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Q8X6J4

- YAGR_ECO57

UniProt

Q8X6J4 - YAGR_ECO57

Protein

Putative xanthine dehydrogenase YagR molybdenum-binding subunit

Gene

yagR

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Xanthine + NAD+ + H2O = urate + NADH.
    Hypoxanthine + NAD+ + H2O = xanthine + NADH.

    Cofactori

    Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi211 – 2111MolybdenumSequence Analysis
    Metal bindingi242 – 2421Molybdenum; via carbonyl oxygenSequence Analysis
    Metal bindingi350 – 3501Molybdenum; via amide nitrogenSequence Analysis

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. xanthine dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. purine nucleobase metabolic process Source: UniProtKB-KW
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Purine metabolism, Purine salvage

    Keywords - Ligandi

    Metal-binding, Molybdenum, NAD

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-314-MONOMER.
    ECOO157:YAGR-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative xanthine dehydrogenase YagR molybdenum-binding subunit (EC:1.17.1.4)
    Gene namesi
    Name:yagR
    Ordered Locus Names:Z0350, ECs0314
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 732732Putative xanthine dehydrogenase YagR molybdenum-binding subunitPRO_0000166091Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotrimer of YagR, YagS and YagT.Curated

    Protein-protein interaction databases

    STRINGi155864.Z0350.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8X6J4.
    SMRiQ8X6J4. Positions 17-731.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xanthine dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1529.
    HOGENOMiHOG000244716.
    KOiK11177.
    OMAiTHNLGEC.
    OrthoDBiEOG6ZSP3F.

    Family and domain databases

    Gene3Di3.30.365.10. 6 hits.
    3.90.1170.50. 1 hit.
    InterProiIPR000674. Ald_Oxase/Xan_DH_a/b.
    IPR008274. AldOxase/xan_DH_Mopterin-bd.
    [Graphical view]
    PfamiPF01315. Ald_Xan_dh_C. 1 hit.
    PF02738. Ald_Xan_dh_C2. 1 hit.
    [Graphical view]
    SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54665. SSF54665. 1 hit.
    SSF56003. SSF56003. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8X6J4-1 [UniParc]FASTAAdd to Basket

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    MKFDKPAGEN PIDQLKVVGR PHDRIDGPLK TTGTARYAYE WHEESPNAAY    50
    GYIVGSAIAK GRLTALDTDA AQKAPGVLPV ITASNAGALS KGDKNTARLL 100
    GGPTIEHYHQ AIALVVAETF EQARAAASLV QAHYRRNKGA YSLADEKQAV 150
    SQPPEDTPDK NVGDFDGAFS SAAVKIDATY TTPDQSHMAM EPHASMAVWD 200
    GNKLTLWTSN QMIDWCRTDL AKTLKVPVEN VRIISPYIGG GFGGKLFLRS 250
    DALLAALAAR AVKRPVKVML PRPSIPNNTT HRPATLQHLR IGADQSGKIT 300
    AISHESWSGN LPGGTPETAV QQSELLYAGA NRHTGLRLAT LDLPEGNAMR 350
    APGEAPGLMA LEIAIDELAE KAGIDPVEFR ILNDTQIDPA DPTRRFSRRQ 400
    LIECLRTGAD KFGWKQRNAT PGQVRDGEWL VGHGVAAGFR NNLLEKSGAR 450
    VHLEPNGTVT VETDMTDIGT GSYTILAQTA AEMLGVPLEQ VAVHLGDSSF 500
    PVSAGSGGQW GANTSTSGVY AACVKLREMI ASAVGFDPEQ SQFADGKITN 550
    GTRSAILHEA TAGGRLTAEE SIEFGTLSKE YQQSTFAGHF VEVGVHSATG 600
    EVRVRRMLAV CAAGRILNPK TARSQVIGAM TMGMGAALME ELAVDDRLGY 650
    FVNHDMAGYE VPVHADIPKQ EVIFLDDTDP ISSPMKAKGV GELGLCGVSA 700
    AIANAVYNAT GIRVRDYPIT LDKLLDKLPD VV 732
    Length:732
    Mass (Da):78,135
    Last modified:March 1, 2002 - v1
    Checksum:iA996E91BEB2643F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG54609.1.
    BA000007 Genomic DNA. Translation: BAB33737.1.
    PIRiB90668.
    E85518.
    RefSeqiNP_286001.1. NC_002655.2.
    NP_308341.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG54609; AAG54609; Z0350.
    BAB33737; BAB33737; BAB33737.
    GeneIDi914413.
    957138.
    KEGGiece:Z0350.
    ecs:ECs0314.
    PATRICi18349570. VBIEscCol44059_0307.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG54609.1 .
    BA000007 Genomic DNA. Translation: BAB33737.1 .
    PIRi B90668.
    E85518.
    RefSeqi NP_286001.1. NC_002655.2.
    NP_308341.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali Q8X6J4.
    SMRi Q8X6J4. Positions 17-731.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z0350.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG54609 ; AAG54609 ; Z0350 .
    BAB33737 ; BAB33737 ; BAB33737 .
    GeneIDi 914413.
    957138.
    KEGGi ece:Z0350.
    ecs:ECs0314.
    PATRICi 18349570. VBIEscCol44059_0307.

    Phylogenomic databases

    eggNOGi COG1529.
    HOGENOMi HOG000244716.
    KOi K11177.
    OMAi THNLGEC.
    OrthoDBi EOG6ZSP3F.

    Enzyme and pathway databases

    BioCyci ECOL386585:GJFA-314-MONOMER.
    ECOO157:YAGR-MONOMER.

    Family and domain databases

    Gene3Di 3.30.365.10. 6 hits.
    3.90.1170.50. 1 hit.
    InterProi IPR000674. Ald_Oxase/Xan_DH_a/b.
    IPR008274. AldOxase/xan_DH_Mopterin-bd.
    [Graphical view ]
    Pfami PF01315. Ald_Xan_dh_C. 1 hit.
    PF02738. Ald_Xan_dh_C2. 1 hit.
    [Graphical view ]
    SMARTi SM01008. Ald_Xan_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54665. SSF54665. 1 hit.
    SSF56003. SSF56003. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiYAGR_ECO57
    AccessioniPrimary (citable) accession number: Q8X6J4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3