Reviewed,
UniProtKB/Swiss-Prot Q8X6C7 (XDHA_ECO57)
Last modified
January 19, 2010.
Version 50.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Xanthine dehydrogenase molybdenum-binding subunit EC=1.17.1.4 | ||||
| Gene names |
| ||||
| Organism | Escherichia coli O157:H7 [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83334 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 752 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) By similarity. |
| Catalytic activity | Xanthine + NAD+ + H2O = urate + NADH. Hypoxanthine + NAD+ + H2O = xanthine + NADH. |
| Cofactor | Binds 1 molybdenum ion (molybdopterin) per subunit By similarity. |
| Pathway | Purine metabolism; hypoxanthine degradation; urate from hypoxanthine: step 1/2. Purine metabolism; hypoxanthine degradation; urate from hypoxanthine: step 2/2. |
| Subunit structure | Heterotrimer of xdhA, xdhB and xdhC Probable. |
| Sequence similarities | Belongs to the xanthine dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine metabolism Purine salvage |
| Ligand | Metal-binding Molybdenum NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW purine base metabolic processInferred from electronic annotation. Source: UniProtKB-KW purine ribonucleoside salvageInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | molybdenum ion binding Inferred from electronic annotation. Source: UniProtKB-KW xanthine dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 752 | 752 | Xanthine dehydrogenase molybdenum-binding subunit | PRO_0000166089 | |||||
Sites | |||||||||
| Metal binding | 206 | 1 | Molybdenum By similarity | ||||||
| Metal binding | 237 | 1 | Molybdenum; via carbonyl oxygen By similarity | ||||||
| Metal binding | 350 | 1 | Molybdenum; via amide nitrogen By similarity | ||||||
| Metal binding | 516 | 1 | Molybdenum; via amide nitrogen By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. Blattner F.R.Nature 409:529-533(2001) [PubMed: 11206551] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC. |
| [2] | "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. Shinagawa H.DNA Res. 8:11-22(2001) [PubMed: 11258796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE005174 Genomic DNA. Translation: AAG57995.1. BA000007 Genomic DNA. Translation: BAB37162.1. |
| PIR | C91096. G85941. |
| RefSeq | NP_289436.1. NP_311766.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 916443. 958353. |
| GenomeReviews | Gene locus Z4205 in contig AE005174_GR. Gene locus ECs3739 in contig BA000007_GR. |
| KEGG | ece:Z4205. ecs:ECs3739. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG705921. |
| OMA | YTNTVPA. |
Enzyme and pathway databases | |
| BioCyc | ECOL83334:ECS3739-MONOMER. |
Family and domain databases | |
| InterPro | IPR000674. Ald_Oxase/Xan_DH_a/b. IPR008274. AldOxase/xan_DH_Mopterin-bd. [Graphical view] |
| Gene3D | G3DSA:3.30.365.10. Ald_xan_DH_mo_bd. 2 hits. G3DSA:3.90.1170.50. Aldxan_DH_hamm. 1 hit. |
| Pfam | PF01315. Ald_Xan_dh_C. 1 hit. PF02738. Ald_Xan_dh_C2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | XDHA_ECO57 | ||||||||
| Accession | Primary (citable) accession number: Q8X6C7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


