Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8X6J4 (YAGR_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative xanthine dehydrogenase YagR molybdenum-binding subunit

EC=1.17.1.4
Gene names
Name:yagR
Ordered Locus Names:Z0350, ECs0314
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length732 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Xanthine + NAD+ + H2O = urate + NADH.

Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactor

Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit By similarity.

Subunit structure

Heterotrimer of YagR, YagS and YagT Potential.

Sequence similarities

Belongs to the xanthine dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 732732Putative xanthine dehydrogenase YagR molybdenum-binding subunit
PRO_0000166091

Sites

Metal binding2111Molybdenum Potential
Metal binding2421Molybdenum; via carbonyl oxygen Potential
Metal binding3501Molybdenum; via amide nitrogen Potential

Sequences

Sequence LengthMass (Da)Tools
Q8X6J4 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: A996E91BEB2643F6

FASTA73278,135
        10         20         30         40         50         60 
MKFDKPAGEN PIDQLKVVGR PHDRIDGPLK TTGTARYAYE WHEESPNAAY GYIVGSAIAK 

        70         80         90        100        110        120 
GRLTALDTDA AQKAPGVLPV ITASNAGALS KGDKNTARLL GGPTIEHYHQ AIALVVAETF 

       130        140        150        160        170        180 
EQARAAASLV QAHYRRNKGA YSLADEKQAV SQPPEDTPDK NVGDFDGAFS SAAVKIDATY 

       190        200        210        220        230        240 
TTPDQSHMAM EPHASMAVWD GNKLTLWTSN QMIDWCRTDL AKTLKVPVEN VRIISPYIGG 

       250        260        270        280        290        300 
GFGGKLFLRS DALLAALAAR AVKRPVKVML PRPSIPNNTT HRPATLQHLR IGADQSGKIT 

       310        320        330        340        350        360 
AISHESWSGN LPGGTPETAV QQSELLYAGA NRHTGLRLAT LDLPEGNAMR APGEAPGLMA 

       370        380        390        400        410        420 
LEIAIDELAE KAGIDPVEFR ILNDTQIDPA DPTRRFSRRQ LIECLRTGAD KFGWKQRNAT 

       430        440        450        460        470        480 
PGQVRDGEWL VGHGVAAGFR NNLLEKSGAR VHLEPNGTVT VETDMTDIGT GSYTILAQTA 

       490        500        510        520        530        540 
AEMLGVPLEQ VAVHLGDSSF PVSAGSGGQW GANTSTSGVY AACVKLREMI ASAVGFDPEQ 

       550        560        570        580        590        600 
SQFADGKITN GTRSAILHEA TAGGRLTAEE SIEFGTLSKE YQQSTFAGHF VEVGVHSATG 

       610        620        630        640        650        660 
EVRVRRMLAV CAAGRILNPK TARSQVIGAM TMGMGAALME ELAVDDRLGY FVNHDMAGYE 

       670        680        690        700        710        720 
VPVHADIPKQ EVIFLDDTDP ISSPMKAKGV GELGLCGVSA AIANAVYNAT GIRVRDYPIT 

       730 
LDKLLDKLPD VV 

« Hide

References

[1]"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7."
Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. expand/collapse author list , Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R.
Nature 409:529-533(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
[2]"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. expand/collapse author list , Kuhara S., Shiba T., Hattori M., Shinagawa H.
DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005174 Genomic DNA. Translation: AAG54609.1.
BA000007 Genomic DNA. Translation: BAB33737.1.
PIRB90668.
E85518.
RefSeqNP_286001.1. NC_002655.2.
NP_308341.1. NC_002695.1.

3D structure databases

ProteinModelPortalQ8X6J4.
SMRQ8X6J4. Positions 17-731.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING155864.Z0350.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG54609; AAG54609; Z0350.
BAB33737; BAB33737; BAB33737.
GeneID914413.
957138.
KEGGece:Z0350.
ecs:ECs0314.
PATRIC18349570. VBIEscCol44059_0307.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1529.
HOGENOMHOG000244716.
KOK11177.
OMATHNLGEC.
OrthoDBEOG6ZSP3F.

Enzyme and pathway databases

BioCycECOL386585:GJFA-314-MONOMER.
ECOO157:YAGR-MONOMER.

Family and domain databases

Gene3D3.30.365.10. 6 hits.
3.90.1170.50. 1 hit.
InterProIPR000674. Ald_Oxase/Xan_DH_a/b.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
[Graphical view]
PfamPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
[Graphical view]
SMARTSM01008. Ald_Xan_dh_C. 1 hit.
[Graphical view]
SUPFAMSSF54665. SSF54665. 1 hit.
SSF56003. SSF56003. 1 hit.
ProtoNetSearch...

Entry information

Entry nameYAGR_ECO57
AccessionPrimary (citable) accession number: Q8X6J4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families