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Q8X6J0

- YAGS_ECO57

UniProt

Q8X6J0 - YAGS_ECO57

Protein

Putative xanthine dehydrogenase YagS FAD-binding subunit

Gene

yagS

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Xanthine + NAD+ + H2O = urate + NADH.
    Hypoxanthine + NAD+ + H2O = xanthine + NADH.

    Cofactori

    FAD.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei212 – 2121FAD; via amide nitrogen and carbonyl oxygenSequence Analysis
    Binding sitei227 – 2271FADSequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 338FADSequence Analysis
    Nucleotide bindingi107 – 1115FADSequence Analysis

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
    3. xanthine dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. purine nucleobase metabolic process Source: UniProtKB-KW
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Purine metabolism, Purine salvage

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-315-MONOMER.
    ECOO157:YAGS-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative xanthine dehydrogenase YagS FAD-binding subunit (EC:1.17.1.4)
    Gene namesi
    Name:yagS
    Ordered Locus Names:Z0351, ECs0315
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Putative xanthine dehydrogenase YagS FAD-binding subunitPRO_0000166095Add
    BLAST

    Proteomic databases

    PRIDEiQ8X6J0.

    Interactioni

    Subunit structurei

    Heterotrimer of YagR, YagS and YagT.Curated

    Protein-protein interaction databases

    STRINGi155864.Z0351.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8X6J0.
    SMRiQ8X6J0. Positions 1-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 223223FAD-binding PCMH-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1319.
    HOGENOMiHOG000244727.
    KOiK11178.
    OMAiPCNKRRP.
    OrthoDBiEOG66TG3V.

    Family and domain databases

    Gene3Di3.30.43.10. 1 hit.
    3.30.465.10. 2 hits.
    InterProiIPR005107. CO_DH_flav_C.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR002346. Mopterin_DH_FAD-bd.
    [Graphical view]
    PfamiPF03450. CO_deh_flav_C. 1 hit.
    PF00941. FAD_binding_5. 1 hit.
    [Graphical view]
    SMARTiSM01092. CO_deh_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55447. SSF55447. 1 hit.
    SSF56176. SSF56176. 1 hit.
    PROSITEiPS51387. FAD_PCMH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8X6J0-1 [UniParc]FASTAAdd to Basket

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    MKAFTYERVN TPAEAALSAQ RVPGAKFIAG GTNLLDLMKL EIETPTHLID    50
    VNGLGLDKIE VTDAGGLRIG ALVRNTDLVA HERVRRDYAV LSRALLAGAS 100
    GQLRNQATTA GNLLQRTRCP YFYDTNQPCN KRLPGSGCAA LEGFSRQHAV 150
    VGVSEACIAT HPSDMAVAMR LLDAVVETIT PEGKTRSITL ADFYHPPGKT 200
    PHIETALLPG ELIVAVTLPP PLGGKHIYRK VRDRASYTFA LVSVAAIIQP 250
    DGSGRVALGG VAHKPWRIEA ADAQLSQGAQ AVYDALFASA HPTAENTFKL 300
    LLAKRTLASV LAEARAQA 318
    Length:318
    Mass (Da):33,886
    Last modified:March 1, 2002 - v1
    Checksum:i32C48CE9D0F16F90
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG54610.1.
    BA000007 Genomic DNA. Translation: BAB33738.1.
    PIRiC90668.
    F85518.
    RefSeqiNP_286002.1. NC_002655.2.
    NP_308342.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG54610; AAG54610; Z0351.
    BAB33738; BAB33738; BAB33738.
    GeneIDi914414.
    957139.
    KEGGiece:Z0351.
    ecs:ECs0315.
    PATRICi18349572. VBIEscCol44059_0308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG54610.1 .
    BA000007 Genomic DNA. Translation: BAB33738.1 .
    PIRi C90668.
    F85518.
    RefSeqi NP_286002.1. NC_002655.2.
    NP_308342.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali Q8X6J0.
    SMRi Q8X6J0. Positions 1-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z0351.

    Proteomic databases

    PRIDEi Q8X6J0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG54610 ; AAG54610 ; Z0351 .
    BAB33738 ; BAB33738 ; BAB33738 .
    GeneIDi 914414.
    957139.
    KEGGi ece:Z0351.
    ecs:ECs0315.
    PATRICi 18349572. VBIEscCol44059_0308.

    Phylogenomic databases

    eggNOGi COG1319.
    HOGENOMi HOG000244727.
    KOi K11178.
    OMAi PCNKRRP.
    OrthoDBi EOG66TG3V.

    Enzyme and pathway databases

    BioCyci ECOL386585:GJFA-315-MONOMER.
    ECOO157:YAGS-MONOMER.

    Family and domain databases

    Gene3Di 3.30.43.10. 1 hit.
    3.30.465.10. 2 hits.
    InterProi IPR005107. CO_DH_flav_C.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR002346. Mopterin_DH_FAD-bd.
    [Graphical view ]
    Pfami PF03450. CO_deh_flav_C. 1 hit.
    PF00941. FAD_binding_5. 1 hit.
    [Graphical view ]
    SMARTi SM01092. CO_deh_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55447. SSF55447. 1 hit.
    SSF56176. SSF56176. 1 hit.
    PROSITEi PS51387. FAD_PCMH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiYAGS_ECO57
    AccessioniPrimary (citable) accession number: Q8X6J0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3