Q8X6R8 (FUCA_ECO57) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-fuculose phosphate aldolase
EC=4.1.2.17

Alternative name(s):
L-fuculose-1-phosphate aldolase

Gene names

Name:	fucA
Ordered Locus Names:	Z4117, ECs3660

Organism

Escherichia coli O157:H7 [Complete proteome] [HAMAP]

Taxonomic identifier

83334 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the aldolase class II family. AraD/FucA subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Fucose metabolism
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fucose catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	L-fuculose-phosphate aldolase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	L-fuculose phosphate aldolase		PRO_0000162926
Sites
	Active site	73	1	Proton acceptor By similarity
	Active site	113	1	Proton donor By similarity
	Metal binding	73	1	Zinc By similarity
	Metal binding	92	1	Zinc By similarity
	Metal binding	94	1	Zinc By similarity
	Metal binding	155	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8X6R8 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 072E4EC5A94E76D1	FASTA	215	23,785
	10 20 30 40 50 60 MERNKLARQI IDTCLEMTRL GLNQGTAGNV SVRYQDGMLI TPTGIPYEKL TESHIVFIDG 70 80 90 100 110 120 NGKHEEGKLP SSEWRFHMAA YQSRPDANAV VHNHAVHCTA VSILNRPIPA IHYMIAAAGG 130 140 150 160 170 180 NSIPCAPYAT FGTRELSEHV ALALKNRKAT LLQHHGLIAC EVNLEKALWL AHEVEVLAQL 190 200 210 YLTTLAITDP VPVLSDEEIA VVLEKFKTYG LRIEE

References

[1]

"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. , Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R. Nature 409:529-533(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.

[2]

"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. , Kuhara S., Shiba T., Hattori M., Shinagawa H. DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005174 Genomic DNA. Translation: AAG57914.1. BA000007 Genomic DNA. Translation: BAB37083.1.
PIR	D91086. F85931.
RefSeq	NP_289355.1. NC_002655.2. NP_311687.1. NC_002695.1.
3D structure databases
ProteinModelPortal	Q8X6R8.
SMR	Q8X6R8. Positions 1-210.
ModBase	Search...
Protein-protein interaction databases
STRING	155864.Z4117.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAG57914; AAG57914; Z4117. BAB37083; BAB37083; BAB37083.
GeneID	916460. 958302.
KEGG	ece:Z4117. ecs:ECs3660.
PATRIC	18356799. VBIEscCol44059_3582.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0235.
HOGENOM	HOG000218184.
KO	K01628.
OMA	TFGTAEL.
ProtClustDB	PRK08087.
Enzyme and pathway databases
BioCyc	ECOL386585:GJFA-3624-MONOMER.
UniPathway	UPA00563; UER00626.
Family and domain databases
Gene3D	3.40.225.10. 1 hit.
InterPro	IPR001303. Aldolase_II/adducin_N. IPR004782. FucA. [Graphical view]
Pfam	PF00596. Aldolase_II. 1 hit. [Graphical view]
SMART	SM01007. Aldolase_II. 1 hit. [Graphical view]
SUPFAM	SSF53639. Aldolase_II_N. 1 hit.
TIGRFAMs	TIGR01086. fucA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FUCA_ECO57

Accession

Primary (citable) accession number: Q8X6R8
Secondary accession number(s): Q7AB69

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program