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Protein

L-fuculokinase

Gene

fucK

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of L-fuculose.UniRule annotation

Catalytic activityi

ATP + L-fuculose = ADP + L-fuculose 1-phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 2 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. L-fuculokinase (fucK)
  3. L-fuculose phosphate aldolase (fucA)
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3627-MONOMER.
ECOO157:FUCK-MONOMER.
UniPathwayiUPA00563; UER00625.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fuculokinaseUniRule annotation (EC:2.7.1.51UniRule annotation)
Alternative name(s):
L-fuculose kinaseUniRule annotation
Gene namesi
Name:fucKUniRule annotation
Ordered Locus Names:Z4120, ECs3663
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472L-fuculokinasePRO_0000059424Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z4120.

Structurei

3D structure databases

ProteinModelPortaliQ8X6R3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMG. Bacteria.
COG1070. LUCA.
HOGENOMiHOG000124178.
KOiK00879.
OMAiATNVRAM.
OrthoDBiEOG6X9MHN.

Family and domain databases

HAMAPiMF_00986. Fuculokinase.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR013450. Fuculokinase.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR02628. fuculo_kin_coli. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X6R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQEVILVLD CGATNVRAIA VNRQGKIVAR ASTPNASDIA MENNTWHQWS
60 70 80 90 100
LDAILQRFAD CCRQINSELT ECHIRGIAVT TFGVDGALVD KQGNLLYPII
110 120 130 140 150
SWKCPRTAAV MDNIERLISA QRLQAISGVG AFSFNTLYKL VWLKENHPQL
160 170 180 190 200
LERAHAWLFI SSLINHRLTG EFTTDITMAG TSQMLDIQQR DFSPQILQAT
210 220 230 240 250
GIPRRLFPRL VEAGEQIGTL QNSAAAMLGL PVGIPVISAG HDTQFALFGA
260 270 280 290 300
GAEQNEPVLS SGTWEILMVR SAQVDTSLLS QYAGSTCELD SQAGLYNPGM
310 320 330 340 350
QWLASGVLEW VRKLFWTAET PWQMLIEEAR LIAPGADGVK MQCDLLSCQN
360 370 380 390 400
AGWQGVTLNT TRGHFYRAAL EGLTAQLQRN LQMLEKIGHF KASELLLVGG
410 420 430 440 450
GSRNTLWNQI KANMLDIPLK VLDDAETTVA GAALFGWYGV GEFNSPEEAR
460 470
AQIHYQFRYF YPQTEPEFIE EV
Length:472
Mass (Da):52,257
Last modified:October 14, 2015 - v2
Checksum:i4651B640494CACFE
GO

Sequence cautioni

The sequence AAG57917.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB37086.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57917.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB37086.1. Different initiation.
PIRiA85932.
G91086.
RefSeqiNP_311690.1. NC_002695.1.
WP_000808389.1. NZ_LMXL01000087.1.

Genome annotation databases

EnsemblBacteriaiAAG57917; AAG57917; Z4120.
BAB37086; BAB37086; BAB37086.
GeneIDi916532.
KEGGiece:Z4120.
ecs:ECs3663.
PATRICi18356805. VBIEscCol44059_3585.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57917.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB37086.1. Different initiation.
PIRiA85932.
G91086.
RefSeqiNP_311690.1. NC_002695.1.
WP_000808389.1. NZ_LMXL01000087.1.

3D structure databases

ProteinModelPortaliQ8X6R3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z4120.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG57917; AAG57917; Z4120.
BAB37086; BAB37086; BAB37086.
GeneIDi916532.
KEGGiece:Z4120.
ecs:ECs3663.
PATRICi18356805. VBIEscCol44059_3585.

Phylogenomic databases

eggNOGiENOG4105CMG. Bacteria.
COG1070. LUCA.
HOGENOMiHOG000124178.
KOiK00879.
OMAiATNVRAM.
OrthoDBiEOG6X9MHN.

Enzyme and pathway databases

UniPathwayiUPA00563; UER00625.
BioCyciECOL386585:GJFA-3627-MONOMER.
ECOO157:FUCK-MONOMER.

Family and domain databases

HAMAPiMF_00986. Fuculokinase.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR013450. Fuculokinase.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR02628. fuculo_kin_coli. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiFUCK_ECO57
AccessioniPrimary (citable) accession number: Q8X6R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 14, 2015
Last modified: March 16, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.