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Q8X6C6

- BETA_ECO57

UniProt

Q8X6C6 - BETA_ECO57

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Protein
Oxygen-dependent choline dehydrogenase
Gene
betA, Z0398, ECs0357
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei473 – 4731 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FAD By similarity
Add
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciECOL386585:GJFA-354-MONOMER.
ECOO157:BETA-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:Z0398, ECs0357
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Oxygen-dependent choline dehydrogenaseUniRule annotation
PRO_0000205587Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z0398.

Structurei

3D structure databases

ProteinModelPortaliQ8X6C6.
SMRiQ8X6C6. Positions 1-531.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X6C6-1 [UniParc]FASTAAdd to Basket

« Hide

MQFDYIIIGA GSAGNVLATR LTEDPNTSVL LLEAGGPDYR FDFRTQMPAA    50
LAFPLQGKRY NWAYETEPEP FMNNRRMECG RGKGLGGSSL INGMCYIRGN 100
AMDLDNWAKE PGLENWSYLD CLPYYRKAET RDVGENDYHG GDGPVSVTTS 150
KPGVNPLFEA MIEAGVQAGY PRTDDLNGYQ QEGFGPMDRT VTPQGRRAST 200
ARGYLDQAKS RPNLTIRTHA MTDHIIFDCK RAVGVEWLEG DSTIPTRATA 250
NKEVLLCAGA IASPQILQRS GVGNAELLAE FDIPLVHDLP GVGENLQDHL 300
EMYLQYECKE PVSLYPALQW WNQPKIGAEW LFGGTGVGAS NHFEAGGFIR 350
SREEFAWPNI QYHFLPVAIN YNGSNAVKEH GFQCHVGSMR SPSRGHVRIK 400
SRDPHQHPAI LFNYMSHEQD WQEFRDAIRI TREIMHQPAL DQYRGREISP 450
GTECQTDEQL DEFVRNHAET AFHPCGTCKM GYDEMSVVDG EGRVHGLEGL 500
RVVDASIMPQ IITGNLNATT IMIGEKMADM IRGKEALPRS TAGYFVANGM 550
PVRAKKMSRD LN 562
Length:562
Mass (Da):62,633
Last modified:March 1, 2002 - v1
Checksum:i7DC9B36EC06D24ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG54653.1.
BA000007 Genomic DNA. Translation: BAB33780.1.
PIRiA85524.
E90673.
RefSeqiNP_286045.1. NC_002655.2.
NP_308384.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG54653; AAG54653; Z0398.
BAB33780; BAB33780; BAB33780.
GeneIDi914458.
957211.
KEGGiece:Z0398.
ecs:ECs0357.
PATRICi18349652. VBIEscCol44059_0348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG54653.1 .
BA000007 Genomic DNA. Translation: BAB33780.1 .
PIRi A85524.
E90673.
RefSeqi NP_286045.1. NC_002655.2.
NP_308384.1. NC_002695.1.

3D structure databases

ProteinModelPortali Q8X6C6.
SMRi Q8X6C6. Positions 1-531.
ModBasei Search...

Protein-protein interaction databases

STRINGi 155864.Z0398.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG54653 ; AAG54653 ; Z0398 .
BAB33780 ; BAB33780 ; BAB33780 .
GeneIDi 914458.
957211.
KEGGi ece:Z0398.
ecs:ECs0357.
PATRICi 18349652. VBIEscCol44059_0348.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci ECOL386585:GJFA-354-MONOMER.
ECOO157:BETA-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiBETA_ECO57
AccessioniPrimary (citable) accession number: Q8X6C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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