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Protein

L-fuculose phosphate aldolase

Gene

fucA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde.UniRule annotation

Catalytic activityi

L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 3 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. L-fuculokinase (fucK)
  3. L-fuculose phosphate aldolase (fucA)
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Proton acceptorUniRule annotation1
Metal bindingi73ZincUniRule annotation1
Metal bindingi92ZincUniRule annotation1
Metal bindingi94ZincUniRule annotation1
Active sitei113Proton donorUniRule annotation1
Metal bindingi155ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processCarbohydrate metabolism, Fucose metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00563; UER00626

Names & Taxonomyi

Protein namesi
Recommended name:
L-fuculose phosphate aldolaseUniRule annotation (EC:4.1.2.17UniRule annotation)
Alternative name(s):
L-fuculose-1-phosphate aldolaseUniRule annotation
Gene namesi
Name:fucAUniRule annotation
Ordered Locus Names:Z4117, ECs3660
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001629261 – 215L-fuculose phosphate aldolaseAdd BLAST215

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z4117

Structurei

3D structure databases

ProteinModelPortaliQ8X6R8
SMRiQ8X6R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldolase class II family. AraD/FucA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107W7X Bacteria
COG0235 LUCA
HOGENOMiHOG000218184
KOiK01628
OMAiLCEQYWR

Family and domain databases

Gene3Di3.40.225.10, 1 hit
HAMAPiMF_00987 FucA, 1 hit
InterProiView protein in InterPro
IPR001303 Aldolase_II/adducin_N
IPR036409 Aldolase_II/adducin_N_sf
IPR004782 FucA
PfamiView protein in Pfam
PF00596 Aldolase_II, 1 hit
SMARTiView protein in SMART
SM01007 Aldolase_II, 1 hit
SUPFAMiSSF53639 SSF53639, 1 hit
TIGRFAMsiTIGR01086 fucA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8X6R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERNKLARQI IDTCLEMTRL GLNQGTAGNV SVRYQDGMLI TPTGIPYEKL
60 70 80 90 100
TESHIVFIDG NGKHEEGKLP SSEWRFHMAA YQSRPDANAV VHNHAVHCTA
110 120 130 140 150
VSILNRPIPA IHYMIAAAGG NSIPCAPYAT FGTRELSEHV ALALKNRKAT
160 170 180 190 200
LLQHHGLIAC EVNLEKALWL AHEVEVLAQL YLTTLAITDP VPVLSDEEIA
210
VVLEKFKTYG LRIEE
Length:215
Mass (Da):23,785
Last modified:March 1, 2002 - v1
Checksum:i072E4EC5A94E76D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG57914.1
BA000007 Genomic DNA Translation: BAB37083.1
PIRiD91086
F85931
RefSeqiNP_311687.1, NC_002695.1
WP_000440775.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG57914; AAG57914; Z4117
BAB37083; BAB37083; BAB37083
GeneIDi916460
KEGGiece:Z4117
ecs:ECs3660
PATRICifig|386585.9.peg.3826

Similar proteinsi

Entry informationi

Entry nameiFUCA_ECO57
AccessioniPrimary (citable) accession number: Q8X6R8
Secondary accession number(s): Q7AB69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health