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Protein

Xanthine dehydrogenase molybdenum-binding subunit

Gene

xdhA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) (By similarity).By similarity

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

Mo-molybdopterinBy similarityNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

Pathwayi: hypoxanthine degradation

This protein is involved in step 1 and 2 of the subpathway that synthesizes urate from hypoxanthine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Xanthine dehydrogenase iron-sulfur-binding subunit (xdhC), Xanthine dehydrogenase FAD-binding subunit (xdhB), Xanthine dehydrogenase molybdenum-binding subunit (xdhA)
  2. Xanthine dehydrogenase FAD-binding subunit (xdhB), Xanthine dehydrogenase molybdenum-binding subunit (xdhA)
This subpathway is part of the pathway hypoxanthine degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes urate from hypoxanthine, the pathway hypoxanthine degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi206MolybdenumBy similarity1
Metal bindingi237Molybdenum; via carbonyl oxygenBy similarity1
Metal bindingi350Molybdenum; via amide nitrogenBy similarity1
Metal bindingi516Molybdenum; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPurine metabolism, Purine salvage
LigandMetal-binding, Molybdenum, NAD

Enzyme and pathway databases

UniPathwayiUPA00604; UER00661
UPA00604; UER00662

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine dehydrogenase molybdenum-binding subunit (EC:1.17.1.4)
Gene namesi
Name:xdhA
Ordered Locus Names:Z4205, ECs3739
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001660891 – 752Xanthine dehydrogenase molybdenum-binding subunitAdd BLAST752

Proteomic databases

PRIDEiQ8X6C7

Interactioni

Subunit structurei

Heterotrimer of XdhA, XdhB and XdhC.Curated

Protein-protein interaction databases

STRINGi155864.Z4205

Structurei

3D structure databases

ProteinModelPortaliQ8X6C7
SMRiQ8X6C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xanthine dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105C7W Bacteria
COG1529 LUCA
HOGENOMiHOG000244715
KOiK00087
OMAiPYNPVAP

Family and domain databases

InterProiView protein in InterPro
IPR000674 Ald_Oxase/Xan_DH_a/b
IPR036856 Ald_Oxase/Xan_DH_a/b_sf
IPR008274 AldOxase/xan_DH_Mopterin-bd
IPR037165 AldOxase/xan_DH_Mopterin-bd_sf
PfamiView protein in Pfam
PF01315 Ald_Xan_dh_C, 1 hit
PF02738 Ald_Xan_dh_C2, 1 hit
SMARTiView protein in SMART
SM01008 Ald_Xan_dh_C, 1 hit
SUPFAMiSSF54665 SSF54665, 1 hit
SSF56003 SSF56003, 1 hit

Sequencei

Sequence statusi: Complete.

Q8X6C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVDAIAKVT GRARYTDDYV MAGMCYAKYV RSPIAHGYAV SINDEQARSL
60 70 80 90 100
PGVLAIFTWE DVPDIPFATA GHAWTLDENK RDTADRALLT RHVRHHGDAV
110 120 130 140 150
AIVVARDELT AEKAAQLVSI EWEELPVITT PEAALAEDAA PIHNGGNLLK
160 170 180 190 200
QSTMSTGNVQ QTIDAADYQV QGHYQTPVIQ HCHMESVTSL AWMEDDSRIT
210 220 230 240 250
IVSSTQIPHI VRRVVGQALD IPWSCVRVIK TFVGGGFGNK QDVLEEPMAA
260 270 280 290 300
FLTSKLGGIP VKVSLSREEC FLATRTRHAF TIDGQMGVNR DGTLKGYSLD
310 320 330 340 350
VLSNTGAYVS HGHSIASAGG NKVAYLYPRC AYAYSSKTCY TNLPSAGAMR
360 370 380 390 400
GYGAPQVVFA VESMLDDAAT ALGIDPVEIR LRNASREGDA NPLTGKRIYS
410 420 430 440 450
AGLPECLEKG RKIFEWEKRR AECQNQQGNL RRGVGVACFS YTSNTWPVGV
460 470 480 490 500
EIAGARLLMN QDGTINVQSG ATEIGQGADT VFSQMVAETV GVPVSDVRVI
510 520 530 540 550
STQDTDVTPF DPGAFASRQS YVAAPALRSA ALLLKEKIIA HAAVMLHQSA
560 570 580 590 600
MNLTLIKGHI VLVERPEEPL MSLKDLAMDA FYHPERGGQL SAESSIKTTT
610 620 630 640 650
NPPAFGCTFV DLTVDIALCK VTINRILNVH DSGHILNPLL AEGQVHGGMG
660 670 680 690 700
MGIGWALFEE MIIDAKSGVV RNPNLLDYKM PTMPDLPQLE SAFVEINEPQ
710 720 730 740 750
SAYGHKSLGE PPIIPVAAAI RNAVKMATGV AINTLPLTPK RLYEEFHLAG

LI
Length:752
Mass (Da):81,370
Last modified:March 1, 2002 - v1
Checksum:iC42D8B8B7B386BB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG57995.1
BA000007 Genomic DNA Translation: BAB37162.1
PIRiC91096
G85941
RefSeqiNP_311766.1, NC_002695.1

Genome annotation databases

EnsemblBacteriaiAAG57995; AAG57995; Z4205
BAB37162; BAB37162; BAB37162
GeneIDi916443
KEGGiece:Z4205
ecs:ECs3739
PATRICifig|386585.9.peg.3901

Similar proteinsi

Entry informationi

Entry nameiXDHA_ECO57
AccessioniPrimary (citable) accession number: Q8X6C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health