
CP015846 Genomic DNA. Translation: ANG79318.1.
BA000007 Genomic DNA. Translation: BAB35031.1.
PIRiF85687.
H90829.
RefSeqiNP_309635.1. NC_002695.1.
WP_000444477.1. NZ_LPXF01000169.1.

Genome annotation databases

EnsemblBacteriaiAAG55962; AAG55962; Z1865.
BAB35031; BAB35031; BAB35031.
CTT15306; CTT15306; ERS085335_04218.
CTT24195; CTT24195; ERS085361_04190.
CTU02493; CTU02493; ERS085383_04444.
CTV58023; CTV58023; ERS085404_03658.
CUA47589; CUA47589; ERS139226_04164.
KPO86471; KPO86471; ACU72_05935.
KPP19705; KPP19705; ACU66_05820.
KPP26565; KPP26565; ACU86_13180.
KPP29578; KPP29578; ACU68_01230.
KPP30835; KPP30835; ACU94_27725.
KPP52374; KPP52374; ACU77_03825.
GeneIDi913281.
KEGGiece:Z1865.
ecs:ECs1608.
PATRICi18352453. VBIEscCol44059_1451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55962.1.
CP014314 Genomic DNA. Translation: AMG78871.1.
CP015842 Genomic DNA. Translation: ANG68136.1.
CP015843 Genomic DNA. Translation: ANG73697.1.
CP015846 Genomic DNA. Translation: ANG79318.1.
BA000007 Genomic DNA. Translation: BAB35031.1.
PIRiF85687.
H90829.
RefSeqiNP_309635.1. NC_002695.1.
WP_000444477.1. NZ_LPXF01000169.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z1865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG55962; AAG55962; Z1865.
BAB35031; BAB35031; BAB35031.
CTT15306; CTT15306; ERS085335_04218.
CTT24195; CTT24195; ERS085361_04190.
CTU02493; CTU02493; ERS085383_04444.
CTV58023; CTV58023; ERS085404_03658.
CUA47589; CUA47589; ERS139226_04164.
KPO86471; KPO86471; ACU72_05935.
KPP19705; KPP19705; ACU66_05820.
KPP26565; KPP26565; ACU86_13180.
KPP29578; KPP29578; ACU68_01230.
KPP30835; KPP30835; ACU94_27725.
KPP52374; KPP52374; ACU77_03825.
GeneIDi913281.
KEGGiece:Z1865.
ecs:ECs1608.
PATRICi18352453. VBIEscCol44059_1451.

Phylogenomic databases

eggNOGiENOG4108HMX. Bacteria.
COG0538. LUCA.
HOGENOMiHOG000021113.
KOiK00031.
OMAiTERESWI.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-1590-MONOMER.
ECOO157:ICDA-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 3 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8X722_ECO57
AccessioniPrimary (citable) accession number: Q8X722
Secondary accession number(s): Q7AF13
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.