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Q8X6R8

- FUCA_ECO57

UniProt

Q8X6R8 - FUCA_ECO57

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Protein

L-fuculose phosphate aldolase

Gene
fucA, Z4117, ECs3660
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde By similarity.UniRule annotation

Catalytic activityi

L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Proton acceptor By similarity
Metal bindingi73 – 731Zinc By similarity
Metal bindingi92 – 921Zinc By similarity
Metal bindingi94 – 941Zinc By similarity
Active sitei113 – 1131Proton donor By similarity
Metal bindingi155 – 1551Zinc By similarity

GO - Molecular functioni

  1. L-fuculose-phosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fucose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3624-MONOMER.
ECOO157:FUCA-MONOMER.
UniPathwayiUPA00563; UER00626.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fuculose phosphate aldolase (EC:4.1.2.17)
Alternative name(s):
L-fuculose-1-phosphate aldolase
Gene namesi
Name:fucA
Ordered Locus Names:Z4117, ECs3660
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215L-fuculose phosphate aldolaseUniRule annotationPRO_0000162926Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z4117.

Structurei

3D structure databases

ProteinModelPortaliQ8X6R8.
SMRiQ8X6R8. Positions 1-210.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0235.
HOGENOMiHOG000218184.
KOiK01628.
OMAiYATFGTH.
OrthoDBiEOG6HQSSQ.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
HAMAPiMF_00987. FucA.
InterProiIPR001303. Aldolase_II/adducin_N.
IPR004782. FucA.
[Graphical view]
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.
TIGRFAMsiTIGR01086. fucA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8X6R8-1 [UniParc]FASTAAdd to Basket

« Hide

MERNKLARQI IDTCLEMTRL GLNQGTAGNV SVRYQDGMLI TPTGIPYEKL    50
TESHIVFIDG NGKHEEGKLP SSEWRFHMAA YQSRPDANAV VHNHAVHCTA 100
VSILNRPIPA IHYMIAAAGG NSIPCAPYAT FGTRELSEHV ALALKNRKAT 150
LLQHHGLIAC EVNLEKALWL AHEVEVLAQL YLTTLAITDP VPVLSDEEIA 200
VVLEKFKTYG LRIEE 215
Length:215
Mass (Da):23,785
Last modified:March 1, 2002 - v1
Checksum:i072E4EC5A94E76D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG57914.1.
BA000007 Genomic DNA. Translation: BAB37083.1.
PIRiD91086.
F85931.
RefSeqiNP_289355.1. NC_002655.2.
NP_311687.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG57914; AAG57914; Z4117.
BAB37083; BAB37083; BAB37083.
GeneIDi916460.
958302.
KEGGiece:Z4117.
ecs:ECs3660.
PATRICi18356799. VBIEscCol44059_3582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG57914.1 .
BA000007 Genomic DNA. Translation: BAB37083.1 .
PIRi D91086.
F85931.
RefSeqi NP_289355.1. NC_002655.2.
NP_311687.1. NC_002695.1.

3D structure databases

ProteinModelPortali Q8X6R8.
SMRi Q8X6R8. Positions 1-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z4117.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG57914 ; AAG57914 ; Z4117 .
BAB37083 ; BAB37083 ; BAB37083 .
GeneIDi 916460.
958302.
KEGGi ece:Z4117.
ecs:ECs3660.
PATRICi 18356799. VBIEscCol44059_3582.

Phylogenomic databases

eggNOGi COG0235.
HOGENOMi HOG000218184.
KOi K01628.
OMAi YATFGTH.
OrthoDBi EOG6HQSSQ.

Enzyme and pathway databases

UniPathwayi UPA00563 ; UER00626 .
BioCyci ECOL386585:GJFA-3624-MONOMER.
ECOO157:FUCA-MONOMER.

Family and domain databases

Gene3Di 3.40.225.10. 1 hit.
HAMAPi MF_00987. FucA.
InterProi IPR001303. Aldolase_II/adducin_N.
IPR004782. FucA.
[Graphical view ]
Pfami PF00596. Aldolase_II. 1 hit.
[Graphical view ]
SMARTi SM01007. Aldolase_II. 1 hit.
[Graphical view ]
SUPFAMi SSF53639. SSF53639. 1 hit.
TIGRFAMsi TIGR01086. fucA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiFUCA_ECO57
AccessioniPrimary (citable) accession number: Q8X6R8
Secondary accession number(s): Q7AB69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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