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Q8X6R8

- FUCA_ECO57

UniProt

Q8X6R8 - FUCA_ECO57

Protein

L-fuculose phosphate aldolase

Gene

fucA

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde.UniRule annotation

    Catalytic activityi

    L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731Proton acceptorUniRule annotation
    Metal bindingi73 – 731ZincUniRule annotation
    Metal bindingi92 – 921ZincUniRule annotation
    Metal bindingi94 – 941ZincUniRule annotation
    Active sitei113 – 1131Proton donorUniRule annotation
    Metal bindingi155 – 1551ZincUniRule annotation

    GO - Molecular functioni

    1. L-fuculose-phosphate aldolase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fucose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-3624-MONOMER.
    ECOO157:FUCA-MONOMER.
    UniPathwayiUPA00563; UER00626.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-fuculose phosphate aldolaseUniRule annotation (EC:4.1.2.17UniRule annotation)
    Alternative name(s):
    L-fuculose-1-phosphate aldolaseUniRule annotation
    Gene namesi
    Name:fucAUniRule annotation
    Ordered Locus Names:Z4117, ECs3660
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215L-fuculose phosphate aldolasePRO_0000162926Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi155864.Z4117.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8X6R8.
    SMRiQ8X6R8. Positions 1-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldolase class II family. AraD/FucA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0235.
    HOGENOMiHOG000218184.
    KOiK01628.
    OMAiYATFGTH.
    OrthoDBiEOG6HQSSQ.

    Family and domain databases

    Gene3Di3.40.225.10. 1 hit.
    HAMAPiMF_00987. FucA.
    InterProiIPR001303. Aldolase_II/adducin_N.
    IPR004782. FucA.
    [Graphical view]
    PfamiPF00596. Aldolase_II. 1 hit.
    [Graphical view]
    SMARTiSM01007. Aldolase_II. 1 hit.
    [Graphical view]
    SUPFAMiSSF53639. SSF53639. 1 hit.
    TIGRFAMsiTIGR01086. fucA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8X6R8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERNKLARQI IDTCLEMTRL GLNQGTAGNV SVRYQDGMLI TPTGIPYEKL    50
    TESHIVFIDG NGKHEEGKLP SSEWRFHMAA YQSRPDANAV VHNHAVHCTA 100
    VSILNRPIPA IHYMIAAAGG NSIPCAPYAT FGTRELSEHV ALALKNRKAT 150
    LLQHHGLIAC EVNLEKALWL AHEVEVLAQL YLTTLAITDP VPVLSDEEIA 200
    VVLEKFKTYG LRIEE 215
    Length:215
    Mass (Da):23,785
    Last modified:March 1, 2002 - v1
    Checksum:i072E4EC5A94E76D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57914.1.
    BA000007 Genomic DNA. Translation: BAB37083.1.
    PIRiD91086.
    F85931.
    RefSeqiNP_289355.1. NC_002655.2.
    NP_311687.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG57914; AAG57914; Z4117.
    BAB37083; BAB37083; BAB37083.
    GeneIDi916460.
    958302.
    KEGGiece:Z4117.
    ecs:ECs3660.
    PATRICi18356799. VBIEscCol44059_3582.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57914.1 .
    BA000007 Genomic DNA. Translation: BAB37083.1 .
    PIRi D91086.
    F85931.
    RefSeqi NP_289355.1. NC_002655.2.
    NP_311687.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali Q8X6R8.
    SMRi Q8X6R8. Positions 1-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z4117.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG57914 ; AAG57914 ; Z4117 .
    BAB37083 ; BAB37083 ; BAB37083 .
    GeneIDi 916460.
    958302.
    KEGGi ece:Z4117.
    ecs:ECs3660.
    PATRICi 18356799. VBIEscCol44059_3582.

    Phylogenomic databases

    eggNOGi COG0235.
    HOGENOMi HOG000218184.
    KOi K01628.
    OMAi YATFGTH.
    OrthoDBi EOG6HQSSQ.

    Enzyme and pathway databases

    UniPathwayi UPA00563 ; UER00626 .
    BioCyci ECOL386585:GJFA-3624-MONOMER.
    ECOO157:FUCA-MONOMER.

    Family and domain databases

    Gene3Di 3.40.225.10. 1 hit.
    HAMAPi MF_00987. FucA.
    InterProi IPR001303. Aldolase_II/adducin_N.
    IPR004782. FucA.
    [Graphical view ]
    Pfami PF00596. Aldolase_II. 1 hit.
    [Graphical view ]
    SMARTi SM01007. Aldolase_II. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53639. SSF53639. 1 hit.
    TIGRFAMsi TIGR01086. fucA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiFUCA_ECO57
    AccessioniPrimary (citable) accession number: Q8X6R8
    Secondary accession number(s): Q7AB69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3