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Protein

Putative xanthine dehydrogenase YagR molybdenum-binding subunit

Gene

yagR

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

Mo-molybdopterinBy similarityNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi211MolybdenumSequence analysis1
Metal bindingi242Molybdenum; via carbonyl oxygenSequence analysis1
Metal bindingi350Molybdenum; via amide nitrogenSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPurine metabolism, Purine salvage
LigandMetal-binding, Molybdenum, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative xanthine dehydrogenase YagR molybdenum-binding subunit (EC:1.17.1.4)
Gene namesi
Name:yagR
Ordered Locus Names:Z0350, ECs0314
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001660911 – 732Putative xanthine dehydrogenase YagR molybdenum-binding subunitAdd BLAST732

Proteomic databases

PRIDEiQ8X6J4

Interactioni

Subunit structurei

Heterotrimer of YagR, YagS and YagT.Curated

Protein-protein interaction databases

STRINGi155864.Z0350

Structurei

3D structure databases

ProteinModelPortaliQ8X6J4
SMRiQ8X6J4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xanthine dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105C7W Bacteria
COG1529 LUCA
HOGENOMiHOG000244716
KOiK11177
OMAiSWMRAPG

Family and domain databases

InterProiView protein in InterPro
IPR000674 Ald_Oxase/Xan_DH_a/b
IPR036856 Ald_Oxase/Xan_DH_a/b_sf
IPR008274 AldOxase/xan_DH_Mopterin-bd
IPR037165 AldOxase/xan_DH_Mopterin-bd_sf
PfamiView protein in Pfam
PF01315 Ald_Xan_dh_C, 1 hit
PF02738 Ald_Xan_dh_C2, 1 hit
SMARTiView protein in SMART
SM01008 Ald_Xan_dh_C, 1 hit
SUPFAMiSSF54665 SSF54665, 1 hit
SSF56003 SSF56003, 1 hit

Sequencei

Sequence statusi: Complete.

Q8X6J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFDKPAGEN PIDQLKVVGR PHDRIDGPLK TTGTARYAYE WHEESPNAAY
60 70 80 90 100
GYIVGSAIAK GRLTALDTDA AQKAPGVLPV ITASNAGALS KGDKNTARLL
110 120 130 140 150
GGPTIEHYHQ AIALVVAETF EQARAAASLV QAHYRRNKGA YSLADEKQAV
160 170 180 190 200
SQPPEDTPDK NVGDFDGAFS SAAVKIDATY TTPDQSHMAM EPHASMAVWD
210 220 230 240 250
GNKLTLWTSN QMIDWCRTDL AKTLKVPVEN VRIISPYIGG GFGGKLFLRS
260 270 280 290 300
DALLAALAAR AVKRPVKVML PRPSIPNNTT HRPATLQHLR IGADQSGKIT
310 320 330 340 350
AISHESWSGN LPGGTPETAV QQSELLYAGA NRHTGLRLAT LDLPEGNAMR
360 370 380 390 400
APGEAPGLMA LEIAIDELAE KAGIDPVEFR ILNDTQIDPA DPTRRFSRRQ
410 420 430 440 450
LIECLRTGAD KFGWKQRNAT PGQVRDGEWL VGHGVAAGFR NNLLEKSGAR
460 470 480 490 500
VHLEPNGTVT VETDMTDIGT GSYTILAQTA AEMLGVPLEQ VAVHLGDSSF
510 520 530 540 550
PVSAGSGGQW GANTSTSGVY AACVKLREMI ASAVGFDPEQ SQFADGKITN
560 570 580 590 600
GTRSAILHEA TAGGRLTAEE SIEFGTLSKE YQQSTFAGHF VEVGVHSATG
610 620 630 640 650
EVRVRRMLAV CAAGRILNPK TARSQVIGAM TMGMGAALME ELAVDDRLGY
660 670 680 690 700
FVNHDMAGYE VPVHADIPKQ EVIFLDDTDP ISSPMKAKGV GELGLCGVSA
710 720 730
AIANAVYNAT GIRVRDYPIT LDKLLDKLPD VV
Length:732
Mass (Da):78,135
Last modified:March 1, 2002 - v1
Checksum:iA996E91BEB2643F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG54609.1
BA000007 Genomic DNA Translation: BAB33737.1
PIRiB90668
E85518
RefSeqiNP_308341.1, NC_002695.1
WP_000667043.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG54609; AAG54609; Z0350
BAB33737; BAB33737; BAB33737
GeneIDi914413
KEGGiece:Z0350
ecs:ECs0314
PATRICifig|386585.9.peg.408

Similar proteinsi

Entry informationi

Entry nameiYAGR_ECO57
AccessioniPrimary (citable) accession number: Q8X6J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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