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Q8X6J0

- YAGS_ECO57

UniProt

Q8X6J0 - YAGS_ECO57

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Protein

Putative xanthine dehydrogenase YagS FAD-binding subunit

Gene
yagS, Z0351, ECs0315
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

FAD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei212 – 2121FAD; via amide nitrogen and carbonyl oxygen Reviewed prediction
Binding sitei227 – 2271FAD Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 338FAD Reviewed prediction
Nucleotide bindingi107 – 1115FAD Reviewed prediction

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
  3. xanthine dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. purine nucleobase metabolic process Source: UniProtKB-KW
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism, Purine salvage

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciECOL386585:GJFA-315-MONOMER.
ECOO157:YAGS-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative xanthine dehydrogenase YagS FAD-binding subunit (EC:1.17.1.4)
Gene namesi
Name:yagS
Ordered Locus Names:Z0351, ECs0315
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Putative xanthine dehydrogenase YagS FAD-binding subunitPRO_0000166095Add
BLAST

Proteomic databases

PRIDEiQ8X6J0.

Interactioni

Subunit structurei

Heterotrimer of YagR, YagS and YagT Reviewed prediction.

Protein-protein interaction databases

STRINGi155864.Z0351.

Structurei

3D structure databases

ProteinModelPortaliQ8X6J0.
SMRiQ8X6J0. Positions 1-318.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 223223FAD-binding PCMH-typeAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1319.
HOGENOMiHOG000244727.
KOiK11178.
OMAiPCNKRRP.
OrthoDBiEOG66TG3V.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 2 hits.
InterProiIPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
[Graphical view]
PfamiPF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
[Graphical view]
SMARTiSM01092. CO_deh_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF55447. SSF55447. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X6J0-1 [UniParc]FASTAAdd to Basket

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MKAFTYERVN TPAEAALSAQ RVPGAKFIAG GTNLLDLMKL EIETPTHLID    50
VNGLGLDKIE VTDAGGLRIG ALVRNTDLVA HERVRRDYAV LSRALLAGAS 100
GQLRNQATTA GNLLQRTRCP YFYDTNQPCN KRLPGSGCAA LEGFSRQHAV 150
VGVSEACIAT HPSDMAVAMR LLDAVVETIT PEGKTRSITL ADFYHPPGKT 200
PHIETALLPG ELIVAVTLPP PLGGKHIYRK VRDRASYTFA LVSVAAIIQP 250
DGSGRVALGG VAHKPWRIEA ADAQLSQGAQ AVYDALFASA HPTAENTFKL 300
LLAKRTLASV LAEARAQA 318
Length:318
Mass (Da):33,886
Last modified:March 1, 2002 - v1
Checksum:i32C48CE9D0F16F90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG54610.1.
BA000007 Genomic DNA. Translation: BAB33738.1.
PIRiC90668.
F85518.
RefSeqiNP_286002.1. NC_002655.2.
NP_308342.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG54610; AAG54610; Z0351.
BAB33738; BAB33738; BAB33738.
GeneIDi914414.
957139.
KEGGiece:Z0351.
ecs:ECs0315.
PATRICi18349572. VBIEscCol44059_0308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG54610.1 .
BA000007 Genomic DNA. Translation: BAB33738.1 .
PIRi C90668.
F85518.
RefSeqi NP_286002.1. NC_002655.2.
NP_308342.1. NC_002695.1.

3D structure databases

ProteinModelPortali Q8X6J0.
SMRi Q8X6J0. Positions 1-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z0351.

Proteomic databases

PRIDEi Q8X6J0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG54610 ; AAG54610 ; Z0351 .
BAB33738 ; BAB33738 ; BAB33738 .
GeneIDi 914414.
957139.
KEGGi ece:Z0351.
ecs:ECs0315.
PATRICi 18349572. VBIEscCol44059_0308.

Phylogenomic databases

eggNOGi COG1319.
HOGENOMi HOG000244727.
KOi K11178.
OMAi PCNKRRP.
OrthoDBi EOG66TG3V.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-315-MONOMER.
ECOO157:YAGS-MONOMER.

Family and domain databases

Gene3Di 3.30.43.10. 1 hit.
3.30.465.10. 2 hits.
InterProi IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
[Graphical view ]
Pfami PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
[Graphical view ]
SMARTi SM01092. CO_deh_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55447. SSF55447. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEi PS51387. FAD_PCMH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiYAGS_ECO57
AccessioniPrimary (citable) accession number: Q8X6J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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