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Q8X6C7

- XDHA_ECO57

UniProt

Q8X6C7 - XDHA_ECO57

Protein

Xanthine dehydrogenase molybdenum-binding subunit

Gene

xdhA

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) By similarity.By similarity

    Catalytic activityi

    Xanthine + NAD+ + H2O = urate + NADH.
    Hypoxanthine + NAD+ + H2O = xanthine + NADH.

    Cofactori

    Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi206 – 2061MolybdenumBy similarity
    Metal bindingi237 – 2371Molybdenum; via carbonyl oxygenBy similarity
    Metal bindingi350 – 3501Molybdenum; via amide nitrogenBy similarity
    Metal bindingi516 – 5161Molybdenum; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. xanthine dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. hypoxanthine catabolic process Source: UniProtKB-UniPathway
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Purine metabolism, Purine salvage

    Keywords - Ligandi

    Metal-binding, Molybdenum, NAD

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-3706-MONOMER.
    ECOO157:Z4205-MONOMER.
    UniPathwayiUPA00604; UER00661.
    UPA00604; UER00662.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xanthine dehydrogenase molybdenum-binding subunit (EC:1.17.1.4)
    Gene namesi
    Name:xdhA
    Ordered Locus Names:Z4205, ECs3739
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 752752Xanthine dehydrogenase molybdenum-binding subunitPRO_0000166089Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotrimer of XdhA, XdhB and XdhC.Curated

    Protein-protein interaction databases

    STRINGi155864.Z4205.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8X6C7.
    SMRiQ8X6C7. Positions 1-750.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xanthine dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1529.
    HOGENOMiHOG000244715.
    KOiK00087.
    OMAiAYVSHGH.
    OrthoDBiEOG6ZSP3F.

    Family and domain databases

    Gene3Di3.30.365.10. 6 hits.
    3.90.1170.50. 1 hit.
    InterProiIPR000674. Ald_Oxase/Xan_DH_a/b.
    IPR008274. AldOxase/xan_DH_Mopterin-bd.
    [Graphical view]
    PfamiPF01315. Ald_Xan_dh_C. 1 hit.
    PF02738. Ald_Xan_dh_C2. 1 hit.
    [Graphical view]
    SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54665. SSF54665. 1 hit.
    SSF56003. SSF56003. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8X6C7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVDAIAKVT GRARYTDDYV MAGMCYAKYV RSPIAHGYAV SINDEQARSL    50
    PGVLAIFTWE DVPDIPFATA GHAWTLDENK RDTADRALLT RHVRHHGDAV 100
    AIVVARDELT AEKAAQLVSI EWEELPVITT PEAALAEDAA PIHNGGNLLK 150
    QSTMSTGNVQ QTIDAADYQV QGHYQTPVIQ HCHMESVTSL AWMEDDSRIT 200
    IVSSTQIPHI VRRVVGQALD IPWSCVRVIK TFVGGGFGNK QDVLEEPMAA 250
    FLTSKLGGIP VKVSLSREEC FLATRTRHAF TIDGQMGVNR DGTLKGYSLD 300
    VLSNTGAYVS HGHSIASAGG NKVAYLYPRC AYAYSSKTCY TNLPSAGAMR 350
    GYGAPQVVFA VESMLDDAAT ALGIDPVEIR LRNASREGDA NPLTGKRIYS 400
    AGLPECLEKG RKIFEWEKRR AECQNQQGNL RRGVGVACFS YTSNTWPVGV 450
    EIAGARLLMN QDGTINVQSG ATEIGQGADT VFSQMVAETV GVPVSDVRVI 500
    STQDTDVTPF DPGAFASRQS YVAAPALRSA ALLLKEKIIA HAAVMLHQSA 550
    MNLTLIKGHI VLVERPEEPL MSLKDLAMDA FYHPERGGQL SAESSIKTTT 600
    NPPAFGCTFV DLTVDIALCK VTINRILNVH DSGHILNPLL AEGQVHGGMG 650
    MGIGWALFEE MIIDAKSGVV RNPNLLDYKM PTMPDLPQLE SAFVEINEPQ 700
    SAYGHKSLGE PPIIPVAAAI RNAVKMATGV AINTLPLTPK RLYEEFHLAG 750
    LI 752
    Length:752
    Mass (Da):81,370
    Last modified:March 1, 2002 - v1
    Checksum:iC42D8B8B7B386BB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57995.1.
    BA000007 Genomic DNA. Translation: BAB37162.1.
    PIRiC91096.
    G85941.
    RefSeqiNP_289436.1. NC_002655.2.
    NP_311766.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG57995; AAG57995; Z4205.
    BAB37162; BAB37162; BAB37162.
    GeneIDi916443.
    958353.
    KEGGiece:Z4205.
    ecs:ECs3739.
    PATRICi18356959. VBIEscCol44059_3658.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57995.1 .
    BA000007 Genomic DNA. Translation: BAB37162.1 .
    PIRi C91096.
    G85941.
    RefSeqi NP_289436.1. NC_002655.2.
    NP_311766.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali Q8X6C7.
    SMRi Q8X6C7. Positions 1-750.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z4205.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG57995 ; AAG57995 ; Z4205 .
    BAB37162 ; BAB37162 ; BAB37162 .
    GeneIDi 916443.
    958353.
    KEGGi ece:Z4205.
    ecs:ECs3739.
    PATRICi 18356959. VBIEscCol44059_3658.

    Phylogenomic databases

    eggNOGi COG1529.
    HOGENOMi HOG000244715.
    KOi K00087.
    OMAi AYVSHGH.
    OrthoDBi EOG6ZSP3F.

    Enzyme and pathway databases

    UniPathwayi UPA00604 ; UER00661 .
    UPA00604 ; UER00662 .
    BioCyci ECOL386585:GJFA-3706-MONOMER.
    ECOO157:Z4205-MONOMER.

    Family and domain databases

    Gene3Di 3.30.365.10. 6 hits.
    3.90.1170.50. 1 hit.
    InterProi IPR000674. Ald_Oxase/Xan_DH_a/b.
    IPR008274. AldOxase/xan_DH_Mopterin-bd.
    [Graphical view ]
    Pfami PF01315. Ald_Xan_dh_C. 1 hit.
    PF02738. Ald_Xan_dh_C2. 1 hit.
    [Graphical view ]
    SMARTi SM01008. Ald_Xan_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54665. SSF54665. 1 hit.
    SSF56003. SSF56003. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiXDHA_ECO57
    AccessioniPrimary (citable) accession number: Q8X6C7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3