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Protein

Putative xanthine dehydrogenase YagS FAD-binding subunit

Gene

yagS

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei212FAD; via amide nitrogen and carbonyl oxygenSequence analysis1
Binding sitei227FADSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 33FADSequence analysis8
Nucleotide bindingi107 – 111FADSequence analysis5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPurine metabolism, Purine salvage
LigandFAD, Flavoprotein, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative xanthine dehydrogenase YagS FAD-binding subunit (EC:1.17.1.4)
Gene namesi
Name:yagS
Ordered Locus Names:Z0351, ECs0315
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001660951 – 318Putative xanthine dehydrogenase YagS FAD-binding subunitAdd BLAST318

Proteomic databases

PRIDEiQ8X6J0

Interactioni

Subunit structurei

Heterotrimer of YagR, YagS and YagT.Curated

Protein-protein interaction databases

STRINGi155864.Z0351

Structurei

3D structure databases

ProteinModelPortaliQ8X6J0
SMRiQ8X6J0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 223FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST223

Phylogenomic databases

eggNOGiENOG4105DIP Bacteria
COG1319 LUCA
HOGENOMiHOG000244727
KOiK11178
OMAiAFTYERA

Family and domain databases

InterProiView protein in InterPro
IPR005107 CO_DH_flav_C
IPR036683 CO_DH_flav_C_dom_sf
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR002346 Mopterin_DH_FAD-bd
PfamiView protein in Pfam
PF03450 CO_deh_flav_C, 1 hit
PF00941 FAD_binding_5, 1 hit
SMARTiView protein in SMART
SM01092 CO_deh_flav_C, 1 hit
SUPFAMiSSF55447 SSF55447, 1 hit
SSF56176 SSF56176, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8X6J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAFTYERVN TPAEAALSAQ RVPGAKFIAG GTNLLDLMKL EIETPTHLID
60 70 80 90 100
VNGLGLDKIE VTDAGGLRIG ALVRNTDLVA HERVRRDYAV LSRALLAGAS
110 120 130 140 150
GQLRNQATTA GNLLQRTRCP YFYDTNQPCN KRLPGSGCAA LEGFSRQHAV
160 170 180 190 200
VGVSEACIAT HPSDMAVAMR LLDAVVETIT PEGKTRSITL ADFYHPPGKT
210 220 230 240 250
PHIETALLPG ELIVAVTLPP PLGGKHIYRK VRDRASYTFA LVSVAAIIQP
260 270 280 290 300
DGSGRVALGG VAHKPWRIEA ADAQLSQGAQ AVYDALFASA HPTAENTFKL
310
LLAKRTLASV LAEARAQA
Length:318
Mass (Da):33,886
Last modified:March 1, 2002 - v1
Checksum:i32C48CE9D0F16F90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG54610.1
BA000007 Genomic DNA Translation: BAB33738.1
PIRiC90668
F85518
RefSeqiNP_308342.1, NC_002695.1
WP_000643341.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG54610; AAG54610; Z0351
BAB33738; BAB33738; BAB33738
GeneIDi914414
KEGGiece:Z0351
ecs:ECs0315
PATRICifig|386585.9.peg.409

Similar proteinsi

Entry informationi

Entry nameiYAGS_ECO57
AccessioniPrimary (citable) accession number: Q8X6J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health