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Q8X6J4

- YAGR_ECO57

UniProt

Q8X6J4 - YAGR_ECO57

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Protein

Putative xanthine dehydrogenase YagR molybdenum-binding subunit

Gene
yagR, Z0350, ECs0314
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi211 – 2111Molybdenum Reviewed prediction
Metal bindingi242 – 2421Molybdenum; via carbonyl oxygen Reviewed prediction
Metal bindingi350 – 3501Molybdenum; via amide nitrogen Reviewed prediction

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. xanthine dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. purine nucleobase metabolic process Source: UniProtKB-KW
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism, Purine salvage

Keywords - Ligandi

Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciECOL386585:GJFA-314-MONOMER.
ECOO157:YAGR-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative xanthine dehydrogenase YagR molybdenum-binding subunit (EC:1.17.1.4)
Gene namesi
Name:yagR
Ordered Locus Names:Z0350, ECs0314
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Putative xanthine dehydrogenase YagR molybdenum-binding subunitPRO_0000166091Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of YagR, YagS and YagT Reviewed prediction.

Protein-protein interaction databases

STRINGi155864.Z0350.

Structurei

3D structure databases

ProteinModelPortaliQ8X6J4.
SMRiQ8X6J4. Positions 17-731.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1529.
HOGENOMiHOG000244716.
KOiK11177.
OMAiTHNLGEC.
OrthoDBiEOG6ZSP3F.

Family and domain databases

Gene3Di3.30.365.10. 6 hits.
3.90.1170.50. 1 hit.
InterProiIPR000674. Ald_Oxase/Xan_DH_a/b.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
[Graphical view]
PfamiPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
[Graphical view]
SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF54665. SSF54665. 1 hit.
SSF56003. SSF56003. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8X6J4-1 [UniParc]FASTAAdd to Basket

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MKFDKPAGEN PIDQLKVVGR PHDRIDGPLK TTGTARYAYE WHEESPNAAY    50
GYIVGSAIAK GRLTALDTDA AQKAPGVLPV ITASNAGALS KGDKNTARLL 100
GGPTIEHYHQ AIALVVAETF EQARAAASLV QAHYRRNKGA YSLADEKQAV 150
SQPPEDTPDK NVGDFDGAFS SAAVKIDATY TTPDQSHMAM EPHASMAVWD 200
GNKLTLWTSN QMIDWCRTDL AKTLKVPVEN VRIISPYIGG GFGGKLFLRS 250
DALLAALAAR AVKRPVKVML PRPSIPNNTT HRPATLQHLR IGADQSGKIT 300
AISHESWSGN LPGGTPETAV QQSELLYAGA NRHTGLRLAT LDLPEGNAMR 350
APGEAPGLMA LEIAIDELAE KAGIDPVEFR ILNDTQIDPA DPTRRFSRRQ 400
LIECLRTGAD KFGWKQRNAT PGQVRDGEWL VGHGVAAGFR NNLLEKSGAR 450
VHLEPNGTVT VETDMTDIGT GSYTILAQTA AEMLGVPLEQ VAVHLGDSSF 500
PVSAGSGGQW GANTSTSGVY AACVKLREMI ASAVGFDPEQ SQFADGKITN 550
GTRSAILHEA TAGGRLTAEE SIEFGTLSKE YQQSTFAGHF VEVGVHSATG 600
EVRVRRMLAV CAAGRILNPK TARSQVIGAM TMGMGAALME ELAVDDRLGY 650
FVNHDMAGYE VPVHADIPKQ EVIFLDDTDP ISSPMKAKGV GELGLCGVSA 700
AIANAVYNAT GIRVRDYPIT LDKLLDKLPD VV 732
Length:732
Mass (Da):78,135
Last modified:March 1, 2002 - v1
Checksum:iA996E91BEB2643F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG54609.1.
BA000007 Genomic DNA. Translation: BAB33737.1.
PIRiB90668.
E85518.
RefSeqiNP_286001.1. NC_002655.2.
NP_308341.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG54609; AAG54609; Z0350.
BAB33737; BAB33737; BAB33737.
GeneIDi914413.
957138.
KEGGiece:Z0350.
ecs:ECs0314.
PATRICi18349570. VBIEscCol44059_0307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG54609.1 .
BA000007 Genomic DNA. Translation: BAB33737.1 .
PIRi B90668.
E85518.
RefSeqi NP_286001.1. NC_002655.2.
NP_308341.1. NC_002695.1.

3D structure databases

ProteinModelPortali Q8X6J4.
SMRi Q8X6J4. Positions 17-731.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z0350.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG54609 ; AAG54609 ; Z0350 .
BAB33737 ; BAB33737 ; BAB33737 .
GeneIDi 914413.
957138.
KEGGi ece:Z0350.
ecs:ECs0314.
PATRICi 18349570. VBIEscCol44059_0307.

Phylogenomic databases

eggNOGi COG1529.
HOGENOMi HOG000244716.
KOi K11177.
OMAi THNLGEC.
OrthoDBi EOG6ZSP3F.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-314-MONOMER.
ECOO157:YAGR-MONOMER.

Family and domain databases

Gene3Di 3.30.365.10. 6 hits.
3.90.1170.50. 1 hit.
InterProi IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
[Graphical view ]
Pfami PF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
[Graphical view ]
SMARTi SM01008. Ald_Xan_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF54665. SSF54665. 1 hit.
SSF56003. SSF56003. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiYAGR_ECO57
AccessioniPrimary (citable) accession number: Q8X6J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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