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Protein

Putative xanthine dehydrogenase YagS FAD-binding subunit

Gene

yagS

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei212FAD; via amide nitrogen and carbonyl oxygenSequence analysis1
Binding sitei227FADSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 33FADSequence analysis8
Nucleotide bindingi107 – 111FADSequence analysis5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPurine metabolism, Purine salvage
LigandFAD, Flavoprotein, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative xanthine dehydrogenase YagS FAD-binding subunit (EC:1.17.1.4)
Gene namesi
Name:yagS
Ordered Locus Names:Z0351, ECs0315
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001660951 – 318Putative xanthine dehydrogenase YagS FAD-binding subunitAdd BLAST318

Proteomic databases

PRIDEiQ8X6J0.

Interactioni

Subunit structurei

Heterotrimer of YagR, YagS and YagT.Curated

Protein-protein interaction databases

STRINGi155864.Z0351.

Structurei

3D structure databases

ProteinModelPortaliQ8X6J0.
SMRiQ8X6J0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 223FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST223

Phylogenomic databases

eggNOGiENOG4105DIP. Bacteria.
COG1319. LUCA.
HOGENOMiHOG000244727.
KOiK11178.
OMAiGGTHIYR.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 2 hits.
InterProiView protein in InterPro
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
PfamiView protein in Pfam
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
SMARTiView protein in SMART
SM01092. CO_deh_flav_C. 1 hit.
SUPFAMiSSF55447. SSF55447. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEiView protein in PROSITE
PS51387. FAD_PCMH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8X6J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAFTYERVN TPAEAALSAQ RVPGAKFIAG GTNLLDLMKL EIETPTHLID
60 70 80 90 100
VNGLGLDKIE VTDAGGLRIG ALVRNTDLVA HERVRRDYAV LSRALLAGAS
110 120 130 140 150
GQLRNQATTA GNLLQRTRCP YFYDTNQPCN KRLPGSGCAA LEGFSRQHAV
160 170 180 190 200
VGVSEACIAT HPSDMAVAMR LLDAVVETIT PEGKTRSITL ADFYHPPGKT
210 220 230 240 250
PHIETALLPG ELIVAVTLPP PLGGKHIYRK VRDRASYTFA LVSVAAIIQP
260 270 280 290 300
DGSGRVALGG VAHKPWRIEA ADAQLSQGAQ AVYDALFASA HPTAENTFKL
310
LLAKRTLASV LAEARAQA
Length:318
Mass (Da):33,886
Last modified:March 1, 2002 - v1
Checksum:i32C48CE9D0F16F90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG54610.1.
BA000007 Genomic DNA. Translation: BAB33738.1.
PIRiC90668.
F85518.
RefSeqiNP_308342.1. NC_002695.1.
WP_000643341.1. NZ_LPWC02000002.1.

Genome annotation databases

EnsemblBacteriaiAAG54610; AAG54610; Z0351.
BAB33738; BAB33738; BAB33738.
GeneIDi914414.
KEGGiece:Z0351.
ecs:ECs0315.
PATRICi18349572. VBIEscCol44059_0308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG54610.1.
BA000007 Genomic DNA. Translation: BAB33738.1.
PIRiC90668.
F85518.
RefSeqiNP_308342.1. NC_002695.1.
WP_000643341.1. NZ_LPWC02000002.1.

3D structure databases

ProteinModelPortaliQ8X6J0.
SMRiQ8X6J0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z0351.

Proteomic databases

PRIDEiQ8X6J0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG54610; AAG54610; Z0351.
BAB33738; BAB33738; BAB33738.
GeneIDi914414.
KEGGiece:Z0351.
ecs:ECs0315.
PATRICi18349572. VBIEscCol44059_0308.

Phylogenomic databases

eggNOGiENOG4105DIP. Bacteria.
COG1319. LUCA.
HOGENOMiHOG000244727.
KOiK11178.
OMAiGGTHIYR.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 2 hits.
InterProiView protein in InterPro
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
PfamiView protein in Pfam
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
SMARTiView protein in SMART
SM01092. CO_deh_flav_C. 1 hit.
SUPFAMiSSF55447. SSF55447. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEiView protein in PROSITE
PS51387. FAD_PCMH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYAGS_ECO57
AccessioniPrimary (citable) accession number: Q8X6J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: February 15, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.