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Protein

L-fuculokinase

Gene

fucK

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of L-fuculose.UniRule annotation

Catalytic activityi

ATP + L-fuculose = ADP + L-fuculose 1-phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 2 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. L-fuculokinase (fucK)
  3. L-fuculose phosphate aldolase (fucA)
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCarbohydrate metabolism, Fucose metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00563; UER00625

Names & Taxonomyi

Protein namesi
Recommended name:
L-fuculokinaseUniRule annotation (EC:2.7.1.51UniRule annotation)
Alternative name(s):
L-fuculose kinaseUniRule annotation
Gene namesi
Name:fucKUniRule annotation
Ordered Locus Names:Z4120, ECs3663
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000594241 – 482L-fuculokinaseAdd BLAST482

Proteomic databases

PRIDEiQ8X6R3

Interactioni

Protein-protein interaction databases

STRINGi155864.Z4120

Structurei

3D structure databases

ProteinModelPortaliQ8X6R3
SMRiQ8X6R3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMG Bacteria
COG1070 LUCA
HOGENOMiHOG000124178
KOiK00879
OMAiKKGRIFC

Family and domain databases

HAMAPiMF_00986 Fuculokinase, 1 hit
InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR013450 Fuculokinase
PANTHERiPTHR10196:SF60 PTHR10196:SF60, 1 hit
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR02628 fuculo_kin_coli, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8X6R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSGYIAGAI MKQEVILVLD CGATNVRAIA VNRQGKIVAR ASTPNASDIA
60 70 80 90 100
MENNTWHQWS LDAILQRFAD CCRQINSELT ECHIRGIAVT TFGVDGALVD
110 120 130 140 150
KQGNLLYPII SWKCPRTAAV MDNIERLISA QRLQAISGVG AFSFNTLYKL
160 170 180 190 200
VWLKENHPQL LERAHAWLFI SSLINHRLTG EFTTDITMAG TSQMLDIQQR
210 220 230 240 250
DFSPQILQAT GIPRRLFPRL VEAGEQIGTL QNSAAAMLGL PVGIPVISAG
260 270 280 290 300
HDTQFALFGA GAEQNEPVLS SGTWEILMVR SAQVDTSLLS QYAGSTCELD
310 320 330 340 350
SQAGLYNPGM QWLASGVLEW VRKLFWTAET PWQMLIEEAR LIAPGADGVK
360 370 380 390 400
MQCDLLSCQN AGWQGVTLNT TRGHFYRAAL EGLTAQLQRN LQMLEKIGHF
410 420 430 440 450
KASELLLVGG GSRNTLWNQI KANMLDIPLK VLDDAETTVA GAALFGWYGV
460 470 480
GEFNSPEEAR AQIHYQFRYF YPQTEPEFIE EV
Length:482
Mass (Da):53,234
Last modified:September 7, 2016 - v3
Checksum:i42C7D3BC97D7D4C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG57917.1
BA000007 Genomic DNA Translation: BAB37086.1
PIRiA85932
G91086
RefSeqiNP_311690.2, NC_002695.1

Genome annotation databases

EnsemblBacteriaiAAG57917; AAG57917; Z4120
BAB37086; BAB37086; BAB37086
GeneIDi916532
KEGGiece:Z4120
ecs:ECs3663
PATRICifig|386585.9.peg.3829

Similar proteinsi

Entry informationi

Entry nameiFUCK_ECO57
AccessioniPrimary (citable) accession number: Q8X6R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: September 7, 2016
Last modified: May 23, 2018
This is version 91 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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