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Q8X6C7

- XDHA_ECO57

UniProt

Q8X6C7 - XDHA_ECO57

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Protein

Xanthine dehydrogenase molybdenum-binding subunit

Gene
xdhA, Z4205, ECs3739
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) By similarity.

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi206 – 2061Molybdenum By similarity
Metal bindingi237 – 2371Molybdenum; via carbonyl oxygen By similarity
Metal bindingi350 – 3501Molybdenum; via amide nitrogen By similarity
Metal bindingi516 – 5161Molybdenum; via amide nitrogen By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. xanthine dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. hypoxanthine catabolic process Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism, Purine salvage

Keywords - Ligandi

Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3706-MONOMER.
ECOO157:Z4205-MONOMER.
UniPathwayiUPA00604; UER00661.
UPA00604; UER00662.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine dehydrogenase molybdenum-binding subunit (EC:1.17.1.4)
Gene namesi
Name:xdhA
Ordered Locus Names:Z4205, ECs3739
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 752752Xanthine dehydrogenase molybdenum-binding subunitPRO_0000166089Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of XdhA, XdhB and XdhC Inferred.

Protein-protein interaction databases

STRINGi155864.Z4205.

Structurei

3D structure databases

ProteinModelPortaliQ8X6C7.
SMRiQ8X6C7. Positions 1-750.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1529.
HOGENOMiHOG000244715.
KOiK00087.
OMAiAYVSHGH.
OrthoDBiEOG6ZSP3F.

Family and domain databases

Gene3Di3.30.365.10. 6 hits.
3.90.1170.50. 1 hit.
InterProiIPR000674. Ald_Oxase/Xan_DH_a/b.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
[Graphical view]
PfamiPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
[Graphical view]
SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF54665. SSF54665. 1 hit.
SSF56003. SSF56003. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8X6C7-1 [UniParc]FASTAAdd to Basket

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MRVDAIAKVT GRARYTDDYV MAGMCYAKYV RSPIAHGYAV SINDEQARSL    50
PGVLAIFTWE DVPDIPFATA GHAWTLDENK RDTADRALLT RHVRHHGDAV 100
AIVVARDELT AEKAAQLVSI EWEELPVITT PEAALAEDAA PIHNGGNLLK 150
QSTMSTGNVQ QTIDAADYQV QGHYQTPVIQ HCHMESVTSL AWMEDDSRIT 200
IVSSTQIPHI VRRVVGQALD IPWSCVRVIK TFVGGGFGNK QDVLEEPMAA 250
FLTSKLGGIP VKVSLSREEC FLATRTRHAF TIDGQMGVNR DGTLKGYSLD 300
VLSNTGAYVS HGHSIASAGG NKVAYLYPRC AYAYSSKTCY TNLPSAGAMR 350
GYGAPQVVFA VESMLDDAAT ALGIDPVEIR LRNASREGDA NPLTGKRIYS 400
AGLPECLEKG RKIFEWEKRR AECQNQQGNL RRGVGVACFS YTSNTWPVGV 450
EIAGARLLMN QDGTINVQSG ATEIGQGADT VFSQMVAETV GVPVSDVRVI 500
STQDTDVTPF DPGAFASRQS YVAAPALRSA ALLLKEKIIA HAAVMLHQSA 550
MNLTLIKGHI VLVERPEEPL MSLKDLAMDA FYHPERGGQL SAESSIKTTT 600
NPPAFGCTFV DLTVDIALCK VTINRILNVH DSGHILNPLL AEGQVHGGMG 650
MGIGWALFEE MIIDAKSGVV RNPNLLDYKM PTMPDLPQLE SAFVEINEPQ 700
SAYGHKSLGE PPIIPVAAAI RNAVKMATGV AINTLPLTPK RLYEEFHLAG 750
LI 752
Length:752
Mass (Da):81,370
Last modified:March 1, 2002 - v1
Checksum:iC42D8B8B7B386BB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG57995.1.
BA000007 Genomic DNA. Translation: BAB37162.1.
PIRiC91096.
G85941.
RefSeqiNP_289436.1. NC_002655.2.
NP_311766.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG57995; AAG57995; Z4205.
BAB37162; BAB37162; BAB37162.
GeneIDi916443.
958353.
KEGGiece:Z4205.
ecs:ECs3739.
PATRICi18356959. VBIEscCol44059_3658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG57995.1 .
BA000007 Genomic DNA. Translation: BAB37162.1 .
PIRi C91096.
G85941.
RefSeqi NP_289436.1. NC_002655.2.
NP_311766.1. NC_002695.1.

3D structure databases

ProteinModelPortali Q8X6C7.
SMRi Q8X6C7. Positions 1-750.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z4205.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG57995 ; AAG57995 ; Z4205 .
BAB37162 ; BAB37162 ; BAB37162 .
GeneIDi 916443.
958353.
KEGGi ece:Z4205.
ecs:ECs3739.
PATRICi 18356959. VBIEscCol44059_3658.

Phylogenomic databases

eggNOGi COG1529.
HOGENOMi HOG000244715.
KOi K00087.
OMAi AYVSHGH.
OrthoDBi EOG6ZSP3F.

Enzyme and pathway databases

UniPathwayi UPA00604 ; UER00661 .
UPA00604 ; UER00662 .
BioCyci ECOL386585:GJFA-3706-MONOMER.
ECOO157:Z4205-MONOMER.

Family and domain databases

Gene3Di 3.30.365.10. 6 hits.
3.90.1170.50. 1 hit.
InterProi IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
[Graphical view ]
Pfami PF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
[Graphical view ]
SMARTi SM01008. Ald_Xan_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF54665. SSF54665. 1 hit.
SSF56003. SSF56003. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiXDHA_ECO57
AccessioniPrimary (citable) accession number: Q8X6C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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